Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Abou-Donia MB and Dieckert JW Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. 1974 Life Sci. pmid:4277086
Pirogov AI et al. [Postoperative bronchopleural complications in the combined treatment of lung cancer]. 1974 Vopr Onkol pmid:4211564
Abou-Donia MB and Dieckert JW Urinary and biliary excretion of 14C-gossypol in swine. 1974 J. Nutr. pmid:4830281
Skutches CL et al. Effect of dietary free gossypol on blood components and tissue iron in swine and rats. 1974 J. Nutr. pmid:4816926
Kilburn KH et al. Two patterns for bronchial damage from inhaled materials. 1974 Chest pmid:4819236
Skutches CL and Smith FH Effect of phenobarbital on the level of gossypol in the liver and the effect of gossypol and phenobarbital on liver microsomal O-demethylation and lipid peroxidation activities in the rat. 1974 J. Nutr. pmid:4430931
Abou-Donia MB et al. Gossypol: antagonistic effect on toxicity of insecticides to Spodoptera littoralis. 1974 Experientia pmid:4435119
Skutches CL and Smith FH Metabolism of gossypol, biosynthesized from methyl-14C-and carboxyl-14 C-labeled sodium acetate, in rat. 1974 J Am Oil Chem Soc pmid:4479245
el-Nockrashy AS et al. Biochemical changes in cottonseed during germination. 1974 Nahrung pmid:4365683
Mayorga H et al. [Extraction and precipitation of cottonseed protein by the wet method]. 1973 Arch Latinoam Nutr pmid:4801265
Lee J The inheritance of gossypol level in Gossypium. II. Inheritance of seed gosypol in two trains of cultivated Gossypoium barbadense L. 1973 Genetics pmid:4769299
Ogot JO The performance of pigs in Kenya fed cottonseed meal in mixtures of concentrate supplements. 1973 Bull Epizoot Dis Afr pmid:4808120
Finlay TH et al. Mechanism of the gossypol inactivation of pepsinogen. 1973 J. Biol. Chem. pmid:4718749
Skutches CL et al. Effect of intravenous gossypol injection on iron ultilization in swine. 1973 J. Nutr. pmid:4705271
Herman DL and Smith FH Effect of bound gossypol on the absorption of iron by rats. 1973 J. Nutr. pmid:4705274
Smith FH Effect of gossypol bound to cottonseed protein on growth of weanling rats. 1972 Jul-Aug J. Agric. Food Chem. pmid:5068584
Fishbein L Natural non-nutrient substances in the food chain. 1972 Sci. Total Environ. pmid:4121147
Albrecht JE et al. Rate of depletion and route of elimination of intravenously injected gossypol in swine. 1972 J. Anim. Sci. pmid:5085300
Kornegay ET et al. Fungal-treated cottonseed meal for swine. 1972 J. Nutr. pmid:4678034
Wong RC et al. Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin. 1972 J. Biol. Chem. pmid:4551945
Fedeli E and Jacini G Lipid composition of vegetable oils. 1971 Adv. Lipid Res. pmid:4942102
Berg LR and Lawrence WW Cottonseed meal, dehydrated grass and ascorbic acid as dietary factors preventing toxicity of vanadium for the chick. 1971 Poult. Sci. pmid:5109894
Albrecht JE et al. Effect of initial weight and days on feed on the accumulation of gossypol in pig livers. 1971 J. Anim. Sci. pmid:5546881
Abou-Donia MB and Dieckert JW Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases. 1971 Toxicol. Appl. Pharmacol. pmid:4998823
Husby FM and Kroening GH Energy value of cottonseed meal for swine. 1971 J. Anim. Sci. pmid:5171308
Dunbar CE and Herman RL Visceral granuloma in brook trout (Salvelinus fontinalis). 1971 J. Nutr. pmid:5171403
Braham JE et al. [Gossypol absorption in rats and in pigs]. 1971 Arch Latinoam Nutr pmid:5172839
Rolz C et al. [Method of wet concentration of protein of cotton seed cake processed by screw press]. 1971 Arch Latinoam Nutr pmid:5172841
Meksongsee LA et al. The in vivo effect of gossypol on cytochrome oxidase, succinoxidase, and succinic dehydrogenase in animal tissues. 1970 Sep-Oct J. Agric. Food Chem. pmid:4319770
Heinstein PF et al. Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. 1970 J. Biol. Chem. pmid:4318479
Tanksley TD et al. Inhibition of pepsinogen activation by gossypol. 1970 J. Biol. Chem. pmid:4922043
Vichkanova SA et al. [Antiviral properties of gossypol in experimental influenza pneumonia]. 1970 Antibiotiki pmid:5501368
Fry KE Some factors affecting the Hill reaction activity in cotton chloroplasts. 1970 Plant Physiol. pmid:5427116
Tone JN and Jensen DR Effect of ingested gossypol on the growth performance of rats. 1970 Experientia pmid:5478639
Abou-Donia MB et al. Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats. 1970 Lipids pmid:5484207
Smith FH and Clawson AJ The effects of dietary gossypol on animals. 1970 J Am Oil Chem Soc pmid:5487114
Mauron J [Chemical behavior of proteins at the time of preparation of nutrients and their biological effects]. 1970 Int Z Vitaminforsch pmid:5451301
Buitrago JA et al. Effects of dietary iron on gossypol accumulation in and elimination from porcine liver. 1970 J. Anim. Sci. pmid:5520345
Goriunova LV and Vichkanova SA [Study of antiviral effect of gossypol on chick embryo model]. 1969 Sep-Oct Farmakol Toksikol pmid:5364687
Lyman CM et al. Metabolism of gossypol in the chick. 1969 J Am Oil Chem Soc pmid:5779540
Baugher WL and Campbell TC Gossypol detoxication by fungi. 1969 Science pmid:5786644
Wood AB et al. Conformation and hydrogen bonding of gossypol. 1969 Chem. Ind. pmid:5357782
Graham GG et al. Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour. 1969 Am. J. Clin. Nutr. pmid:5819114
Cottonseed meal and tumors. 1969 Nutr. Rev. pmid:4311090
Sinnhuber RO et al. Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Cocarcinogenes by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer. 1968 J. Natl. Cancer Inst. pmid:4178161
Albrecht JE et al. Effects of high gossypol cottonseed meal on the electrocardiogram of swine. 1968 J. Anim. Sci. pmid:5744268
Vichkanova SA and Goriunova LV [Study of virulicidal effect of gossypol in vitro]. 1968 Antibiotiki pmid:4974209
Smith FH Determination of gossypol in leaves and flower buds of Gossypium. 1967 J Am Oil Chem Soc pmid:6041387
Margalith P Inhibitory effect of gossypol on microorganisms. 1967 Appl Microbiol pmid:6049314
Braham JE et al. Effect of calcium and gossypol on the performance of swine and on certain enzymes and other blood constituents. 1967 J. Nutr. pmid:6018252