Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Lee J The inheritance of gossypol level in Gossypium. II. Inheritance of seed gosypol in two trains of cultivated Gossypoium barbadense L. 1973 Genetics pmid:4769299
Ogot JO The performance of pigs in Kenya fed cottonseed meal in mixtures of concentrate supplements. 1973 Bull Epizoot Dis Afr pmid:4808120
Abou-Donia MB and Dieckert JW Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. 1974 Life Sci. pmid:4277086
Pirogov AI et al. [Postoperative bronchopleural complications in the combined treatment of lung cancer]. 1974 Vopr Onkol pmid:4211564
Abou-Donia MB and Dieckert JW Urinary and biliary excretion of 14C-gossypol in swine. 1974 J. Nutr. pmid:4830281
Skutches CL et al. Effect of dietary free gossypol on blood components and tissue iron in swine and rats. 1974 J. Nutr. pmid:4816926
Kilburn KH et al. Two patterns for bronchial damage from inhaled materials. 1974 Chest pmid:4819236
Smith FH Preparation of 14C-gossypol by incorporation of acetate-1-14C and acetate-2-14C by biosynthesis. 1974 J Am Oil Chem Soc pmid:4415176
Skutches CL and Smith FH Effect of phenobarbital on the level of gossypol in the liver and the effect of gossypol and phenobarbital on liver microsomal O-demethylation and lipid peroxidation activities in the rat. 1974 J. Nutr. pmid:4430931
Abou-Donia MB et al. Gossypol: antagonistic effect on toxicity of insecticides to Spodoptera littoralis. 1974 Experientia pmid:4435119
Skutches CL and Smith FH Metabolism of gossypol, biosynthesized from methyl-14C-and carboxyl-14 C-labeled sodium acetate, in rat. 1974 J Am Oil Chem Soc pmid:4479245
el-Nockrashy AS et al. Biochemical changes in cottonseed during germination. 1974 Nahrung pmid:4365683
Tone JN and Jensen DR Hematological effects of injected gossypol and iron in rats. 1974 Jan-Feb J. Agric. Food Chem. pmid:4811630
Damaty SM and Hudson BJ Preparation of low-gossypol cottonseed flour. 1975 J. Sci. Food Agric. pmid:1172995
Clawson AJ et al. Unextracted cottonseed in diets for monogastric animals. I. The effect of ferrous sulfate and calcium hydroxide in reducing gossypol toxicity. 1975 J. Anim. Sci. pmid:1173579
Bressani R et al. [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. 1975 Arch Latinoam Nutr pmid:1174302
Braham JE and Bressani R Effect of different levels of gossypol on transaminase activity, on nonessential to essential amino acid ratio, and on iron and nitrogen retention in rats. 1975 J. Nutr. pmid:1117346
Damaty S and Hudson BJ A secondary interaction between gossypol and cottonseed protein. 1975 Proc Nutr Soc pmid:1187618
Jolad SD et al. Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae). 1975 J Pharm Sci pmid:1195125
Abou-Donia MB and Dieckert JW Metabolic fate of gossypol: the metabolism of [14-C]gossypol in swine. 1975 Toxicol. Appl. Pharmacol. pmid:1129787
Dorsett PH et al. Letter: Antiviral activity of gossypol and apogossypol. 1975 J Pharm Sci pmid:1133739
Aripov UA et al. [Immunodepressive properties of the drug "Batriden" in experiments on parabionts]. 1975 Dokl. Akad. Nauk SSSR pmid:1140070
Pandey SN and Thejappa N Study on relationship between oil, protein, and gossypol in cottonseed kernels. 1975 J Am Oil Chem Soc pmid:1242138
Krylov VF [Treatment of patients with influenza]. 1975 Ter. Arkh. pmid:52894
Jones LA and Smith FH Effect of free and bound gossypol on the absorption of L-]14-C]lysine, L-[14-C]methionine, and L-[14-C]valine from the rat small intestine. 1975 Jul-Aug J. Agric. Food Chem. pmid:1141508
Herman DL and Smith FH Effect of free gossypol on tissue uptake of iron by everted segments of rat duodenum. 1975 May-Jun J. Agric. Food Chem. pmid:1151001
El-Nockrashy AS et al. Biochemical changes in cottonseed during development and maturity. 1976 Nahrung pmid:989153
El-DIN S and Aboul-Ela S Fish meal supplementation of chick starting rations containing cottonseed cake. 1976 Beitr Trop Landwirtsch Veterinarmed pmid:990100
Kulagin VI and Butov IuS [Treatment of plantal warts in children]. 1976 Vestn Dermatol Venerol pmid:997868
Roberts R Protein products and hulls for animal foods. 1976 J Am Oil Chem Soc pmid:932385
Skripkin IuK et al. [Treatment of viral skin diseases with Soviet-made antiviral drugs]. 1976 Vestn Dermatol Venerol pmid:1023645
Tone JN and Jensen DR The accumulation pattern of ingested gossypol in selected organs of the rat. 1976 Experientia pmid:1253913
Abou-Donia MB Physiological effects and metabolism of gossypol. 1976 Residue Rev pmid:778955
El-Nockrashy AS et al. Cottonseed colour fixed pigments. Part I. Selectivity of hexane isomers. 1976 Nahrung pmid:989152
Couch JR and Thomas MC A comparison of chemical methods for the determination of available lysine in various proteins. 1976 Sep-Oct J. Agric. Food Chem. pmid:989491
Jones LA and Smith FH Effect of bound gossypol and amino acid supplementation of glandless cottonseed meal on the growth of weanling rats. 1977 J. Anim. Sci. pmid:576596
Jones LA and Smith FH Effect of gossypol on the removal of nitrogen and amino acids from feed in digestion by the rat. 1977 J. Anim. Sci. pmid:576597
Cornu A et al. [Utilization of gossypol-free cottonseed and its by-products as human food]. 1977 Ann Nutr Aliment pmid:579293
Broderick GA Effect of processing on protein utilization by ruminants. 1977 Adv. Exp. Med. Biol. pmid:906927
Khadzhibaev GS et al. [Interferonogenic activity of gossypol, a low-molecular substance]. 1978 Antibiotiki pmid:206198
Aver'ianov AA and Merzliak MN [Chemiluminescence during oxidation of gossipol by peroxidase]. 1978 Biokhimiia pmid:214169
Alford BB and Onley K The minimum cottonseed protein required for nitrogen balance in women. 1978 J. Nutr. pmid:580097
Cherry JP et al. Potential for improving cottonseed quality by genetic and agronomic practices. 1978 Adv. Exp. Med. Biol. pmid:581532
Gossypol--a new antifertility agent for males. 1978 Chin. Med. J. pmid:104833
de Buckle TS et al. Two food applications of cottonseed flours and meals. 1979 J Am Oil Chem Soc pmid:583421
Wang YE et al. [Studies o the anti-fertility actions of cotton seed meal and gossypol (author's transl)]. 1979 Yao Xue Xue Bao pmid:583588
Chen ZC et al. [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. 1979 Yao Xue Xue Bao pmid:532653
Nadakavukaren MJ et al. Effect of gossypol on the ultrastructure of rat spermatozoa. 1979 Cell Tissue Res. pmid:535032
de Peyster A and Wang YY Gossypol--proposed contraceptive for men passes the Ames test. 1979 N. Engl. J. Med. pmid:450009
Havránek F [Gossypol, a new contraceptive agent for men]. 1979 Cesk Gynekol pmid:116775