Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Mushtaq M et al. Gossypol inhibits human chorionic gonadotropin-stimulated testosterone production by cultured canine testicular interstitial cells. 1996 Res. Commun. Mol. Pathol. Pharmacol. pmid:8829766
Chang WY et al. Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. 1996 Res. Commun. Mol. Pathol. Pharmacol. pmid:8827831
Graier WF et al. High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions. 1996 Diabetes pmid:8826976
Cusack PM and Perry V The effect of feeding whole cottonseed on the fertility of bulls. 1995 Aust. Vet. J. pmid:8825312
Barhoumi R and Burghardt RC Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. 1996 Fundam Appl Toxicol pmid:8812278
Wu Y et al. Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy. 1996 Biophys. J. pmid:8804592
Szücs G et al. Characterization of volume-activated chloride currents in endothelial cells from bovine pulmonary artery. 1996 J. Membr. Biol. pmid:8801351
Guan MZ and Wang NG [Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats]. 1996 Yao Xue Xue Bao pmid:8762457
Teng CS Gossypol-induced apoptotic DNA fragmentation correlates with inhibited protein kinase C activity in spermatocytes. 1995 Contraception pmid:8749604
González-Garza MT et al. Orally administered gossypol has no effect on eight hamster erythrocytic enzymes. 1995 Contraception pmid:8749602
Gschwentner M et al. Blockade of swelling-induced chloride channels by phenol derivatives. 1996 Br. J. Pharmacol. pmid:8733574
Liang XS et al. Developing gossypol derivatives with enhanced antitumor activity. 1995 Invest New Drugs pmid:8729944
Fan LP et al. [Emergency treatment and care of hypokalemia paralysis due to gossypol poisoning]. 1995 Zhonghua Hu Li Za Zhi pmid:8716068
Ohmura H [Suppressive effect of Gossypol, Gossypolone and serum from Gossypol treated rats on steroidogenesis in cultured porcine granulosa cells]. 1996 Nippon Ika Daigaku Zasshi pmid:8707919
Javed MH and Waqar MA Protective effect of histidine by inhibition of gossypol on rat's liver LDH-5. 1995 Biochem. Soc. Trans. pmid:8654811
Kim HL et al. Accumulation of gossypol enantiomers in ovine tissues. 1996 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:8653593
Nwoha PU and Aire TA Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. 1995 Contraception pmid:8605786
Nwoha PU and Aire TA The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. 1995 Contraception pmid:8605785
Nwoha PU The blood constituents of gossypol-treated, protein-malnourished Wistar rats. 1995 Contraception pmid:8605784
Zelski RZ et al. Gossypol toxicity in preruminant calves. 1995 Aust. Vet. J. pmid:8599575