| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jensen EC et al. | Lipoxygenase inhibitors shift the yeast/mycelium dimorphism in Ceratocystis ulmi. | 1992 | Appl. Environ. Microbiol. | pmid:1514797 |
| Zhou M et al. | Metabolic engineering of gossypol in cotton. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23775273 |
| Ahmed AA et al. | Gossypol as anti-fertility agent in female rats. | 1988 | Arch Exp Veterinarmed | pmid:3219036 |
| Leal-Garza CH et al. | [Frequency of sister chromatid exchange in mice treated with gossypol]. | 1990 Jul-Sep | Arch Invest Med (Mex) | pmid:2131768 |
| Bressani R et al. | [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. | 1975 | Arch Latinoam Nutr | pmid:1174302 |
| Mayorga H et al. | [Extraction and precipitation of cottonseed protein by the wet method]. | 1973 | Arch Latinoam Nutr | pmid:4801265 |
| Braham JE et al. | [Gossypol absorption in rats and in pigs]. | 1971 | Arch Latinoam Nutr | pmid:5172839 |
| Rolz C et al. | [Method of wet concentration of protein of cotton seed cake processed by screw press]. | 1971 | Arch Latinoam Nutr | pmid:5172841 |
| Hoffer AP | Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol. | 1982 | Arch. Androl. | pmid:7114955 |
| Cui G et al. | Gossypol with methyltestosterone and ethinylestradiol male does not affect rat spermatogonial stem cell differentiation. | 2007 Mar-Apr | Arch. Androl. | pmid:17453689 |
| Tso WW and Lee CS | Effect of gossypol on boar spermatozoa in vitro. | 1981 | Arch. Androl. | pmid:7271366 |
| Liu YX | Control of spermatogenesis in primate and prospect of male contraception. | 2005 Mar-Apr | Arch. Androl. | pmid:15804862 |
| Engler SJ et al. | Absence of histopathology in somatic tissues of rats made infertile with gossypol. | 1984 | Arch. Androl. | pmid:6534283 |
| Bhargava SK | Semen characteristics of gossypol-treated langurs (Presbytis entellus entellus Dufresne). | 1984 | Arch. Androl. | pmid:6537746 |
| Herrera J et al. | Cottonseed flour effects on androgen testicular content and serum levels in rats. | 1983 | Arch. Androl. | pmid:6688944 |
| Herrera J et al. | Modifications in the testis steroidogenic pathways in rats fed with cottonseed flour. | 1984 | Arch. Androl. | pmid:6236762 |
| Tso WW and Lee CS | Cottonseed oil as a vaginal contraceptive. | 1982 | Arch. Androl. | pmid:6895984 |
| Tso WW et al. | Effect of gossypol on boar spermatozoal adenosine triphosphate metabolism. | 1982 | Arch. Androl. | pmid:6219642 |
| Placzek R et al. | Effect of ace-inhibitors, calmodulin antagonists, acetylcholine receptor blocking, and alpha receptor blocking agents on motility of human sperm. | 1988 | Arch. Androl. | pmid:2903725 |
| Male fertility and its regulation: expanded abstracts. International symposium, Maui, Hawaii, October 9-15, 1982. | 1982 | Arch. Androl. | pmid:6812518 | |
| Tso WW and Lee CS | Gossypol: an effective acrosin blocker. | 1982 | Arch. Androl. | pmid:6803693 |
| CONKERTON EJ and FRAMPTON VL | Reaction of gossypol with free epsilon-amino groups of lysine in proteins. | 1959 | Arch. Biochem. Biophys. | pmid:13637974 |
| LYMAN CM et al. | Reactions of proteins with gossypol. | 1959 | Arch. Biochem. Biophys. | pmid:14419129 |
| CASTILLON LE et al. | Preparation of combination products of gossypol with glycine and dextrose and their toxicity toward mice. | 1953 | Arch. Biochem. Biophys. | pmid:13058367 |
| Hou DX et al. | Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis. | 2004 | Arch. Biochem. Biophys. | pmid:15246875 |
| Olgiati KL et al. | Gossypol inhibition of adenylate cyclase. | 1984 | Arch. Biochem. Biophys. | pmid:6732240 |
| Singh SK and Rath SK | Histologic changes in the mouse testis after treatment with gossypol tetra-acetic acid. | 1990 | Arch. Histol. Cytol. | pmid:2268474 |
| González-Garza MT et al. | Further studies on the in vitro activity of gossypol as antiamebic agent. | 1992 | Arch. Med. Res. | pmid:1340324 |
| González-Garza MT et al. | Gossypol anti-amebic effect in vivo. | 1997 | Arch. Med. Res. | pmid:9033108 |
| Cruz-Vega DE et al. | Determination of the antiamebic effect of a metronidazole/gossypol blend. | 1997 | Arch. Med. Res. | pmid:9033109 |
| González-Garza MT et al. | Entamoeba histolytica: inhibition of malic enzyme and alcohol dehydrogenase by (+/- )-, (+)-, and (-)- gossypol. | 1993 | Arch. Med. Res. | pmid:8274846 |
| Zhan Y et al. | Design and synthesis of a gossypol derivative with improved antitumor activities. | 2009 | Arch. Pharm. (Weinheim) | pmid:19340835 |
| Hamasaki Y et al. | [Rat basophilic leukemia-1 cell possesses 12-lipoxygenase and 5-lipoxygenase activities which are specifically inhibited by gossypol acetic acid]. | 1984 | Arerugi | pmid:6442854 |
| Aneja R et al. | Effect of gossypol in association with chromium protoporphyrin on heme metabolic enzymes. | 2004 | Artif Cells Blood Substit Immobil Biotechnol | pmid:15027808 |
| Badawy SZ et al. | Gossypol inhibits proliferation of endometrioma cells in culture. | 2007 | Asian J. Androl. | pmid:17486280 |
| Gu ZP et al. | Low dose gossypol for male contraception. | 2000 | Asian J. Androl. | pmid:11202417 |
| Zhang XQ et al. | Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. | 2010 | Asian J. Androl. | pmid:20657602 |
| D'Cruz SC et al. | Effects of plants and plant products on the testis. | 2010 | Asian J. Androl. | pmid:20562897 |
| Zhang XQ et al. | Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol. | 2010 | Asian J. Androl. | pmid:20081872 |
| Waites GM | The contribution of Asian scientists to global research in andrology. | 1999 | Asian J. Androl. | pmid:11225908 |
| Zhan YH et al. | Growth inhibition and apoptosis induction of human umbilical vein endothelial cells by apogossypolone. | 2013 | Asian Pac. J. Cancer Prev. | pmid:23679275 |
| Zelski RZ et al. | Gossypol toxicity in preruminant calves. | 1995 | Aust. Vet. J. | pmid:8599575 |
| Cusack PM and Perry V | The effect of feeding whole cottonseed on the fertility of bulls. | 1995 | Aust. Vet. J. | pmid:8825312 |
| Lian J et al. | The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. | 2010 | Autophagy | pmid:20930561 |
| Henry MH et al. | Pathology and histopathology of gossypol toxicity in broiler chicks. | 2001 Jul-Sep | Avian Dis. | pmid:11569732 |
| Wiest E et al. | Removal of endothelial function in coronary resistance vessels by saponin. | 1989 Sep-Oct | Basic Res. Cardiol. | pmid:2818447 |
| Pohl U and Lamontagne D | Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide. | 1991 | Basic Res. Cardiol. | pmid:1953621 |
| El-DIN S and Aboul-Ela S | Fish meal supplementation of chick starting rations containing cottonseed cake. | 1976 | Beitr Trop Landwirtsch Veterinarmed | pmid:990100 |
| Gunassekaran GR et al. | In vitro and in vivo studies on antitumor effects of gossypol on human stomach adenocarcinoma (AGS) cell line and MNNG induced experimental gastric cancer. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21782799 |
| de Peyster A et al. | Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6322752 |
| Olgiati KL and Toscano WA | Kinetics of gossypol inhibition of bovine lactate dehydrogenase X. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6615526 |
| Keniry MA et al. | The effect of gossypol and 6-aminonicotinamide on tumor cell metabolism: a 31P-magnetic resonance spectroscopic study. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2530981 |
| Srivastava AK and Padmanaban G | Gossypol mediated DNA degradation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619941 |
| Chang WY et al. | Gossypol induces spermidine/spermine N1-acetyltransferase in canine prostate epithelial cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070284 |
| Fornés MW et al. | Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8216260 |
| Pelosin JM et al. | Differential inhibition of protein kinase C subtypes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2363714 |
| Abe K et al. | Phosphorylation of coagulation factor II by phospholipid/Ca(2+)-dependent protein kinase (protein kinase C). | 1991 | Biochem. Biophys. Res. Commun. | pmid:2039497 |
| Priyadarshi A et al. | Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20206602 |
| McClarty GA et al. | Ribonucleotide reductase: an intracellular target for the male antifertility agent, gossypol. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3907637 |
| Whaley KJ et al. | A circular dichroism study of (+) gossypol binding to proteins. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743322 |
| Gu Y et al. | Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2162666 |
| Zaidi R and Hadi SM | Complexes involving gossypol, DNA and Cu(II). | 1992 | Biochem. Int. | pmid:1290468 |
| Tuhácková Z | Staurosporine and gossypol are inhibitors of the function of peptide elongation factor 1 alpha from rabbit reticulocytes. | 1994 | Biochem. Mol. Biol. Int. | pmid:8032322 |
| Gerez de Burgos NM et al. | Inhibition by gossypol of oxidoreductases from Trypanosoma cruzi. | 1984 | Biochem. Pharmacol. | pmid:6370265 |
| Yu Y et al. | Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4. | 2001 | Biochem. Pharmacol. | pmid:11377399 |
| Zhang M et al. | Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. | 2003 | Biochem. Pharmacol. | pmid:12818369 |
| Janero DR and Burghardt B | Protection of rat myocardial phospholipid against peroxidative injury through superoxide-(xanthine oxidase)-dependent, iron-promoted Fenton chemistry by the male contraceptive gossypol. | 1988 | Biochem. Pharmacol. | pmid:2840914 |
| Laughton MJ et al. | Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. | 1989 | Biochem. Pharmacol. | pmid:2476132 |
| Burgos C et al. | In vitro inhibition by gossypol of oxidoreductases from human tissues. | 1986 | Biochem. Pharmacol. | pmid:3754138 |
| Cooke E et al. | Diacylglycerol kinase inhibitor, R59022, potentiates neutrophil oxidase activation by Ca2+-dependent stimuli. Evidence for two separate but convergent pathways. | 1987 | Biochem. Pharmacol. | pmid:2823820 |
| Marzo I and Naval J | Bcl-2 family members as molecular targets in cancer therapy. | 2008 | Biochem. Pharmacol. | pmid:18638457 |
| Etxebarria A et al. | Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. | 2008 | Biochem. Pharmacol. | pmid:18762177 |
| de Peyster A et al. | Membrane structural/functional perturbations induced by gossypol. Effects on membrane order, liposome permeability, and insulin-sensitive hexose transport. | 1986 | Biochem. Pharmacol. | pmid:3533079 |
| Rajpurohit R and Giridharan N | Failure of oral gossypol to inhibit hepatic microsomal and cytosolic drug-metabolising enzymes. | 1988 | Biochem. Pharmacol. | pmid:3202895 |
| Lin TS et al. | Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. | 1993 | Biochem. Pharmacol. | pmid:8347147 |
| Bugeja V et al. | Primary mitochondrial activity of gossypol in yeast and mammalian cells. | 1988 | Biochem. Pharmacol. | pmid:2461202 |
| Javed MH and Waqar MA | Protective effect of histidine by inhibition of gossypol on rat's liver LDH-5. | 1995 | Biochem. Soc. Trans. | pmid:8654811 |
| Denisov AY et al. | Heat-induced dimerization of BCL-xL through alpha-helix swapping. | 2007 | Biochemistry | pmid:17223694 |
| Yu BZ et al. | Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates. | 1997 | Biochemistry | pmid:9376343 |
| Vongsorasak L and Svasti J | Gossypol prevents activation of purified proenzyme of human seminal plasma acidic proteinase. | 1986 | Biochim. Biophys. Acta | pmid:3091079 |
| Kimura K et al. | Inhibition by gossypol of phospholipid-sensitive Ca2+-dependent protein kinase from pig testis. | 1985 | Biochim. Biophys. Acta | pmid:3157405 |
| Reyes J et al. | Membrane actions of male contraceptive gossypol tautomers. | 1986 | Biochim. Biophys. Acta | pmid:3778905 |
| Rosenberg LJ et al. | Inhibition of DNA polymerase alpha by gossypol. | 1986 | Biochim. Biophys. Acta | pmid:3697356 |
| Jan CR et al. | Novel effects of gossypol, a chemical contraceptive in man: mobilization of internal Ca(2+) and activation of external Ca(2+) entry in intact cells. | 2000 | Biochim. Biophys. Acta | pmid:10771095 |
| Whaley KJ et al. | Optically active gossypol as a circular dichroism probe of interactions with serum albumins. | 1984 | Biochim. Biophys. Acta | pmid:6466708 |
| Kanje M et al. | The effect of gossypol on fast axonal transport and microtubule assembly. | 1986 | Biochim. Biophys. Acta | pmid:2421770 |
| Sampath DS and Balaram P | Resolution of racemic gossypol and interaction of individual enantiomers with serum albumins and model peptides. | 1986 | Biochim. Biophys. Acta | pmid:3085727 |
| Ohuchi K et al. | Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages. | 1988 | Biochim. Biophys. Acta | pmid:3136806 |
| Etindi RN and Rillema JA | Effect of kinase C inhibitor, gossypol, on the actions of prolactin in cultured mouse mammary tissues. | 1987 | Biochim. Biophys. Acta | pmid:2434140 |
| Antonietti P et al. | AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. | 2016 | Biochim. Biophys. Acta | pmid:26721623 |
| Hamasaki Y and Tai HH | Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases. | 1985 | Biochim. Biophys. Acta | pmid:3919771 |
| Vainio P et al. | Hydrolysis of phospholipid monolayers by human spermatozoa. Inhibition by male contraceptive gossypol. | 1985 | Biochim. Biophys. Acta | pmid:3978108 |
| Dabrowski K et al. | Gossypol isomers bind specifically to blood plasma proteins and spermatozoa of rainbow trout fed diets containing cottonseed meal. | 2001 | Biochim. Biophys. Acta | pmid:11342251 |
| Gawande ND et al. | Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking. | 2014 | Bioinformation | pmid:25512683 |
| Aver'ianov AA and Merzliak MN | [Chemiluminescence during oxidation of gossipol by peroxidase]. | 1978 | Biokhimiia | pmid:214169 |
| Tran PT et al. | Effect of gossypol on Spisula sperm observed with real-time confocal microscopy, polarized light microscopy, and video microscopy. | 1997 | Biol. Bull. | pmid:9390392 |
| Jinsart W et al. | Inhibition of wheat embryo calcium-dependent protein kinase and avian myosin light chain kinase by flavonoids and related compounds. | 1991 | Biol. Chem. Hoppe-Seyler | pmid:1772594 |
| Abe F et al. | Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. | 2004 | Biol. Pharm. Bull. | pmid:14709920 |
| Kennedy WP et al. | Gossypol inhibition of acrosin and proacrosin, and oocyte penetration by human spermatozoa. | 1983 | Biol. Reprod. | pmid:6416323 |
| Tanphaichitr N et al. | Direct effect of gossypol on TR-ST cells: perturbation of rhodamine 123 accumulation in mitochondria. | 1984 | Biol. Reprod. | pmid:6518226 |