Phytol is a lipid of Prenol Lipids (PR) class. Phytol is associated with abnormalities such as Simian Acquired Immunodeficiency Syndrome, Hypoglycemia, Refsum Disease, Peripheral Neuropathy and Metabolic Diseases. The involved functions are known as Oxidation, transmethylation, fatty acid oxidation, Lipid Metabolism and chlorophyll catabolic process. Phytol often locates in Mitochondria, Membrane, peroxisome, Cytoplasm and Body tissue. The associated genes with Phytol are ETFDH gene, Homologous Gene, Genome, IMPACT gene and Arabidopsis Proteins. The related lipids are Fatty Acids, Nonesterified Fatty Acids, nonadecanoic acid, branched chain fatty acid and pristanic acid. The related experimental models are Mouse Model.
To understand associated biological information of Phytol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Phytol is suspected in Hepatic necrosis, Refsum Disease, Metabolic Diseases, Congenital absence of external ear, Exencephaly, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Phytol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Sarcoma, Experimental | D012513 | 13 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Hyperplasia | D006965 | 34 associated lipids |
| Fibrosarcoma | D005354 | 8 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Chondrodysplasia Punctata, Rhizomelic | D018902 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Phytol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Effect of SCP-x gene ablation on branched-chain fatty acid metabolism.' (Atshaves BP et al., 2007) and Mouse Model are used in the study 'A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids.' (Savolainen K et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ko GA and Cho SK | Phytol suppresses melanogenesis through proteasomal degradation of MITF via the ROS-ERK signaling pathway. | 2018 | Chem. Biol. Interact. | pmid:29486182 |
| Eraky MA et al. | In Vitro Schistosomicidal Activity of Phytol and Tegumental Alterations Induced in Juvenile and Adult Stages of Schistosoma haematobium. | 2016 | Korean J. Parasitol. | pmid:27658600 |
| Andrade Mdos S et al. | Essential Oil Variation from Twenty Two Genotypes of Citrus in Brazil-Chemometric Approach and Repellency Against Diaphorina citri Kuwayama. | 2016 | Molecules | pmid:27338332 |
| Almeida J et al. | Down-regulation of tomato PHYTOL KINASE strongly impairs tocopherol biosynthesis and affects prenyllipid metabolism in an organ-specific manner. | 2016 | J. Exp. Bot. | pmid:26596763 |
| Mach J | Phytol from Degradation of Chlorophyll Feeds Biosynthesis of Tocopherols. | 2015 | Plant Cell | pmid:26475867 |
| Vom Dorp K et al. | Remobilization of Phytol from Chlorophyll Degradation Is Essential for Tocopherol Synthesis and Growth of Arabidopsis. | 2015 | Plant Cell | pmid:26452599 |
| Mork-Jansson A et al. | Lil3 Assembles with Proteins Regulating Chlorophyll Synthesis in Barley. | 2015 | PLoS ONE | pmid:26172838 |
| PolatoÄŸlu K et al. | DPPH scavenging, PRAP activities and essential oil composition of edible Lathyrus ochrus L. (Cyprus Vetch, Luvana) from Cyprus. | 2015 | J Oleo Sci | pmid:25757435 |
| Chou YL et al. | Purification and immobilization of the recombinant Brassica oleracea Chlorophyllase 1 (BoCLH1) on DIAION®CR11 as potential biocatalyst for the production of chlorophyllide and phytol. | 2015 | Molecules | pmid:25719743 |
| Nakaya S et al. | Characteristic Chemical Components and Aroma-active Compounds of the Essential Oils from Ranunculus nipponicus var. submersus Used in Japanese Traditional Food. | 2015 | J Oleo Sci | pmid:25891110 |