| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xue S | [A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903461 |
| Wang L et al. | [Combined use of steroid hormone and low dose gossypol for antifertility and its mechanism in rats]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903462 |
| Cao J et al. | [Effect of low dose gossypol treatment on male sperm nuclear basic protein]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903463 |
| Dabrowski K et al. | Effects of diets containing gossypol on reproductive capacity of rainbow trout (Oncorhynchus mykiss). | 2000 | Biol. Reprod. | pmid:10642557 |
| Rinchard J et al. | Effects of gossypol on sperm viability and plasma sex steroid hormones in male sea lamprey, Petromyzon marinus. | 2000 | Toxicol. Lett. | pmid:10643862 |
| Heiser V et al. | Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10829068 |
| Coutinho EM et al. | Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study. | 2000 | Contraception | pmid:10745071 |
| Chenoweth PJ et al. | Characterization of gossypol-induced sperm abnormalities in bulls. | 2000 | Theriogenology | pmid:10798496 |
| Jan CR et al. | Novel effects of gossypol, a chemical contraceptive in man: mobilization of internal Ca(2+) and activation of external Ca(2+) entry in intact cells. | 2000 | Biochim. Biophys. Acta | pmid:10771095 |
| Shelley MD et al. | Structure-activity studies on gossypol in tumor cell lines. | 2000 | Anticancer Drugs | pmid:10831280 |
| Quintana PJ et al. | Gossypol-induced DNA breaks in rat lymphocytes are secondary to cytotoxicity. | 2000 | Toxicol. Lett. | pmid:11033237 |
| Gupta GS and Syal N | Newly exposed immunochemically cross-reactive epitopes in sperm-specific LDH after glucosylation and gossypol interaction. | 2000 | Am. J. Reprod. Immunol. | pmid:11125794 |
| Wang X and Plhak LC | Production, characterization, and application of anti-gossypol polyclonal antibodies. | 2000 | J. Agric. Food Chem. | pmid:11087445 |
| Bailey CA et al. | Cottonseed with a high (+)- to (-)-gossypol enantiomer ratio favorable to broiler production. | 2000 | J. Agric. Food Chem. | pmid:11087540 |
| Noftsger SM et al. | Effect of whole and expanded-expelled cottonseed on milk yield and blood gossypol. | 2000 | J. Dairy Sci. | pmid:11104273 |
| Wang X et al. | Cytotoxic effect of gossypol on colon carcinoma cells. | 2000 | Life Sci. | pmid:11105982 |
| Dao VT et al. | Synthesis and cytotoxicity of gossypol related compounds. | 2000 | Eur J Med Chem | pmid:11006482 |
| Razakantoanina V et al. | Antimalarial activity of new gossypol derivatives. | 2000 | Parasitol. Res. | pmid:10952267 |
| Nagalakshmi D et al. | Pathological lesions in lambs fed raw or processed cottonseed meal. | 2000 | Vet. Res. Commun. | pmid:10868552 |
| Luginbuhl JM et al. | Effect of level of whole cottonseed on intake, digestibility, and performance of growing male goats fed hay-based diets. | 2000 | J. Anim. Sci. | pmid:10875652 |
| Vander Jagt DL et al. | Gossypol: prototype of inhibitors targeted to dinucleotide folds. | 2000 | Curr. Med. Chem. | pmid:10702620 |
| Abe Y et al. | Altered vascular response to acetylcholine in conditions of endothelial damage in the isolated perfused rat stomach. | 2000 | J. Gastroenterol. | pmid:10680663 |
| Li AS et al. | DNA-breaking versus DNA-protecting activity of four phenolic compounds in vitro. | 2000 | Free Radic. Res. | pmid:11200088 |
| Gu ZP et al. | Low dose gossypol for male contraception. | 2000 | Asian J. Androl. | pmid:11202417 |
| Yuan YY and Shi QX | Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity. | 2000 | Contraception | pmid:11137075 |
| Matsuo M | Preference of female students for "tempe" preparations composed of glandless cottonseed and defatted soybean or corn at various ratios. | 2000 | J. Nutr. Sci. Vitaminol. | pmid:11185660 |
| Adekunle AO et al. | Seminal plasma zinc level in users of gossypol. | 1999 Mar-Jun | Afr J Med Med Sci | pmid:12953977 |
| Cerelli JS and Johnson L | Potential daily sperm production, Sertoli cell number, and seminiferous tubule characteristics in beef bulls fed conventional or gossypol-enriched diets. | 1999 Jul-Aug | J. Androl. | pmid:10452596 |
| Balci A et al. | Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. | 1999 | Tohoku J. Exp. Med. | pmid:10622208 |
| Taitzoglou IA et al. | Gossypol-induced inhibition of plasminogen activator activity in human and ovine acrosomal extract. | 1999 | Andrologia | pmid:10643510 |
| Sharma S et al. | Reversible antispermatogenic effect of gossypol in langur monkeys (Presbytis entellus entellus). | 1999 | Adv Contracept | pmid:10794043 |
| Javed MH and Khan MA | Effect of amino acids on inhibition of lactate dehydrogenase-X by gossypol. | 1999 | Exp. Mol. Med. | pmid:10231019 |
| Tosukhowong P et al. | Environmental distal renal tubular acidosis in Thailand: an enigma. | 1999 | Am. J. Kidney Dis. | pmid:10352213 |
| Deck LM et al. | Inhibition of aldose reductase by gossypol and gossypol-related compounds. | 1999 | Adv. Exp. Med. Biol. | pmid:10352723 |
| Meng YL et al. | Coordinated accumulation of (+)-delta-cadinene synthase mRNAs and gossypol in developing seeds of Gossypium hirsutum and a new member of the cad1 family from G. arboreum. | 1999 | J. Nat. Prod. | pmid:10075752 |
| Shelley MD et al. | Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines. | 1999 | Cancer Lett. | pmid:10096426 |
| Vranová J et al. | Inhibitory effect of gossypol on basal and luteinization factor-stimulated progesterone synthesis in porcine granulosa cells. | 1999 | Physiol Res | pmid:10534015 |
| Bushunow P et al. | Gossypol treatment of recurrent adult malignant gliomas. | 1999 | J. Neurooncol. | pmid:10448875 |
| Velasquez-Pereira J et al. | Long-term effects of feeding gossypol and vitamin E to dairy calves. | 1999 | J. Dairy Sci. | pmid:10386310 |
| Bernard JK et al. | Effect of coating whole cottonseed on performance of lactating dairy cows. | 1999 | J. Dairy Sci. | pmid:10386315 |
| Shibatani M et al. | Accumulation of Isohemigossypolone and Its Related Compounds in the Inner Bark and Heartwood of Diseased Pachira aquatica. | 1999 | Biosci. Biotechnol. Biochem. | pmid:26300168 |
| Waites GM | The contribution of Asian scientists to global research in andrology. | 1999 | Asian J. Androl. | pmid:11225908 |
| Shi A et al. | [Screening and breeding of highly-effected degrading cotton-phenol strains and study on defoxication technology and conditions]. | 1998 | Wei Sheng Wu Xue Bao | pmid:12549423 |
| Michael AE | 11 beta HSD and the mechanism of gossypol-induced hypokalemia. | 1998 | Int. J. Androl. | pmid:9805249 |
| Chan WK et al. | Effects of alpha-tocopherol on metmyoglobin formation and reduction in beef from cattle fed soybean or cottonseed meal diets. | 1998 | J. Anim. Sci. | pmid:9621948 |
| Monsees TK et al. | Influence of gossypol on the secretory function of cultured rat sertoli cells. | 1998 | Toxicon | pmid:9655644 |
| Frick J et al. | [A pill for the man? Current status of fertility control in the man]. | 1998 | Gynakol Geburtshilfliche Rundsch | pmid:9658718 |
| Velasquez-Pereira J et al. | Long-term effects of gossypol and vitamin E in the diets of dairy bulls. | 1998 | J. Dairy Sci. | pmid:9785239 |
| Prost J et al. | Digestion and absorption rates of [3H]-oleic acid and [14C]-triolein do not differ in rats fed heated (-) and (+) gossypol cottonseed and soybean flours. | 1998 | J. Nutr. | pmid:9808656 |
| Guo J and Reidenberg MM | Inhibition of 11beta-hydroxysteroid dehydrogenase by bioflavonoids and their interaction with furosemide and gossypol. | 1998 | J. Lab. Clin. Med. | pmid:9665369 |
| Velasquez-Pereira J et al. | Effects on performance, tissue integrity, and metabolism of vitamin E supplementation for beef heifers fed a diet that contains gossypol. | 1998 | J. Anim. Sci. | pmid:9856398 |
| Velasquez-Pereira J et al. | Reproductive effects of feeding gossypol and vitamin E to bulls. | 1998 | J. Anim. Sci. | pmid:9856400 |
| Achudume AC et al. | Experimental analysis of gossypol and chloroquine interaction in serum and in liver of rat. | 1998 | Indian J. Exp. Biol. | pmid:10356961 |
| Teng CS and Vilagrasa X | Biphasic c-Myc protein expression during gossypol-induced apoptosis in rat spermatocytes. | 1998 | Contraception | pmid:9589839 |
| Hutchinson RW et al. | Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9707507 |
| Teng CS | c-fos protein expression in apoptotic rat spermatocytes induced by gossypol. | 1998 | Contraception | pmid:9649921 |
| Yu ZH and Chan HC | Gossypol as a male antifertility agent--why studies should have been continued. | 1998 | Int. J. Androl. | pmid:9639145 |
| Waites GM et al. | Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. | 1998 | Int. J. Androl. | pmid:9639146 |
| Hutchinson RW et al. | Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells. | 1998 | Cell Biol. Toxicol. | pmid:9879931 |
| Blackwelder JT et al. | Milk production and plasma gossypol of cows fed cottonseed and oilseed meals with or without rumen-undegradable protein. | 1998 | J. Dairy Sci. | pmid:9839237 |
| Zhang Y et al. | The (-)-enantiomer of gossypol inhibits proliferation of stromal cells derived from human breast adipose tissues by enhancing transforming growth factor beta1 production. | 1998 | Int. J. Oncol. | pmid:9824647 |
| Wu F et al. | [Comparative study on the effect of gossypol and T7 on human spermatozoa ATPase activity]. | 1998 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:11367690 |
| Shidaifat F et al. | Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle. | 1997 Mar-Apr | Anticancer Res. | pmid:9137441 |
| Akingbemi BT et al. | Chronic ethanol intake may delay the onset of gossypol-induced infertility in the male rat. | 1997 Jul-Aug | Andrologia | pmid:9263570 |
| Akingbemi BT et al. | The influence of protein malnutrition on the antifertility action of gossypol in the Trypanosoma brucei-infected rat: some ultrastructural observations from the testis. | 1997 Jul-Aug | Reprod. Toxicol. | pmid:9241673 |
| Gupta GS and Kang BP | Quenching of intrinsic fluorescence of sperm specific LDH by optical isomers of gossypol. | 1997 | Gen. Physiol. Biophys. | pmid:9452944 |
| Kumar M et al. | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. | 1997 | Contraception | pmid:9408707 |
| Bernard JK and Calhoun MC | Response of lactating dairy cows to mechanically processed whole cottonseed. | 1997 | J. Dairy Sci. | pmid:9313148 |
| Brocas C et al. | Deleterious actions of gossypol on bovine spermatozoa, oocytes, and embryos. | 1997 | Biol. Reprod. | pmid:9314596 |
| Blackstaffe L et al. | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. | 1997 | Melanoma Res. | pmid:9429219 |
| Tran PT et al. | Effect of gossypol on Spisula sperm observed with real-time confocal microscopy, polarized light microscopy, and video microscopy. | 1997 | Biol. Bull. | pmid:9390392 |
| Ligueros M et al. | Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. | 1997 | Br. J. Cancer | pmid:9218727 |
| Kalla NR et al. | alpha-Glucosidase activity in the rat epididymis under different physiological conditions. | 1997 | Int. J. Androl. | pmid:9292319 |
| Deoras DP et al. | Effect of gossypol on hepatic and serum gamma-glutamyltransferase activity in rats. | 1997 | Vet. Res. Commun. | pmid:9232775 |
| Sessions RB et al. | A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia. | 1997 | Protein Eng. | pmid:9194154 |
| Chang WY et al. | Gossypol induces spermidine/spermine N1-acetyltransferase in canine prostate epithelial cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070284 |
| Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9115008 |
| González-Garza MT et al. | Gossypol anti-amebic effect in vivo. | 1997 | Arch. Med. Res. | pmid:9033108 |
| Cruz-Vega DE et al. | Determination of the antiamebic effect of a metronidazole/gossypol blend. | 1997 | Arch. Med. Res. | pmid:9033109 |
| Soubeyrand S et al. | Purification of a novel phospholipase A2 from bovine seminal plasma. | 1997 | J. Biol. Chem. | pmid:8995251 |
| Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9013060 |
| Rekha GK and Sladek NE | Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol. | 1997 | Adv. Exp. Med. Biol. | pmid:9059615 |
| Gomez MS et al. | Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum. | 1997 | Mol. Biochem. Parasitol. | pmid:9497046 |
| Yu BZ et al. | Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates. | 1997 | Biochemistry | pmid:9376343 |
| Blauwiekel R et al. | Effect of whole cottonseed, gossypol, and ruminally protected lysine supplementation on milk yield and composition. | 1997 | J. Dairy Sci. | pmid:9241597 |
| Wang MS et al. | NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10322899 |
| Chen Y et al. | [Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice]. | 1997 | Yao Xue Xue Bao | pmid:11596197 |
| Yang B et al. | [The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts]. | 1997 | Yao Xue Xue Bao | pmid:11596304 |
| Akingbemi BT et al. | Ethanol intake may modify gossypol toxicosis in the rat. | 1996 Sep-Oct | J Appl Toxicol | pmid:8889787 |
| Wu Y et al. | Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy. | 1996 | Biophys. J. | pmid:8804592 |
| Wu T et al. | [Effects of gossypol acetic acid on human ejaculated sperm Ca2+ influx and rat vas deferens contraction action]. | 1996 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:9388965 |
| Ye WS et al. | [The antifertility effect of gossypol plus testosterone and estrogen]. | 1996 | Yao Xue Xue Bao | pmid:9208651 |
| Achudume AC and Eno TL | Characterization of ion interference in gossypol consumption. | 1996 | Adv Contracept | pmid:8910664 |
| Hervé JC et al. | Contraceptive gossypol blocks cell-to-cell communication in human and rat cells. | 1996 | Eur. J. Pharmacol. | pmid:8911921 |
| Shidaifat F et al. | Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. | 1996 | Cancer Lett. | pmid:8913264 |
| Szücs G et al. | Characterization of volume-activated chloride currents in endothelial cells from bovine pulmonary artery. | 1996 | J. Membr. Biol. | pmid:8801351 |
| Guan MZ and Wang NG | [Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats]. | 1996 | Yao Xue Xue Bao | pmid:8762457 |
| Chang WY et al. | Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8827831 |
| Mushtaq M et al. | Gossypol inhibits human chorionic gonadotropin-stimulated testosterone production by cultured canine testicular interstitial cells. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8829766 |
| Graier WF et al. | High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions. | 1996 | Diabetes | pmid:8826976 |