| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnsen O et al. | Gossypol; a potent inhibitor of human sperm acrosomal proteinase. | 1982 | Int. J. Androl. | pmid:6761275 |
| Qian SZ et al. | Gossypol related hypokalemia. Clinicopharmacologic studies. | 1980 | Chin. Med. J. | pmid:6772395 |
| Tang XC et al. | [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. | 1980 | Yao Xue Xue Bao | pmid:6779501 |
| Liu GZ | Clinical study of gossypol as a male contraceptive. | 1981 Jul-Sep | Reproduccion | pmid:6793420 |
| Wu YM et al. | Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. | 1981 | Contraception | pmid:6796329 |
| Tso WW and Lee CS | Gossypol: an effective acrosin blocker. | 1982 | Arch. Androl. | pmid:6803693 |
| Hei LS | [Electron-microscopic observations on bioptic testicular tissue of cancerous patients after oral administration of gossypol (author's transl)]. | 1981 | Zhonghua Yi Xue Za Zhi | pmid:6804060 |
| Male fertility and its regulation: expanded abstracts. International symposium, Maui, Hawaii, October 9-15, 1982. | 1982 | Arch. Androl. | pmid:6812518 | |
| Hoshiai H et al. | Gossypol as oral contraceptive for male: trial case report. | 1982 | Tohoku J. Exp. Med. | pmid:6818716 |
| Eliasson R and Virji N | Effects of gossypol acetic acid on the activity of LDH-C4 from human and rabbit spermatozoa. | 1983 | Int. J. Androl. | pmid:6840877 |
| Tsui YC et al. | The effect of the male contraceptive agent Gossypol on human lymphocytes in vitro: traditional chromosome breakage, micronuclei, sister chromatid exchange, and cell kinetics. | 1983 | J. Med. Genet. | pmid:6842561 |
| Wong PY et al. | Lack of an effect of gossypol on the epididymis of the rat. | 1983 | Contraception | pmid:6851567 |
| Floridi A et al. | The effect of the association of Gossypol and Lonidamine on the energy metabolism of Ehrlich ascites tumor cells. | 1983 | Exp. Mol. Pathol. | pmid:6852206 |
| Vander Jagt DL et al. | Regulation of the glutathione S-transferase activity of bilirubin transport protein (ligandin) from human liver. Enzymic memory involving protein-protein interactions. | 1983 | J. Biol. Chem. | pmid:6853539 |
| Hoffer AP | Effects of gossypol on the seminiferous epithelium in the rat: a light and electron microscope study. | 1983 | Biol. Reprod. | pmid:6860736 |
| Royer RE and Vander Jagt DL | Gossypol binds to a high-affinity binding site on human serum albumin. | 1983 | FEBS Lett. | pmid:6862017 |
| Aitken RJ et al. | An analysis of the direct effects of gossypol on human spermatozoa. | 1983 | Int. J. Androl. | pmid:6862672 |
| Rovan E et al. | Ultrastructural analysis of rat testes after gossypol acetic acid (GAA) treatment. | 1983 | Urol. Res. | pmid:6868221 |
| Weinbauer GF et al. | Toxicity of gossypol at antifertility dosages in male rats: statistical analysis of lethal rates and body weight responses. | 1983 May-Jun | Andrologia | pmid:6881556 |
| Posinovec J | [Gossypol - the newest agent for the prevention of male fertility]. | 1983 | Lijec Vjesn | pmid:6888153 |
| Tso WW and Lee CS | Gossypol uncoupling of respiratory chain and oxidative phosphorylation in ejaculated boar spermatozoa. | 1982 | Contraception | pmid:6889482 |
| Tso WW and Lee CS | Cottonseed oil as a vaginal contraceptive. | 1982 | Arch. Androl. | pmid:6895984 |
| Sotelo A et al. | Infertility in male rats induced by diets containing whole cottonseed flour. | 1982 | J. Nutr. | pmid:6897076 |
| Gossypol as an oral contraceptive for men. | 1980 | J Med Soc N J | pmid:6928215 | |
| Shandilya LN and Clarkson TB | Hypolipidemic effects of gossypol in cynomolgus monkeys (Macaca fascicularis). | 1982 | Lipids | pmid:6952061 |
| Allamiiarova SA and Abidov MM | [Effect of the immunosuppressive agent batridene on contact allergic dermatitis induced by 2,4-dinitrochlorobenzene]. | 1982 | Vestn Dermatol Venerol | pmid:6979837 |
| Majumdar SK et al. | Mutagenic evaluation of two male contraceptives: 5-thio-d-glucose and gossypol acetic acid. | 1982 Jan-Feb | J. Hered. | pmid:7040540 |
| Jacobs HS | Contraception in the future. | 1981 | Proc Annu Symp Eugen Soc | pmid:7050975 |
| Cameron SM et al. | Vaginal spermicidal activity of gossypol in the Macaca arctoides. | 1982 | Fertil. Steril. | pmid:7060775 |
| Oko R and Hrudka F | Segmental aplasia of the mitochondrial sheath and sequelae induced by gossypol in rat spermatozoa. | 1982 | Biol. Reprod. | pmid:7066454 |
| Saksena SK and Salmonsen RA | Antifertility effects of gossypol in male hamsters. | 1982 | Fertil. Steril. | pmid:7075801 |
| Lei HP | [Review and prospect of gossypol research (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7090820 |
| Jiang DH and Xue H | [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7102321 |
| Tso WW and Lee CS | Lactate dehydrogenase-X: an isozyme particularly sensitive to gossypol inhibition. | 1982 | Int. J. Androl. | pmid:7107034 |
| Weinbauer GF et al. | Antifertility efficacy of gossypol acetic acid in male rats. | 1982 May-Jun | Andrologia | pmid:7114507 |
| Hoffer AP | Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol. | 1982 | Arch. Androl. | pmid:7114955 |
| Shandilya L et al. | Effects of gossypol on reproductive and endocrine functions of male cynomolgus monkeys (Macaca fascicularis). | 1982 | Biol. Reprod. | pmid:7115850 |
| Tso WW and Lee CS | Potassium leakage: not the cause of gossypol induced anti-motility in spermatozoa. | 1982 | Int. J. Androl. | pmid:7118270 |
| Jensen DR et al. | Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats. | 1982 | Toxicology | pmid:7135404 |
| Zhou LF et al. | [Further observations on the effect of prolonged administration of gossypol acetic acid to rats]. | 1982 | Yao Xue Xue Bao | pmid:7136708 |
| Lee CY et al. | Enzyme inactivation and inhibition by gossypol. | 1982 | Mol. Cell. Biochem. | pmid:7144742 |
| Moshchik KV et al. | [Treatment of genital herpes with levamisole in combination with megasine]. | 1982 Sep-Oct | Vopr. Virusol. | pmid:7147912 |
| Tang F et al. | Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins. | 1982 | Contraception | pmid:7160182 |
| Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. V. Effect of gossypol acetic acid on the fertility of male rats. | 1982 Nov-Dec | Andrologia | pmid:7165122 |
| Giridharan N et al. | Inhibition of rat testis LDH-X activity by gossypol. | 1982 | Contraception | pmid:7168954 |
| Majumdar SK et al. | Gossypol--an effective male contraceptive was not mutagenic in sperm head abnormality assay in mice. | 1982 | Can. J. Genet. Cytol. | pmid:7182060 |
| Lindsey TO et al. | Physiological responses of lactating cows to gossypol from cottonseed meal rations. | 1980 | J. Dairy Sci. | pmid:7189761 |
| Maugh TH | Male "pill" blocks sperm enzyme. | 1981 | Science | pmid:7193910 |
| Lin T et al. | Gossypol inhibits testicular steroidogenesis. | 1981 | Fertil. Steril. | pmid:7194804 |
| Ye YX et al. | [The effect of gossypol on the incorporation of H3-thymidine in the liver, testis and small intestine of experimental animals (author's transl)]. | 1981 | Yao Xue Xue Bao | pmid:7246187 |