Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Smith FH Determination of gossypol in leaves and flower buds of Gossypium. 1967 J Am Oil Chem Soc pmid:6041387
Margalith P Inhibitory effect of gossypol on microorganisms. 1967 Appl Microbiol pmid:6049314
Braham JE et al. Effect of calcium and gossypol on the performance of swine and on certain enzymes and other blood constituents. 1967 J. Nutr. pmid:6018252
Sharma MP et al. Effects of levels of protein and gossypol, and length of feeding period on the accumulation of gossypol in tissues of swine. 1966 J. Nutr. pmid:5931188
Muzaffaruddin M and Saxena ER Physicochemical studies on the composition and stability of metal-gossypol complexes. I. Fe+++ gossypol complex. 1966 J Am Oil Chem Soc pmid:5939582
Clawson AJ and Smith FH Effect of dietary iron on gossypol toxicity and on residues of gossypil in porcine liver. 1966 J. Nutr. pmid:5950205
Myers BD and Throneberry GO Effect of gossypol on some oxidative respiratory enzymes. 1966 Plant Physiol. pmid:4287149
VERMEL EM and KRUGLYAK SA ANTITUMOR ACTIVITY OF GOSSYPOL IN EXPERIMENTS ON TRANSPLANTABLE TUMORS. 1965 Jan-Feb Fed Proc Transl Suppl pmid:14275562
SMITH FH DETERMINATION OF FREE AND BOUND GOSSYPOL IN SWINE TISSUES. 1965 J Am Oil Chem Soc pmid:14268479
DANKE RJ and TILLMAN AD EFFECT OF GOSSYPOL AND HEXAHOMOSERINE ON PERFORMANCE OF RATS FED PURIFIED DIETS WITH AND WITHOUT LYSINE. 1965 J. Anim. Sci. pmid:14296177
Smith FH and Clawson AJ Effect of diet on accumulation of gossypol in the organs of swine. 1965 J. Nutr. pmid:5892976
Danke RJ and Tillman AD Effect of free gossypol and supplemental dietary iron on blood constituents of rats. 1965 J. Nutr. pmid:5897732
CASADY RB et al. FURTHER STUDIES OF DEGOSSYPOLIZED COTTONSEED MEAL AS A SOURCE OF PLANT PROTEIN IN RABBIT FEEDS. 1965 J Am Oil Chem Soc pmid:14328364
Klaasen GH [Gossypol, properties and occurrence]. 1965 Pharm Weekbl pmid:5321432
BRESSANI R et al. ALL-VEGETABLE PROTEIN MIXTURES FOR HUMAN FEEDING. XV. STUDIES IN DOGS ON THE ABSORPTION OF GASSYPOL FROM COTTONSEED FLOUR-CONTAINING VEGETABLE PROTEIN MIXTURES. 1964 J. Nutr. pmid:14191421
VERMEL EM THE SEARCH FOR ANTITUMOUR SUBSTANCES OF PLANT ORIGIN. 1964 Acta Unio Int Contra Cancrum pmid:14151888
VERMEL EM and KRUGLIAK SA [ANTINEOPLASTIC ACTIVITY OF GOSSYPOL IN EXPERIMENTAL TRANSPLANTED TUMORS]. 1963 Vopr Onkol pmid:14148612
HEINSTEIN PF et al. Biosynthesis of C-14-labeled gossypol. 1962 J. Biol. Chem. pmid:13906099
REISER R and FU HC The mechanism of gossypol detoxification by ruminant animals. 1962 J. Nutr. pmid:14491326
ADAMS R et al. Gossypol, a pigment of cottonseed. 1960 Chem. Rev. pmid:13681414
CONKERTON EJ and FRAMPTON VL Reaction of gossypol with free epsilon-amino groups of lysine in proteins. 1959 Arch. Biochem. Biophys. pmid:13637974
LYMAN CM et al. Reactions of proteins with gossypol. 1959 Arch. Biochem. Biophys. pmid:14419129
SMITH HA The pathology of gossypol poisoning. 1957 Mar-Apr Am. J. Pathol. pmid:13402891
CASTILLON LE et al. Preparation of combination products of gossypol with glycine and dextrose and their toxicity toward mice. 1953 Arch. Biochem. Biophys. pmid:13058367
GALLUP WD et al. Comparative effect on vitamin A metabolism in sheep of urea, soybean oil meal and cottonseed meal as sources of protein. 1951 J. Anim. Sci. pmid:14814051
AMBROSE AM and ROBBINS DJ Studies on the chronic oral toxicity of cottonseed meal and cottonseed pigment glands. 1951 J. Nutr. pmid:14851050
HARMS WS and HOLLEY KT Hypoprothrombinemia induced by gossypol. 1951 Proc. Soc. Exp. Biol. Med. pmid:14854026
COTTONSEED meal. 1951 Nutr. Rev. pmid:14863810
EAGLE E and BIALEK HF Effect of single and repeated doses of gossypol on the rat. 1950 May-Jun Food Res pmid:15427706
MARX MH Note of depression of spontaneous running activity by the appetite depressant gossypol in rats. 1950 J Comp Physiol Psychol pmid:14784530
PARHAM AP et al. The influence of solvent extracted and hydraulic processed cottonseed meals upon performance and level of plasma carotene, vitamin A, and fat in the blood of wintering beef cows. 1950 J. Anim. Sci. pmid:14794574
CASTILLON LE and ALTSCHUL AM Preparation of water-soluble combination products of gossypol and their toxicity to aquarium fish. 1950 Proc. Soc. Exp. Biol. Med. pmid:15440911
RUEGAMER WR and POLING CE Rat feeding tests with milk obtained from cows fed toxic cottonseed meal. 1950 J. Anim. Sci. pmid:15415370
HOFFPAUIR CL and GUTHRIE JD The use of aminized and phosphorylated cotton fabrics as ion exchange materials in the preparation of oil seed proteins. 1949 J. Biol. Chem. pmid:18112104
Eagle E Chronic Toxicity of Gossypol. 1949 Science pmid:17742136
FOSTER JW and WOODRUFF HB Microbiological aspects of penicillin; cottonseed meal as a substitute for corn steep liquor in penicillin production. 1946 J. Bacteriol. pmid:21064711
GRAU CR Protein concentrates as amino acid sources for the chick; corn gluten meal, cottonseed meal and peanut meal. 1946 J. Nutr. pmid:20999576
VISWESWARA RAO K and VASUDEVA SARMA R Occurrence of gossypol. 1945 Curr. Sci. pmid:21007609
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