| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Carrière Y et al. | Effects of gossypol on fitness costs associated with resistance to Bt cotton in pink bollworm. | 2004 | J. Econ. Entomol. | pmid:15568363 |
| Oliver CL et al. | In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. | 2004 | Clin. Cancer Res. | pmid:15570010 |
| Wang X et al. | Development of monoclonal antibody-based enzyme-linked immunosorbent assay for gossypol analysis in cottonseed meals. | 2004 | J. Agric. Food Chem. | pmid:15612757 |
| Mandal AB et al. | Comparison of broiler chicken performance when fed diets containing meals of Bollgard II hybrid cotton containing Cry-X gene (Cry1Ac and Cry2ab gene), parental line or commercial cotton. | 2004 | Br. Poult. Sci. | pmid:15623220 |
| Chang JS et al. | Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15554914 |
| Przybylski P et al. | Schiff base of gossypol with 3,6,9-trioxa-decylamine complexes with monovalent cations studied by mass spectrometry, (1)H-NMR, FTIR, and PM5 semiempirical methods. | 2004 | Biopolymers | pmid:14991665 |
| Hassan ME et al. | Reversibility of the reproductive toxicity of gossypol in peripubertal bulls. | 2004 | Theriogenology | pmid:15037004 |
| Ergun MA et al. | Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells. | 2004 | Cell Biol. Int. | pmid:14984751 |
| Aneja R et al. | Effect of gossypol in association with chromium protoporphyrin on heme metabolic enzymes. | 2004 | Artif Cells Blood Substit Immobil Biotechnol | pmid:15027808 |
| Bork S et al. | Identification of Babesia bovis L-lactate dehydrogenase as a potential chemotherapeutical target against bovine babesiosis. | 2004 | Mol. Biochem. Parasitol. | pmid:15478796 |
| Susman E | Cottonseed-oil byproduct as anticancer radiation sensitiser. | 2004 | Lancet Oncol. | pmid:15536689 |
| Hamilton KA et al. | Bollgard II cotton: compositional analysis and feeding studies of cottonseed from insect-protected cotton (Gossypium hirsutum L.) producing the Cry1Ac and Cry2Ab2 proteins. | 2004 | J. Agric. Food Chem. | pmid:15537305 |
| Han J et al. | [Determination of anti-nutrients in genetically modified crops]. | 2004 | Wei Sheng Yan Jiu | pmid:15727185 |
| Cui X et al. | [Determination of free gossypol in meat by reversed-phased high performance liquid chromatography]. | 2004 | Se Pu | pmid:15706952 |
| Yildirim-Aksoy M et al. | In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)- and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. | 2004 | J. Appl. Microbiol. | pmid:15186445 |
| Garcia-Abiado MA et al. | Effect of diets containing gossypol on blood parameters and spleen structure in tilapia, Oreochromis sp., reared in a recirculating system. | 2004 | J. Fish Dis. | pmid:15189376 |
| Du L et al. | Effect of cotton cultivar on development and reproduction of Aphis gossypii (Homoptera: Aphididae) and its predator Propylaea japonica (Coleoptera: Coccinellidae). | 2004 | J. Econ. Entomol. | pmid:15384338 |
| Tripathi AK et al. | An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme. | 2004 | Eur. J. Biochem. | pmid:15317584 |
| Cass QB et al. | Determination of gossypol enantiomer ratio in cotton plants by chiral higher-performance liquid chromatography. | 2004 | J. Agric. Food Chem. | pmid:15366827 |
| Meyer R et al. | Identification and quantification of gossypol in cotton by using packed micro-tips columns in combination with HPLC. | 2004 | Anal Bioanal Chem | pmid:15372136 |
| Yang ZJ et al. | Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. | 2004 | Contraception | pmid:15325889 |
| Mena H et al. | The effects of varying gossypol intake from whole cottonseed and cottonseed meal on lactation and blood parameters in lactating dairy cows. | 2004 | J. Dairy Sci. | pmid:15328274 |
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| Hou DX et al. | Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis. | 2004 | Arch. Biochem. Biophys. | pmid:15246875 |
| Przybylski P et al. | The schiff base of gossypol with 3,6,9,12,15,18,21,24-octaoxa-pentacosylamine complexes and monovalent cations studied by electrospray ionization-mass spectrometry, (1)H nuclear magnetic resonance, Fourier transform infrared, as well as PM5 semiempirical methods. | 2004 | Biopolymers | pmid:15211497 |
| Fombad RB and Bryant MJ | Effects of cottonseed cake-based diets supplemented with blood meal, alone or with lysine, on the growth of pigs. | 2004 | Trop Anim Health Prod | pmid:15241972 |
| Fombad RB and Bryant MJ | An evaluation of the use of cottonseed cake in the diet of growing pigs. | 2004 | Trop Anim Health Prod | pmid:15080544 |
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| Abe F et al. | Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. | 2004 | Biol. Pharm. Bull. | pmid:14709920 |
| Cui GH et al. | A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats. | 2004 | Contraception | pmid:15451339 |
| Xu YH et al. | Characterization of GaWRKY1, a cotton transcription factor that regulates the sesquiterpene synthase gene (+)-delta-cadinene synthase-A. | 2004 | Plant Physiol. | pmid:15133151 |
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| Aneja R et al. | Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male Wistar rats. | 2003 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:14527098 |
| Zhang M et al. | Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. | 2003 | Biochem. Pharmacol. | pmid:12818369 |
| Dowd MK | Preparation of enantiomeric gossypol by crystallization. | 2003 | Chirality | pmid:12774287 |
| Yurtcu E et al. | Apoptotic effect of gossypol on human lymphocytes. | 2003 | Cell Biol. Int. | pmid:12972286 |
| Wang YH et al. | 8-Hydroxy-(+)-delta-cadinene is a precursor to hemigossypol in Gossypium hirsutum. | 2003 | Phytochemistry | pmid:12946420 |
| Kitada S et al. | Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. | 2003 | J. Med. Chem. | pmid:13678404 |
| Santos JE et al. | Type of cottonseed and level of gossypol in diets of lactating dairy cows: plasma gossypol, health, and reproductive performance. | 2003 | J. Dairy Sci. | pmid:12703626 |
| Dao VT et al. | New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents. | 2003 | Bioorg. Med. Chem. | pmid:12670651 |
| Keller PA et al. | Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor. | 2003 | J. Mol. Graph. Model. | pmid:12543135 |
| Bai JP et al. | Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction. | 2003 | Eur. J. Pharmacol. | pmid:12600689 |
| Prieto JG et al. | Increasing dietary levels of cracked pima cottonseed increase plasma gossypol but do not influence productive performance of lactating Holstein cows. | 2003 | J. Dairy Sci. | pmid:12613869 |
| Shi YL et al. | Ion-channels in human sperm membrane and contraceptive mechanisms of male antifertility compounds derived from Chinese traditional medicine. | 2003 | Acta Pharmacol. Sin. | pmid:12511225 |
| Freedman TB et al. | Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism. | 2003 | Chirality | pmid:12520512 |
| Dowd MK and Stevens ED | The gossypol-cyclododecanone (1/2) inclusion complex. | 2003 | Acta Crystallogr C | pmid:12855869 |
| Jo C et al. | Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in methanol. | 2003 | Food Chem. Toxicol. | pmid:12909266 |
| Räsänen TL et al. | Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. | 2003 | Scand. J. Gastroenterol. | pmid:12889567 |
| Kawanishi K et al. | Aldose reductase inhibitors from the nature. | 2003 | Curr. Med. Chem. | pmid:12871134 |
| Kovacic P | Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. | 2003 | Curr. Med. Chem. | pmid:14529461 |
| Cheng JS et al. | Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells. | 2003 | Chin J Physiol | pmid:14672280 |
| NarovlianskiÄ AN et al. | [Effect of interferon inductors on infection induced by hepatitis C virus and activity of mRNA cytokines in cell cultures SW-13 and MT-4]. | 2002 Nov-Dec | Vopr. Virusol. | pmid:12508677 |
| Jiang J et al. | Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. | 2002 May-Jun | Anticancer Res. | pmid:12168828 |
| Romualdo GS et al. | Postweaning exposure to gossypol results in epididymis-specific effects throughout puberty and adulthood in rats. | 2002 Mar-Apr | J. Androl. | pmid:11868815 |
| Galegov GA et al. | [The effect of Kagocel on herpes virus reproduction]. | 2002 Jul-Aug | Vopr. Virusol. | pmid:12271726 |
| Liu S et al. | The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. | 2002 Jan-Feb | Anticancer Res. | pmid:12017312 |
| Qiu J et al. | Different pathways of cell killing by gossypol enantiomers. | 2002 | Exp. Biol. Med. (Maywood) | pmid:12037129 |
| Lee KJ and Dabrowski K | High-performance liquid chromatographic determination of gossypol and gossypolone enantiomers in fish tissues using simultaneous electrochemical and ultraviolet detectors. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12361745 |
| Velasquez-Pereira J et al. | Effects of gossypol from cottonseed meal and dietary vitamin E on the reproductive characteristics of superovulated beef heifers. | 2002 | J. Anim. Sci. | pmid:12350026 |
| Puckhaber LS et al. | Toxicity of (+)- and (-)-gossypol to the plant pathogen, Rhizoctonia solani. | 2002 | J. Agric. Food Chem. | pmid:12428953 |
| Przybylski P et al. | Spectroscopic studies and PM5 semiempirical calculations of new Schiff bases of gossypol with polyoxaalkylamines. | 2002 | Biopolymers | pmid:12209461 |
| Jensen JT | Male contraception. | 2002 | Curr Womens Health Rep | pmid:12215306 |
| Rogers GM et al. | Feeding cotton products to cattle. | 2002 | Vet. Clin. North Am. Food Anim. Pract. | pmid:12235661 |
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| Mego M | Telomerase inhibitors in anticancer therapy: gossypol as a potential telomerase inhibitor. | 2002 | Bratisl Lek Listy | pmid:12583508 |
| Kuhn G et al. | Gossypol induces chloride secretion in rat proximal colon. | 2002 | Eur. J. Pharmacol. | pmid:12464365 |
| Risco CA et al. | Effects of gossypol from cottonseed on hematological responses and plasma alpha-tocopherol concentration of dairy cows. | 2002 | J. Dairy Sci. | pmid:12512612 |
| Le Blanc M et al. | An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines. | 2002 | Pharmacol. Res. | pmid:12457630 |
| Vershinina MY et al. | Regulation of cytokine mRNAs by interferon and interferon inducers. | 2002 | Russ. J. Immunol. | pmid:12687259 |
| Lee KJ et al. | A mixture of cottonseed meal, soybean meal and animal byproduct mixture as a fish meal substitute: growth and tissue gossypol enantiomer in juvenile rainbow trout (Oncorhynchus mykiss). | 2002 | J Anim Physiol Anim Nutr (Berl) | pmid:15379906 |
| Phillis JW et al. | Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. | 2002 | Brain Res. | pmid:12443975 |
| Wang MS et al. | Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol. | 2002 | Acta Pharmacol. Sin. | pmid:11860745 |
| Schneider IC et al. | Fermentation of cottonseed and other feedstuffs in cattle rumen fluid. | 2002 | J. Agric. Food Chem. | pmid:11929282 |
| Przybylski P and Brzezinski B | Spectroscopic studies and PM3 semiempirical calculations of Schiff bases of gossypol with L-amino acid methyl esters. | 2002 | Biopolymers | pmid:11842415 |
| Coviella CE et al. | Plant allocation to defensive compounds: interactions between elevated CO(2) and nitrogen in transgenic cotton plants. | 2002 | J. Exp. Bot. | pmid:11807136 |
| Santos JE et al. | Type of cottonseed and level of gossypol in diets of lactating dairy cows: effects on lactation performance and plasma gossypol. | 2002 | J. Dairy Sci. | pmid:12146481 |
| Bai J and Shi Y | Inhibition of T-type Ca(2+) currents in mouse spermatogenic cells by gossypol, an antifertility compound. | 2002 | Eur. J. Pharmacol. | pmid:11959082 |
| Coutinho EM | Gossypol: a contraceptive for men. | 2002 | Contraception | pmid:12020773 |
| Lee KJ and Dabrowski K | Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal. | 2002 | J. Agric. Food Chem. | pmid:11982441 |
| Cheng JS et al. | Gossypol, a component in cottonseed, induced increases in cytosolic Ca2+ levels in Chang liver cells. | 2002 | Toxicon | pmid:12076637 |
| Henry MH et al. | Pathology and histopathology of gossypol toxicity in broiler chicks. | 2001 Jul-Sep | Avian Dis. | pmid:11569732 |
| Nogueda-Torres B et al. | Trypanocidal activity of 4 isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi. | 2001 Jan-Mar | Rev. Latinoam. Microbiol. | pmid:17061565 |
| Yu Y et al. | Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4. | 2001 | Biochem. Pharmacol. | pmid:11377399 |
| Baumgrass R et al. | Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol. | 2001 | J. Biol. Chem. | pmid:11598106 |
| Mena H et al. | The effects of feeding varying amounts of gossypol from whole cottonseed and cottonseed meal in lactating dairy cows. | 2001 | J. Dairy Sci. | pmid:11699455 |
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| Final report on the safety assessment of Hydrogenated Cottonseed Oil, Cottonseed (Gossypium) Oil, Cottonseed Acid, Cottonseed Glyceride, and Hydrogenated Cottonseed Glyceride. | 2001 | Int. J. Toxicol. | pmid:11558638 | |
| Van Poznak C et al. | Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. | 2001 | Breast Cancer Res. Treat. | pmid:11510695 |
| Gamboa DA et al. | Tissue distribution of gossypol enantiomers in broilers fed various cottonseed meals. | 2001 | Poult. Sci. | pmid:11469655 |
| Poprawski TJ and Jones WJ | Host plant effects on activity of the mitosporic fungi Beauveria bassiana and Paecilomyces fumosoroseus against two populations of Bemisia whiteflies (Homoptera: Aleyrodidae). | 2001 | Mycopathologia | pmid:11502058 |
| Kolena J et al. | Gossypol inhibits follicle-stimulating hormone- and epidermal growth factor-stimulated expansion of oocyte-cumulus complexes from porcine preovulatory follicles. | 2001 | Physiol Res | pmid:11829325 |
| Dabrowski K et al. | Gossypol isomers bind specifically to blood plasma proteins and spermatozoa of rainbow trout fed diets containing cottonseed meal. | 2001 | Biochim. Biophys. Acta | pmid:11342251 |
| Benson CG et al. | Improved method for the rapid determination of terpenoid aldehydes in cotton. | 2001 | J. Agric. Food Chem. | pmid:11368574 |
| Blom JH et al. | Reproductive efficiency and maternal-offspring transfer of gossypol in rainbow trout (Oncorhynchus mykiss) fed diets containing cottonseed meal. | 2001 | J. Anim. Sci. | pmid:11424691 |
| Henry MH et al. | The performance of broiler chicks fed diets containing extruded cottonseed meal supplemented with lysine. | 2001 | Poult. Sci. | pmid:11441843 |
| Gamboa DA et al. | Use of expander cottonseed meal in broiler diets formulated on a digestible amino acid basis. | 2001 | Poult. Sci. | pmid:11441847 |
| Jiang J et al. | The effects of gossypol on the invasiveness of MAT-LyLu cells and MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats. | 2000 Nov-Dec | Anticancer Res. | pmid:11205308 |
| Brandes AA et al. | New drugs in recurrent high grade gliomas. | 2000 May-Jun | Anticancer Res. | pmid:10928126 |