Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Morris ID Gossypol: a male contraceptive with potential? 1986 IRCS J Med Sci pmid:12280996
Wu GP [Gossypol and its related compounds as contraceptive drugs and drugs for gynecological diseases]. 1988 Shengzhi Yu Biyun pmid:12282152
Baram N et al. Inactivation of intestinal brush-border enzymes by gossypol. 1987 Agric. Biol. Chem. pmid:12283503
Bialy G and Alexander NJ Developments in male contraception. 1992 Health Sex pmid:12286189
Yu ZH and Chan HC Gossypol and hypokalemia: a critical review. 1994 Adv Contracept Deliv Syst pmid:12289957
Xiao B and Wang M Birth control techniques in China. 1983 China Popul Newsl pmid:12312957
Zhong CQ [The morphology and formation of micronuclei of blood lymphocytes in man after cessation of gossypol administration]. 1986 Shengzhi Yu Biyun pmid:12314624
Tung DS et al. Effect of long term gossypol treatment on human testicular structure. 1987 Adv Contracept Deliv Syst pmid:12314752
Zhong CQ [Studies on sperm function in man long after cessation of gossypol administration]. 1988 Shengzhi Yu Biyun pmid:12315492
Wang YX and Chen ZX [A possible mechanism of gossypol-induced hypokalemia and its relation to gossypol dose]. 1991 Shengzhi Yu Biyun pmid:12317367
Herndon N Looking for the "male pill". 1992 Netw Res Triangle Park N C pmid:12317724
Yuan JR [Methods of extraction and purification of gossypol]. 1984 Shengzhi Yu Biyun pmid:12339570
Zheng DK et al. Resolution of racemic gossypol. 1985 J. Chem. Soc. Chem. Commun. pmid:12340526
Gonzales-garza MT et al. Cytotoxic effects of gossypol and vitamin E on human and rat lymphocytes and spermatozoa. 1985 Nutr Rep Int pmid:12340733
Goldstein M The future of male birth control. 1986 Plan Parent Rev pmid:12340896
Wang R [Sister chromatid exchanges in gossypol formic acid users after its discontinuation]. 1986 Shengzhi Yu Biyun pmid:12341303
Andrade AT [Information on advances in sciences and technology. Advances in contraceptive technology]. 1993 Bol Cent Biol Reprod pmid:12345521
Velasquez-Pereira J et al. Effects of gossypol from cottonseed meal and dietary vitamin E on the reproductive characteristics of superovulated beef heifers. 2002 J. Anim. Sci. pmid:12350026
Lee KJ and Dabrowski K High-performance liquid chromatographic determination of gossypol and gossypolone enantiomers in fish tissues using simultaneous electrochemical and ultraviolet detectors. 2002 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:12361745
Pandey SN and Thejappa N Study on relationship between oil, protein, and gossypol in cottonseed kernels. 1975 J Am Oil Chem Soc pmid:1242138