Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

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Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Qian SZ and Wang ZG Gossypol: a potential antifertility agent for males. 1984 Annu. Rev. Pharmacol. Toxicol. pmid:6375548
Sonpavde G et al. Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. 2012 Ann. Oncol. pmid:22112969
Johnson PW New targets for lymphoma treatment. 2008 Ann. Oncol. pmid:18519406
Chadha S et al. Alterations and reversibility of the effects of gossypol acetic acid on the intestinal uptake of end product nutrients in normal and protein calorie-malnourished male rats. 1991 Ann. Nutr. Metab. pmid:1905512
Tvermyr SM et al. Glucose metabolism in rat germ cells: mechanism of action of gossypol. 1984 Ann. N. Y. Acad. Sci. pmid:6598341
Fody EP and Walker EM Effects of drugs on the male and female reproductive systems. 1985 Nov-Dec Ann. Clin. Lab. Sci. pmid:4062226
Kunesch N et al. [Preparation of derivatives of the aldehydic functions of gossypol]. 1990 Ann Pharm Fr pmid:2082795
Cornu A et al. [Utilization of gossypol-free cottonseed and its by-products as human food]. 1977 Ann Nutr Aliment pmid:579293
Ojha P et al. Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. 2008 Anim. Reprod. Sci. pmid:17207942
Price CP et al. Dissecting the behavior of a promiscuous solvate former. 2006 Angew. Chem. Int. Ed. Engl. pmid:16493716
Weinbauer GF et al. The endocrine status of gossypol - treated male rats. 1983 Andrologia pmid:6421193
Weinbauer GF et al. Antifertility efficacy of gossypol acetic acid in male rats. 1982 May-Jun Andrologia pmid:7114507
Wang JM et al. Electrolyte composition of rete testis fluid and cauda epididymal plasma and spermatozoa from rats following gossypol treatment. 1986 Jan-Feb Andrologia pmid:3954086
Taitzoglou IA et al. Gossypol-induced inhibition of plasminogen activator activity in human and ovine acrosomal extract. 1999 Andrologia pmid:10643510
Kalla NR and Vasudev M Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. 1981 Mar-Apr Andrologia pmid:6454365
Kalla NR et al. Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. 1981 May-Jun Andrologia pmid:6455943
Ikeda M Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid. 1990 Sep-Oct Andrologia pmid:2073051
Akingbemi BT et al. Chronic ethanol intake may delay the onset of gossypol-induced infertility in the male rat. 1997 Jul-Aug Andrologia pmid:9263570
Levinsky H et al. Inhibition of sialyl transferase activity by gossypol acetic acid in human seminal plasma. 1991 Mar-Apr Andrologia pmid:1952122
Nakamura M et al. Metabolism of round spermatids in the rat: effect of gossypol on the glucose transport. 1988 Sep-Oct Andrologia pmid:3207199