| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu Y et al. | Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4. | 2001 | Biochem. Pharmacol. | pmid:11377399 |
| Aripov UA et al. | [Immunodepressive properties of the drug "Batriden" in experiments on parabionts]. | 1975 | Dokl. Akad. Nauk SSSR | pmid:1140070 |
| Jones LA and Smith FH | Effect of free and bound gossypol on the absorption of L-]14-C]lysine, L-[14-C]methionine, and L-[14-C]valine from the rat small intestine. | 1975 Jul-Aug | J. Agric. Food Chem. | pmid:1141508 |
| Blom JH et al. | Reproductive efficiency and maternal-offspring transfer of gossypol in rainbow trout (Oncorhynchus mykiss) fed diets containing cottonseed meal. | 2001 | J. Anim. Sci. | pmid:11424691 |
| Henry MH et al. | The performance of broiler chicks fed diets containing extruded cottonseed meal supplemented with lysine. | 2001 | Poult. Sci. | pmid:11441843 |
| Gamboa DA et al. | Use of expander cottonseed meal in broiler diets formulated on a digestible amino acid basis. | 2001 | Poult. Sci. | pmid:11441847 |
| Gamboa DA et al. | Tissue distribution of gossypol enantiomers in broilers fed various cottonseed meals. | 2001 | Poult. Sci. | pmid:11469655 |
| Poprawski TJ and Jones WJ | Host plant effects on activity of the mitosporic fungi Beauveria bassiana and Paecilomyces fumosoroseus against two populations of Bemisia whiteflies (Homoptera: Aleyrodidae). | 2001 | Mycopathologia | pmid:11502058 |
| Herman DL and Smith FH | Effect of free gossypol on tissue uptake of iron by everted segments of rat duodenum. | 1975 May-Jun | J. Agric. Food Chem. | pmid:1151001 |
| Van Poznak C et al. | Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. | 2001 | Breast Cancer Res. Treat. | pmid:11510695 |
| Barak D et al. | Structural investigation of protein kinase C inhibitors. | 1991 | J Mol Struct | pmid:11538178 |
| Final report on the safety assessment of Hydrogenated Cottonseed Oil, Cottonseed (Gossypium) Oil, Cottonseed Acid, Cottonseed Glyceride, and Hydrogenated Cottonseed Glyceride. | 2001 | Int. J. Toxicol. | pmid:11558638 | |
| Henry MH et al. | Pathology and histopathology of gossypol toxicity in broiler chicks. | 2001 Jul-Sep | Avian Dis. | pmid:11569732 |
| Chen Y et al. | [Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice]. | 1997 | Yao Xue Xue Bao | pmid:11596197 |
| Yang B et al. | [The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts]. | 1997 | Yao Xue Xue Bao | pmid:11596304 |
| Baumgrass R et al. | Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol. | 2001 | J. Biol. Chem. | pmid:11598106 |
| Havránek F | [Gossypol, a new contraceptive agent for men]. | 1979 | Cesk Gynekol | pmid:116775 |
| Mena H et al. | The effects of feeding varying amounts of gossypol from whole cottonseed and cottonseed meal in lactating dairy cows. | 2001 | J. Dairy Sci. | pmid:11699455 |
| Dando C et al. | The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum. | 2001 | Mol. Biochem. Parasitol. | pmid:11704270 |
| Damaty SM and Hudson BJ | Preparation of low-gossypol cottonseed flour. | 1975 | J. Sci. Food Agric. | pmid:1172995 |
| Clawson AJ et al. | Unextracted cottonseed in diets for monogastric animals. I. The effect of ferrous sulfate and calcium hydroxide in reducing gossypol toxicity. | 1975 | J. Anim. Sci. | pmid:1173579 |
| Bressani R et al. | [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. | 1975 | Arch Latinoam Nutr | pmid:1174302 |
| Coviella CE et al. | Plant allocation to defensive compounds: interactions between elevated CO(2) and nitrogen in transgenic cotton plants. | 2002 | J. Exp. Bot. | pmid:11807136 |
| Kolena J et al. | Gossypol inhibits follicle-stimulating hormone- and epidermal growth factor-stimulated expansion of oocyte-cumulus complexes from porcine preovulatory follicles. | 2001 | Physiol Res | pmid:11829325 |
| Przybylski P and Brzezinski B | Spectroscopic studies and PM3 semiempirical calculations of Schiff bases of gossypol with L-amino acid methyl esters. | 2002 | Biopolymers | pmid:11842415 |
| Wang MS et al. | Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol. | 2002 | Acta Pharmacol. Sin. | pmid:11860745 |
| Romualdo GS et al. | Postweaning exposure to gossypol results in epididymis-specific effects throughout puberty and adulthood in rats. | 2002 Mar-Apr | J. Androl. | pmid:11868815 |
| Damaty S and Hudson BJ | A secondary interaction between gossypol and cottonseed protein. | 1975 | Proc Nutr Soc | pmid:1187618 |
| Schneider IC et al. | Fermentation of cottonseed and other feedstuffs in cattle rumen fluid. | 2002 | J. Agric. Food Chem. | pmid:11929282 |
| Jolad SD et al. | Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae). | 1975 | J Pharm Sci | pmid:1195125 |
| Bai J and Shi Y | Inhibition of T-type Ca(2+) currents in mouse spermatogenic cells by gossypol, an antifertility compound. | 2002 | Eur. J. Pharmacol. | pmid:11959082 |
| Lee KJ and Dabrowski K | Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal. | 2002 | J. Agric. Food Chem. | pmid:11982441 |
| Liu S et al. | The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. | 2002 Jan-Feb | Anticancer Res. | pmid:12017312 |
| Coutinho EM | Gossypol: a contraceptive for men. | 2002 | Contraception | pmid:12020773 |
| Qiu J et al. | Different pathways of cell killing by gossypol enantiomers. | 2002 | Exp. Biol. Med. (Maywood) | pmid:12037129 |
| Cheng JS et al. | Gossypol, a component in cottonseed, induced increases in cytosolic Ca2+ levels in Chang liver cells. | 2002 | Toxicon | pmid:12076637 |
| Santos JE et al. | Type of cottonseed and level of gossypol in diets of lactating dairy cows: effects on lactation performance and plasma gossypol. | 2002 | J. Dairy Sci. | pmid:12146481 |
| Uchijima Y et al. | [Effects of gossypol on human specific lactate dehydrogenase-C4 (LDH-C4)]. | 1989 | Nihon Funin Gakkai Zasshi | pmid:12158558 |
| Jiang J et al. | Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. | 2002 May-Jun | Anticancer Res. | pmid:12168828 |
| Przybylski P et al. | Spectroscopic studies and PM5 semiempirical calculations of new Schiff bases of gossypol with polyoxaalkylamines. | 2002 | Biopolymers | pmid:12209461 |
| Jensen JT | Male contraception. | 2002 | Curr Womens Health Rep | pmid:12215306 |
| Rogers GM et al. | Feeding cotton products to cattle. | 2002 | Vet. Clin. North Am. Food Anim. Pract. | pmid:12235661 |
| Zhang ZS et al. | [Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes]. | 1984 | Shengzhi Yu Biyun | pmid:12267337 |
| [The clinical study of gossypol in 8,806 men]. | 1985 | Shengzhi Yu Biyun | pmid:12267797 | |
| Huang JX et al. | [Studies on the synthesis of gossypol derivatives and their antifertility action]. | 1986 | Shengzhi Yu Biyun | pmid:12267916 |
| Tan FQ | [Gossypol acetate users]. | 1986 | Shengzhi Yu Biyun | pmid:12267917 |
| Han S | New progress in research on contraceptive technology. | 1986 | China Popul Newsl | pmid:12268508 |
| Xian SC et al. | Antifertility treating with long term gossypol. | 1987 | Adv Contracept Deliv Syst | pmid:12268655 |
| Future prospects in male contraception. | 1987 | Netw Res Triangle Park N C | pmid:12269106 | |
| Galegov GA et al. | [The effect of Kagocel on herpes virus reproduction]. | 2002 Jul-Aug | Vopr. Virusol. | pmid:12271726 |