Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cattle Diseases D002418 24 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Jarvis WD et al. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. 1994 Cancer Res. pmid:7511048
Inoue H et al. Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. 1993 Br. J. Pharmacol. pmid:7508328
Waller DP et al. In vitjro spermicidal activity of gossypol. 1980 Contraception pmid:7449381
Cheng KF et al. Endometrial changes after administration of gossypol for menorrhagia. 1980 Am. J. Obstet. Gynecol. pmid:7446637
Coulson PB et al. Short term metabolic effects of the anti-fertility agent, gossypol, on various reproductive organs of male mice. 1980 Int. J. Androl. pmid:7440012
Vagabov RM et al. [Comparative study of the effectiveness of the interferon inducers, poly(I) : poly(C) and GSS (gossypol-beta-aminoethylsodium sulfate), in combination with a specific vaccine in experimental infection with the human acute encephalomyelitis virus]. 1980 May-Jun Vopr. Virusol. pmid:7434726
Chang MC et al. Effects of Gossypol on the fertility of male rats, hamsters and rabbits. 1980 Contraception pmid:7428357
Shepu X et al. Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. 1980 Sci. Sin. pmid:7403840
Wen W China invents male birth control pill. 1980 Spring-Summer Am. J. Chin. Med. pmid:7395797
Abidov MM et al. [Effect of the immunodepressive preparation, batriden, on the course of experimental allergic dermatitis]. 1980 Vestn Dermatol Venerol pmid:7376717
Muratov MM et al. [Hygienic evaluation of acetate fabric dyed with technical grade gossypol]. 1980 Gig Sanit pmid:7372107
Zhou SW [Clinical use of gossypol in gynecology (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327034
[A preliminary study on gossypol used in gynecology and its mechanism of action (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327033
Liu YX [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327032
Tso WW and Lee CS Variations of gossypol sensitivity in boar spermatozoal electron transport chain segments. 1981 Contraception pmid:7318437
Lawrence SV Gossypol: a potential male contraceptive? 1981 Am Pharm pmid:7304423
Sakesena SK et al. Gossypol: its toxicological and endocrinological effects in male rabbits. 1981 Contraception pmid:7297071
Waller DP et al. Antifertility effects of gossypol and its impurities on male hamsters. 1981 Contraception pmid:7285581
Hahn DW et al. Antifertility and endocrine activities of gossypol in rodents. 1981 Contraception pmid:7273769
Bozek SA et al. Scanning electron microscopic study of spermatozoa from gossypol-treated rats. 1981 Cell Tissue Res. pmid:7273120