Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Bai J and Shi Y Inhibition of T-type Ca(2+) currents in mouse spermatogenic cells by gossypol, an antifertility compound. 2002 Eur. J. Pharmacol. pmid:11959082
Lee KJ and Dabrowski K Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal. 2002 J. Agric. Food Chem. pmid:11982441
Liu S et al. The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. 2002 Jan-Feb Anticancer Res. pmid:12017312
Coutinho EM Gossypol: a contraceptive for men. 2002 Contraception pmid:12020773
Qiu J et al. Different pathways of cell killing by gossypol enantiomers. 2002 Exp. Biol. Med. (Maywood) pmid:12037129
Cheng JS et al. Gossypol, a component in cottonseed, induced increases in cytosolic Ca2+ levels in Chang liver cells. 2002 Toxicon pmid:12076637
Santos JE et al. Type of cottonseed and level of gossypol in diets of lactating dairy cows: effects on lactation performance and plasma gossypol. 2002 J. Dairy Sci. pmid:12146481
Uchijima Y et al. [Effects of gossypol on human specific lactate dehydrogenase-C4 (LDH-C4)]. 1989 Nihon Funin Gakkai Zasshi pmid:12158558
Jiang J et al. Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. 2002 May-Jun Anticancer Res. pmid:12168828
Przybylski P et al. Spectroscopic studies and PM5 semiempirical calculations of new Schiff bases of gossypol with polyoxaalkylamines. 2002 Biopolymers pmid:12209461
Jensen JT Male contraception. 2002 Curr Womens Health Rep pmid:12215306
Rogers GM et al. Feeding cotton products to cattle. 2002 Vet. Clin. North Am. Food Anim. Pract. pmid:12235661
Zhang ZS et al. [Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes]. 1984 Shengzhi Yu Biyun pmid:12267337
[The clinical study of gossypol in 8,806 men]. 1985 Shengzhi Yu Biyun pmid:12267797
Huang JX et al. [Studies on the synthesis of gossypol derivatives and their antifertility action]. 1986 Shengzhi Yu Biyun pmid:12267916
Tan FQ [Gossypol acetate users]. 1986 Shengzhi Yu Biyun pmid:12267917
Han S New progress in research on contraceptive technology. 1986 China Popul Newsl pmid:12268508
Xian SC et al. Antifertility treating with long term gossypol. 1987 Adv Contracept Deliv Syst pmid:12268655
Future prospects in male contraception. 1987 Netw Res Triangle Park N C pmid:12269106
Galegov GA et al. [The effect of Kagocel on herpes virus reproduction]. 2002 Jul-Aug Vopr. Virusol. pmid:12271726