Meng Y et al. |
Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. |
2008 |
Mol. Cancer Ther. |
pmid:18645028
|
Lian J et al. |
Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation. |
2012 |
Mol. Cancer Ther. |
pmid:22188816
|
Billard C |
BH3 mimetics: status of the field and new developments. |
2013 |
Mol. Cancer Ther. |
pmid:23974697
|
Volate SR et al. |
Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. |
2010 |
Mol. Cancer Ther. |
pmid:20124455
|
Billard C |
Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia. |
2012 |
Mol. Cancer Res. |
pmid:22466256
|
Voss V et al. |
The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma. |
2010 |
Mol. Cancer Res. |
pmid:20587533
|
Amm HM et al. |
Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. |
2011 |
Mol. Cancer Res. |
pmid:21357440
|
Arnold AA et al. |
Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. |
2008 |
Mol. Cancer |
pmid:18275607
|
Cengiz E et al. |
Overcoming drug resistance in hormone- and drug-refractory prostate cancer cell line, PC-3 by docetaxel and gossypol combination. |
2010 |
Mol. Biol. Rep. |
pmid:19288219
|
Karaca B et al. |
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. |
2013 |
Mol. Biol. Rep. |
pmid:23269627
|
Bork S et al. |
Identification of Babesia bovis L-lactate dehydrogenase as a potential chemotherapeutical target against bovine babesiosis. |
2004 |
Mol. Biochem. Parasitol. |
pmid:15478796
|
Conners R et al. |
Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. |
2005 |
Mol. Biochem. Parasitol. |
pmid:15978953
|
Gomez MS et al. |
Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum. |
1997 |
Mol. Biochem. Parasitol. |
pmid:9497046
|
Dando C et al. |
The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum. |
2001 |
Mol. Biochem. Parasitol. |
pmid:11704270
|
Lan L et al. |
Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. |
2015 |
Mol Oncol |
pmid:25933687
|
Baoleri X et al. |
Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. |
2015 |
Mol Med Rep |
pmid:26238307
|
Zhan W et al. |
Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. |
2015 |
Mol Med Rep |
pmid:25672487
|
Zhang X et al. |
Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo. |
2014 |
Mol Med Rep |
pmid:25060748
|
Wang J et al. |
Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. |
2013 |
Mol Biosyst |
pmid:23532321
|
Costantino A et al. |
Current status and future perspectives in male contraception. |
2007 |
Minerva Ginecol |
pmid:17576406
|
Hadley MA and Burgos MH |
Gossypol injected in the rat epididymal fat pad inhibits epididymal sperm motility. |
1986 |
Microsc Electron Biol Celular |
pmid:3587061
|
Makkar HP et al. |
Plant secondary metabolites. |
2007 |
Methods Mol. Biol. |
pmid:19238775
|
Ansari N et al. |
Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy. |
2013 |
Methods Cell Biol. |
pmid:23317907
|
Blackstaffe L et al. |
Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. |
1997 |
Melanoma Res. |
pmid:9429219
|
Semon B |
Dietary intake of cottonseed toxins is hypothesized to be a partial cause of Alzheimer's disorder. |
2012 |
Med. Hypotheses |
pmid:22136946
|
Cheng CC |
A common structural pattern among many biologically active compounds of natural and synthetic origin. |
1986 |
Med. Hypotheses |
pmid:3090407
|
Yurekli B et al. |
Can gossypol be a hope for transsexual patients (male to female) before sex reassignment surgery? Just for adjusting the body to mind. |
2009 |
Med. Hypotheses |
pmid:19647947
|
Harper MJ |
Fertility control. |
1982 Oct-Dec |
Med Res Rev |
pmid:6757597
|
Przybylski P et al. |
CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. |
2008 |
Magn Reson Chem |
pmid:18338327
|
That QT et al. |
Schiff bases of gossypol: an NMR and DFT study. |
2005 |
Magn Reson Chem |
pmid:15678567
|
Abou-Donia MB et al. |
Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats. |
1970 |
Lipids |
pmid:5484207
|
Shandilya LN and Clarkson TB |
Hypolipidemic effects of gossypol in cynomolgus monkeys (Macaca fascicularis). |
1982 |
Lipids |
pmid:6952061
|
Posinovec J |
[Gossypol - the newest agent for the prevention of male fertility]. |
1983 |
Lijec Vjesn |
pmid:6888153
|
Abou-Donia MB and Dieckert JW |
Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. |
1974 |
Life Sci. |
pmid:4277086
|
Lin YC et al. |
Transfer of 3H-gossypol to neonatal rats via milk of nursing dams. |
1992 |
Life Sci. |
pmid:1435075
|
Gilbert NE et al. |
Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. |
1995 |
Life Sci. |
pmid:7596222
|
Wang X et al. |
Cytotoxic effect of gossypol on colon carcinoma cells. |
2000 |
Life Sci. |
pmid:11105982
|
Gu Y et al. |
Inhibitory effect of gossypol on human chorionic gonadotropin (hCG)-induced progesterone secretion in cultured bovine luteal cells. |
1990 |
Life Sci. |
pmid:2168511
|
Benz CC et al. |
Gossypol effects on endothelial cells and tumor blood flow. |
1991 |
Life Sci. |
pmid:1875793
|
Zhang M et al. |
Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways. |
2007 |
Life Sci. |
pmid:17156797
|
Lin YC et al. |
Binding of 3H-gossypol in organelles of cultured bovine luteal cells. |
1992 |
Life Sci. |
pmid:1734162
|
Ye YX et al. |
Modification of the positive inotropic effects of catecholamines, cardiac glycosides and Ca2+ by the orally active male contraceptive, gossypol, in isolated guinea-pig heart. |
1989 |
Life Sci. |
pmid:2557505
|
Lin YC et al. |
Inhibition of in vitro fertilization and early embryonic development in hamsters by gossypol. |
1994 |
Life Sci. |
pmid:8090055
|
Hu YF et al. |
Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells. |
1993 |
Life Sci. |
pmid:8255144
|
Lin YC et al. |
Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats. |
1985 |
Life Sci. |
pmid:4010468
|
Jang GH and Lee M |
BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip¹.). |
2014 |
Life Sci. |
pmid:24625733
|
Soderquist R et al. |
Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. |
2013 |
Leukemia |
pmid:23640104
|
Meng Y et al. |
(-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. |
2007 |
Leuk. Lymphoma |
pmid:17926190
|
Balakrishnan K et al. |
Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. |
2013 |
Leuk. Lymphoma |
pmid:22866921
|
Ni Z et al. |
Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. |
2013 |
Leuk. Lymphoma |
pmid:23398207
|