| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen ZC et al. | [The influence of gossypol on the potassium metabolism of rats and the effect of some possible contributing factors (low-K and low-MG intake) (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532653 |
| Nadakavukaren MJ et al. | Effect of gossypol on the ultrastructure of rat spermatozoa. | 1979 | Cell Tissue Res. | pmid:535032 |
| de Peyster A and Wang YY | Gossypol--proposed contraceptive for men passes the Ames test. | 1979 | N. Engl. J. Med. | pmid:450009 |
| Lindsey TO et al. | Physiological responses of lactating cows to gossypol from cottonseed meal rations. | 1980 | J. Dairy Sci. | pmid:7189761 |
| Chang MC et al. | Effects of Gossypol on the fertility of male rats, hamsters and rabbits. | 1980 | Contraception | pmid:7428357 |
| Shepu X et al. | Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. | 1980 | Sci. Sin. | pmid:7403840 |
| Muratov MM et al. | [Hygienic evaluation of acetate fabric dyed with technical grade gossypol]. | 1980 | Gig Sanit | pmid:7372107 |
| Abidov MM et al. | [Effect of the immunodepressive preparation, batriden, on the course of experimental allergic dermatitis]. | 1980 | Vestn Dermatol Venerol | pmid:7376717 |
| Coulson PB et al. | Short term metabolic effects of the anti-fertility agent, gossypol, on various reproductive organs of male mice. | 1980 | Int. J. Androl. | pmid:7440012 |
| Cheng KF et al. | Endometrial changes after administration of gossypol for menorrhagia. | 1980 | Am. J. Obstet. Gynecol. | pmid:7446637 |
| Waller DP et al. | In vitjro spermicidal activity of gossypol. | 1980 | Contraception | pmid:7449381 |
| Sang GW et al. | [Chronic toxicity of gossypol and the relationship to its metabolic fate in dogs and monkeys (author's transl)]. | 1980 | Zhongguo Yao Li Xue Bao | pmid:6461173 |
| Han HL | [Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)]. | 1980 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6451316 |
| Pösö H et al. | Gossypol, a powerful inhibitor of human spermatozoal metabolism. | 1980 | Lancet | pmid:6103251 |
| Gossypol as an oral contraceptive for men. | 1980 | J Med Soc N J | pmid:6928215 | |
| Qian SZ et al. | Gossypol related hypokalemia. Clinicopharmacologic studies. | 1980 | Chin. Med. J. | pmid:6772395 |
| Tang XC et al. | [Comparative studies on the absorption, distribution and excretion of 14C-gossypol in four species of animals (author's transl)]. | 1980 | Yao Xue Xue Bao | pmid:6779501 |
| Labzo SS et al. | [Stimulation of interferon formation by natural and synthetic inducers in cultures of human tonsil cells]. | 1980 Jan-Feb | Vopr. Virusol. | pmid:6158181 |
| Vagabov RM et al. | [Comparative study of the effectiveness of the interferon inducers, poly(I) : poly(C) and GSS (gossypol-beta-aminoethylsodium sulfate), in combination with a specific vaccine in experimental infection with the human acute encephalomyelitis virus]. | 1980 May-Jun | Vopr. Virusol. | pmid:7434726 |
| Wen W | China invents male birth control pill. | 1980 Spring-Summer | Am. J. Chin. Med. | pmid:7395797 |
| Maugh TH | Male "pill" blocks sperm enzyme. | 1981 | Science | pmid:7193910 |
| Lin T et al. | Gossypol inhibits testicular steroidogenesis. | 1981 | Fertil. Steril. | pmid:7194804 |
| Jacobs HS | Contraception in the future. | 1981 | Proc Annu Symp Eugen Soc | pmid:7050975 |
| Ye YX et al. | [The effect of gossypol on the incorporation of H3-thymidine in the liver, testis and small intestine of experimental animals (author's transl)]. | 1981 | Yao Xue Xue Bao | pmid:7246187 |
| Tso WW and Lee CS | Effect of gossypol on boar spermatozoa in vitro. | 1981 | Arch. Androl. | pmid:7271366 |
| Bozek SA et al. | Scanning electron microscopic study of spermatozoa from gossypol-treated rats. | 1981 | Cell Tissue Res. | pmid:7273120 |
| Hahn DW et al. | Antifertility and endocrine activities of gossypol in rodents. | 1981 | Contraception | pmid:7273769 |
| Waller DP et al. | Antifertility effects of gossypol and its impurities on male hamsters. | 1981 | Contraception | pmid:7285581 |
| Sakesena SK et al. | Gossypol: its toxicological and endocrinological effects in male rabbits. | 1981 | Contraception | pmid:7297071 |
| Lawrence SV | Gossypol: a potential male contraceptive? | 1981 | Am Pharm | pmid:7304423 |
| Tso WW and Lee CS | Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. | 1981 | Contraception | pmid:7318437 |
| Liu YX | [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327032 |
| [A preliminary study on gossypol used in gynecology and its mechanism of action (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327033 | |
| Zhou SW | [Clinical use of gossypol in gynecology (author's transl)]. | 1981 | Zhonghua Fu Chan Ke Za Zhi | pmid:7327034 |
| El-Sebae AH et al. | Gossypol as an inducer or inhibitor in Spodoptera littoralis larvae. | 1981 | J Environ Sci Health B | pmid:6454717 |
| Liang DC et al. | [Studies on distribution of 14C-gossypol in subcellular fractions of rat testes and site of gossypol action (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459173 |
| Bi XF et al. | [Preliminary study on gossypol in causing hypokalemia (author's transl)]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459178 |
| Shi QX et al. | [Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)]. | 1981 | Zhongguo Yao Li Xue Bao | pmid:6462027 |
| Bi XF et al. | The effect of gossypol on ATPase activity of the kidney. | 1981 | Sci. Sin. | pmid:6266011 |
| Ridley AJ and Blasco L | Testosterone and gossypol effects on human sperm motility. | 1981 | Fertil. Steril. | pmid:6273239 |
| Wu YM et al. | Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. | 1981 | Contraception | pmid:6796329 |
| Hei LS | [Electron-microscopic observations on bioptic testicular tissue of cancerous patients after oral administration of gossypol (author's transl)]. | 1981 | Zhonghua Yi Xue Za Zhi | pmid:6804060 |
| El'chits SV et al. | [Glucoamylase immobilization on silochrome using gossypol]. | 1981 Jan-Feb | Ukr. Biokhim. Zh. | pmid:6259793 |
| Liu GZ | Clinical study of gossypol as a male contraceptive. | 1981 Jul-Sep | Reproduccion | pmid:6793420 |
| Kalla NR and Vasudev M | Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. | 1981 Mar-Apr | Andrologia | pmid:6454365 |
| Kalla NR et al. | Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. | 1981 May-Jun | Andrologia | pmid:6455943 |
| Lee CY et al. | Enzyme inactivation and inhibition by gossypol. | 1982 | Mol. Cell. Biochem. | pmid:7144742 |
| Tang F et al. | Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins. | 1982 | Contraception | pmid:7160182 |
| Montamat EE et al. | Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. | 1982 | Science | pmid:6750791 |
| Johnsen O et al. | Gossypol; a potent inhibitor of human sperm acrosomal proteinase. | 1982 | Int. J. Androl. | pmid:6761275 |