| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sakhibov AD et al. | [Mechanism of Na,K-ATPase inhibition with gossypol and megasin]. | 1986 May-Jun | Vopr. Med. Khim. | pmid:3014735 |
| Karpovich LG et al. | [Indices of lymphocyte functional activity in patients with recurrent cutaneous-genital herpes during treatment with a herpes vaccine]. | 1986 Mar-Apr | Vopr. Virusol. | pmid:3014750 |
| Ahluwalia B et al. | Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis. | 1986 Jul-Aug | J. Androl. | pmid:3745012 |
| Kalla NR et al. | Studies on the male antifertility agent gossypol acetic acid. VII. Effect of motility stimulated factors on the revival of human spermatozoal motility after gossypol treatment in vitro. | 1986 Jul-Aug | Andrologia | pmid:3019180 |
| Wang JM et al. | Electrolyte composition of rete testis fluid and cauda epididymal plasma and spermatozoa from rats following gossypol treatment. | 1986 Jan-Feb | Andrologia | pmid:3954086 |
| Goldstein M | The future of male birth control. | 1986 | Plan Parent Rev | pmid:12340896 |
| Wang R | [Sister chromatid exchanges in gossypol formic acid users after its discontinuation]. | 1986 | Shengzhi Yu Biyun | pmid:12341303 |
| Li XX et al. | [Spermicidal effects in vitro of gossypol acetic acid-povidone coprecipitate]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2954422 |
| Wu DF and Yu YW | Superoxide free radical formation stimulated by (+/-), (+), (-) gossypol in rat liver and kidney microsomes. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2827151 |
| Heywood R et al. | The toxicity of gossypol to the male rat. | 1986 | Toxicology | pmid:3750328 |
| Pearce S et al. | Site of gossypol inhibition of steroidogenesis in purified mouse Leydig cells. | 1986 | J. Steroid Biochem. | pmid:3025516 |
| Radloff RJ et al. | Antiviral activities of gossypol and its derivatives against herpes simplex virus type II. | 1986 | Pharmacol Res Commun | pmid:3025895 |
| Robinson JM et al. | Gossypol-induced damage to mitochondria of transformed Sertoli cells. | 1986 | Am. J. Pathol. | pmid:3026188 |
| Krassnigg F et al. | Investigations on the functional role of angiotensin converting enzyme (ACE) in human seminal plasma. | 1986 | Adv. Exp. Med. Biol. | pmid:3028067 |
| Morris ID | Gossypol: a male contraceptive with potential? | 1986 | IRCS J Med Sci | pmid:12280996 |
| Pearce S et al. | Inhibition by gossypol of cyclic AMP production in mouse Leydig cells. | 1986 | Contraception | pmid:3030630 |
| Ye YX et al. | [Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:3035869 |
| Zhong CQ | [The morphology and formation of micronuclei of blood lymphocytes in man after cessation of gossypol administration]. | 1986 | Shengzhi Yu Biyun | pmid:12314624 |
| Cheng CC | A common structural pattern among many biologically active compounds of natural and synthetic origin. | 1986 | Med. Hypotheses | pmid:3090407 |
| Vongsorasak L and Svasti J | Gossypol prevents activation of purified proenzyme of human seminal plasma acidic proteinase. | 1986 | Biochim. Biophys. Acta | pmid:3091079 |
| Sun TS | [Long-term follow-up studies on patients poisoned by cottonseed oil]. | 1986 | Zhonghua Yi Xue Za Zhi | pmid:3091216 |
| Waites GM | Male fertility regulation: recent advances. | 1986 | Bull. World Health Organ. | pmid:3091279 |
| Caulfield JJ and Bolander FF | Involvement of protein kinase C in mouse mammary gland development. | 1986 | J. Endocrinol. | pmid:3084697 |
| Nayak BN and Buttar HS | Induction of sister chromatid exchanges and chromosome damage by gossypol in bone marrow cells of mice. | 1986 | Teratog., Carcinog. Mutagen. | pmid:2874644 |
| Reyes J et al. | Membrane actions of male contraceptive gossypol tautomers. | 1986 | Biochim. Biophys. Acta | pmid:3778905 |
| Rosenberg LJ et al. | Inhibition of DNA polymerase alpha by gossypol. | 1986 | Biochim. Biophys. Acta | pmid:3697356 |
| Wong YK and Li JH | [Quantum pharmacological investigations of gossypol and some simple aromatic compounds]. | 1986 | Yao Xue Xue Bao | pmid:3728037 |
| Medrano FJ and Andreu JM | Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules. | 1986 | Eur. J. Biochem. | pmid:3732269 |
| Walia V et al. | Effect of gossypol on peripheral blood cells. | 1986 | Indian J. Med. Res. | pmid:3733198 |
| Sheriff DS et al. | Gossypol and lipid peroxidation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3740171 |
| Sein GM | The embryotoxic and immunodepressive effects of gossypol. | 1986 | Am. J. Chin. Med. | pmid:3799526 |
| Burgos C et al. | In vitro inhibition by gossypol of oxidoreductases from human tissues. | 1986 | Biochem. Pharmacol. | pmid:3754138 |
| Joseph AE et al. | Cytotoxicity of enantiomers of gossypol. | 1986 | Br. J. Cancer | pmid:3756086 |
| Wichmann K et al. | Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. | 1986 | Contraception | pmid:3757514 |
| Jiang DH et al. | [The comparison of some properties of gossypol recrystallized from different solvents]. | 1986 | Yao Xue Xue Bao | pmid:3811948 |
| Eisele GR | A perspective on gossypol ingestion in swine. | 1986 | Vet Hum Toxicol | pmid:3705437 |
| Wu DF et al. | Pharmacokinetics of (+/-)-, (+)-, and (-)-gossypol in humans and dogs. | 1986 | Clin. Pharmacol. Ther. | pmid:3709025 |
| Kanje M et al. | The effect of gossypol on fast axonal transport and microtubule assembly. | 1986 | Biochim. Biophys. Acta | pmid:2421770 |
| Sampath DS and Balaram P | Resolution of racemic gossypol and interaction of individual enantiomers with serum albumins and model peptides. | 1986 | Biochim. Biophys. Acta | pmid:3085727 |
| Morris ID et al. | Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers. | 1986 | J. Reprod. Fertil. | pmid:3735252 |
| Zhao Y et al. | Studies on frequencies of sister chromatid exchange in peripheral blood lymphocytes before and after gossypol treatment. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3422992 |
| Förstermann U et al. | Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3487639 |
| Schmidt JH and Wells R | Recovery of soluble proteins from glanded cotton tissues with amines. | 1986 | Anal. Biochem. | pmid:3706729 |
| Zhang JB et al. | Effect of gossypol on fertilization capacity and chromosome formation of human sperm in vitro. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432238 |
| Ye WS et al. | Cytological toxicity of gossypol on rat gametogenesis and spermatozoa. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432239 |
| Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |
| Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
| Chen Y et al. | The effect of gossypol on the frequency of DNA-strand breaks in human leukocytes in vitro. | 1986 | Mutat. Res. | pmid:3951461 |
| Rikihisa Y and Lin YC | Taenia taeniaeformis: inhibition of metacestode development in the rat by gossypol. | 1986 | Exp. Parasitol. | pmid:3956677 |
| Ye WS et al. | [Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without metabolic activation by S9 mix]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2944636 |