Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Sagach VF et al. Functional hyperemia of skeletal muscle: role of endothelium. 1992 J. Cardiovasc. Pharmacol. pmid:1282960
Tkachenko MN et al. Involvement of endothelium in vasodilating effects of vintoperol. 1992 J. Cardiovasc. Pharmacol. pmid:1282997
Dowd MK and Stevens ED The gossypol-cyclododecanone (1/2) inclusion complex. 2003 Acta Crystallogr C pmid:12855869
Kawanishi K et al. Aldose reductase inhibitors from the nature. 2003 Curr. Med. Chem. pmid:12871134
Räsänen TL et al. Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. 2003 Scand. J. Gastroenterol. pmid:12889567
Xue S [A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception]. 2000 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:12903461
Wang L et al. [Combined use of steroid hormone and low dose gossypol for antifertility and its mechanism in rats]. 2000 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:12903462
Cao J et al. [Effect of low dose gossypol treatment on male sperm nuclear basic protein]. 2000 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:12903463
Zaidi R and Hadi SM Complexes involving gossypol, DNA and Cu(II). 1992 Biochem. Int. pmid:1290468
Jo C et al. Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in methanol. 2003 Food Chem. Toxicol. pmid:12909266
Zaidi R and Hadi SM Strand scission in DNA by gossypol and Cu(II): role of Cu(I) and oxygen-free radicals. 1992 J. Biochem. Toxicol. pmid:1293310
Wang YH et al. 8-Hydroxy-(+)-delta-cadinene is a precursor to hemigossypol in Gossypium hirsutum. 2003 Phytochemistry pmid:12946420
Adekunle AO et al. Seminal plasma zinc level in users of gossypol. 1999 Mar-Jun Afr J Med Med Sci pmid:12953977
Yurtcu E et al. Apoptotic effect of gossypol on human lymphocytes. 2003 Cell Biol. Int. pmid:12972286
Franklin RB et al. Prolactin stimulates transcription of aspartate aminotransferase in prostate cells. 1992 Mol. Cell. Endocrinol. pmid:1301396
Chang SM et al. [Effect of gossypol on the proliferation of rat prostate cells studies in vivo and in vitro]. 1992 Shi Yan Sheng Wu Xue Bao pmid:1303003
CASTILLON LE et al. Preparation of combination products of gossypol with glycine and dextrose and their toxicity toward mice. 1953 Arch. Biochem. Biophys. pmid:13058367
Udoh P and Patil DR Effects of gossypol acetate on pituitary-adrenal axis in male albino rats. 1992 Contraception pmid:1324828
SMITH HA The pathology of gossypol poisoning. 1957 Mar-Apr Am. J. Pathol. pmid:13402891
González-Garza MT et al. Further studies on the in vitro activity of gossypol as antiamebic agent. 1992 Arch. Med. Res. pmid:1340324