| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Politzer WM | Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol). | 2008 | Phytomedicine | pmid:18573644 |
| Shaaban WF et al. | Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma. | 2008 | Fertil. Steril. | pmid:17953964 |
| Li ZM et al. | Synergistic cytotoxicity of Bcl-xL inhibitor, gossypol and chemotherapeutic agents in non-Hodgkin's lymphoma cells. | 2008 | Cancer Biol. Ther. | pmid:17938578 |
| Sprogøe K et al. | Combining HPLC-PDA-MS-SPE-NMR with circular dichroism for complete natural product characterization in crude extracts: levorotatory gossypol in Thespesia danis. | 2008 | J. Nat. Prod. | pmid:18290629 |
| Paoluzzi L et al. | Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. | 2008 | Blood | pmid:18292288 |
| Przybylski P et al. | CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. | 2008 | Magn Reson Chem | pmid:18338327 |
| Zha SW et al. | [Male antifertility drugs and cell apoptosis]. | 2008 | Zhonghua Nan Ke Xue | pmid:18297819 |
| RodrÃguez-EnrÃquez S et al. | Energy metabolism transition in multi-cellular human tumor spheroids. | 2008 | J. Cell. Physiol. | pmid:18264981 |
| Arnold AA et al. | Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. | 2008 | Mol. Cancer | pmid:18275607 |
| Sikora MJ et al. | Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. | 2008 | Cancer Biol. Ther. | pmid:18376141 |
| Moon DO et al. | Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. | 2008 | FEBS Lett. | pmid:18775705 |
| Przybylski P et al. | Molecular structures and stability constants of gossypol and its aza-derivative complexes with silver(I) cations studied by potentiometric, ESI MS, NMR, and AM1d semiempirical methods. | 2008 | J Phys Chem A | pmid:18698745 |
| Boonsri S et al. | Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. | 2008 | J. Nat. Prod. | pmid:18553924 |
| Zhou DR et al. | Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43. | 2008 | Toxicol In Vitro | pmid:18706992 |
| Trischitta F and Faggio C | Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla. | 2008 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:18606239 |
| Etxebarria A et al. | Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. | 2008 | Biochem. Pharmacol. | pmid:18762177 |
| Tang Y et al. | [Progress in small-molecule inhibitors of Bcl-2 family proteins]. | 2008 | Yao Xue Xue Bao | pmid:18819468 |
| Gong YZ et al. | Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. | 2008 | Eur. J. Pharmacol. | pmid:18930721 |
| Sun J et al. | ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. | 2008 | Anticancer Drugs | pmid:18827561 |
| Cui G et al. | Gossypol with methyltestosterone and ethinylestradiol male does not affect rat spermatogonial stem cell differentiation. | 2007 Mar-Apr | Arch. Androl. | pmid:17453689 |
| Ye W et al. | Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. | 2007 Jan-Feb | Anticancer Res. | pmid:17352222 |
| Meng Y et al. | (-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. | 2007 | Leuk. Lymphoma | pmid:17926190 |
| Mao YB et al. | Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. | 2007 | Nat. Biotechnol. | pmid:17982444 |
| Lordelo MM et al. | Relative toxicity of gossypol enantiomers in laying and broiler breeder hens. | 2007 | Poult. Sci. | pmid:17297172 |
| Zhang M et al. | Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. | 2007 | Clin. Exp. Pharmacol. Physiol. | pmid:17250644 |
| Leyman A et al. | The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts. | 2007 | Cell. Signal. | pmid:17355905 |
| Costantino A et al. | Current status and future perspectives in male contraception. | 2007 | Minerva Ginecol | pmid:17576406 |
| Tang G et al. | Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. | 2007 | J. Med. Chem. | pmid:17552510 |
| Ko CH et al. | Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. | 2007 | Int. J. Cancer | pmid:17597109 |
| Wolter KG et al. | Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. | 2007 | Cell Death Differ. | pmid:17541428 |
| Kasten-Pisula U et al. | Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. | 2007 | Radiother Oncol | pmid:17521756 |
| Feng BY et al. | A high-throughput screen for aggregation-based inhibition in a large compound library. | 2007 | J. Med. Chem. | pmid:17447748 |
| Badawy SZ et al. | Gossypol inhibits proliferation of endometrioma cells in culture. | 2007 | Asian J. Androl. | pmid:17486280 |
| Orth RG et al. | Determining larval host plant use by a polyphagous lepidopteran through analysis of adult moths for plant secondary metabolites. | 2007 | J. Chem. Ecol. | pmid:17492366 |
| Choi SR et al. | Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. | 2007 | J. Med. Chem. | pmid:17636950 |
| Loberg RD et al. | In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. | 2007 | Neoplasia | pmid:18084610 |
| Turco E et al. | The in vitro effect of gossypol and its interaction with salts on conidial germination and viability of Fusarium oxysporum sp. vasinfectum isolates. | 2007 | J. Appl. Microbiol. | pmid:18045422 |
| Akinola OB et al. | Spermatoprotective activity of the leaf extract of Psidium guajava Linn. | 2007 | Niger Postgrad Med J | pmid:18163132 |
| Gerasimidis K et al. | Preparation of an edible cottonseed protein concentrate and evaluation of its functional properties. | 2007 | Int J Food Sci Nutr | pmid:17710592 |
| Carruthers NJ et al. | Gossypol inhibits calcineurin phosphatase activity at multiple sites. | 2007 | Eur. J. Pharmacol. | pmid:17141216 |
| Liu F et al. | Pharmacophore identification of KSP inhibitors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17095225 |
| Zhang M et al. | Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways. | 2007 | Life Sci. | pmid:17156797 |
| Song JJ et al. | Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. | 2007 | J. Biol. Chem. | pmid:17110373 |
| Xing C et al. | Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. | 2007 | Bioorg. Med. Chem. | pmid:17227711 |
| Lv G et al. | [The effect of gossypol, praziquantel and artemether on recombinant lactate dehydrogenase from Schistosoma japonicum]. | 2007 | Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi | pmid:18441994 |
| Denisov AY et al. | Heat-induced dimerization of BCL-xL through alpha-helix swapping. | 2007 | Biochemistry | pmid:17223694 |
| Makkar HP et al. | Plant secondary metabolites. | 2007 | Methods Mol. Biol. | pmid:19238775 |
| Huang YW et al. | Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. | 2006 Sep-Oct | Anticancer Res. | pmid:17094491 |
| Huang YW et al. | Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. | 2006 May-Jun | Anticancer Res. | pmid:16827126 |
| Akinola OB et al. | Proteinaceous diet inhibits gossypol-induced spermatotoxicity. | 2006 Jul-Sep | Eur J Histochem | pmid:16920644 |