| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Puckhaber LS et al. | Toxicity of (+)- and (-)-gossypol to the plant pathogen, Rhizoctonia solani. | 2002 | J. Agric. Food Chem. | pmid:12428953 |
| Phillis JW et al. | Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. | 2002 | Brain Res. | pmid:12443975 |
| Le Blanc M et al. | An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines. | 2002 | Pharmacol. Res. | pmid:12457630 |
| Kuhn G et al. | Gossypol induces chloride secretion in rat proximal colon. | 2002 | Eur. J. Pharmacol. | pmid:12464365 |
| NarovlianskiÄ AN et al. | [Effect of interferon inductors on infection induced by hepatitis C virus and activity of mRNA cytokines in cell cultures SW-13 and MT-4]. | 2002 Nov-Dec | Vopr. Virusol. | pmid:12508677 |
| Shi YL et al. | Ion-channels in human sperm membrane and contraceptive mechanisms of male antifertility compounds derived from Chinese traditional medicine. | 2003 | Acta Pharmacol. Sin. | pmid:12511225 |
| Risco CA et al. | Effects of gossypol from cottonseed on hematological responses and plasma alpha-tocopherol concentration of dairy cows. | 2002 | J. Dairy Sci. | pmid:12512612 |
| Freedman TB et al. | Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism. | 2003 | Chirality | pmid:12520512 |
| Tone JN and Jensen DR | The accumulation pattern of ingested gossypol in selected organs of the rat. | 1976 | Experientia | pmid:1253913 |
| Keller PA et al. | Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor. | 2003 | J. Mol. Graph. Model. | pmid:12543135 |
| Shi A et al. | [Screening and breeding of highly-effected degrading cotton-phenol strains and study on defoxication technology and conditions]. | 1998 | Wei Sheng Wu Xue Bao | pmid:12549423 |
| Mego M | Telomerase inhibitors in anticancer therapy: gossypol as a potential telomerase inhibitor. | 2002 | Bratisl Lek Listy | pmid:12583508 |
| Bai JP et al. | Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction. | 2003 | Eur. J. Pharmacol. | pmid:12600689 |
| Prieto JG et al. | Increasing dietary levels of cracked pima cottonseed increase plasma gossypol but do not influence productive performance of lactating Holstein cows. | 2003 | J. Dairy Sci. | pmid:12613869 |
| Dao VT et al. | New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents. | 2003 | Bioorg. Med. Chem. | pmid:12670651 |
| Vershinina MY et al. | Regulation of cytokine mRNAs by interferon and interferon inducers. | 2002 | Russ. J. Immunol. | pmid:12687259 |
| Santos JE et al. | Type of cottonseed and level of gossypol in diets of lactating dairy cows: plasma gossypol, health, and reproductive performance. | 2003 | J. Dairy Sci. | pmid:12703626 |
| Dowd MK | Preparation of enantiomeric gossypol by crystallization. | 2003 | Chirality | pmid:12774287 |
| Cui GH et al. | [Determination of gossypol in cotton root bark by HPLC]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774395 |
| Zhang M et al. | Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. | 2003 | Biochem. Pharmacol. | pmid:12818369 |