| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Peroxisomal Disorders | D018901 | 5 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Chondrodysplasia Punctata | D002806 | 8 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Retinitis Pigmentosa | D012174 | 6 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Dystonia | D004421 | 3 associated lipids |
Pristanic acid
Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.
Cross Reference
Introduction
To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pristanic acid?
Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Pristanic acid
PubChem Associated disorders and diseases
What pathways are associated with Pristanic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pristanic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Pristanic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Pristanic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Pristanic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Pristanic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Pristanic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Steinberg SJ et al. | Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10198260 |
| Ferdinandusse S et al. | Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10486279 |
| Wanders RJ et al. | Lipid metabolism in peroxisomes: enzymology, functions and dysfunctions of the fatty acid alpha- and beta-oxidation systems in humans. | 2000 | Biochem. Soc. Trans. | pmid:10816116 |
| Zomer AW et al. | Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha. | 2000 | J. Lipid Res. | pmid:11060349 |
| Ferdinandusse S et al. | Subcellular localization and physiological role of alpha-methylacyl-CoA racemase. | 2000 | J. Lipid Res. | pmid:11060359 |
| Ferdinandusse S et al. | Plasma analysis of di- and trihydroxycholestanoic acid diastereoisomers in peroxisomal alpha-methylacyl-CoA racemase deficiency. | 2001 | J. Lipid Res. | pmid:11160375 |
| Jansen GA et al. | Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11341778 |
| pmid:11356170 | ||||
| pmid:11356171 | ||||
| Van Veldhoven PP et al. | Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency. | 2001 | Eur. J. Clin. Invest. | pmid:11473573 |
| Verhoeven NM and Jakobs C | Human metabolism of phytanic acid and pristanic acid. | 2001 | Prog. Lipid Res. | pmid:11591435 |
| Hunt MC et al. | Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism. | 2002 | J. Biol. Chem. | pmid:11673457 |
| Ofman R et al. | Demonstration of dimethylnonanoyl-CoA thioesterase activity in rat liver peroxisomes followed by purification and molecular cloning of the thioesterase involved. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11785945 |
| McLean BN et al. | A new defect of peroxisomal function involving pristanic acid: a case report. | 2002 | J. Neurol. Neurosurg. Psychiatr. | pmid:11861706 |
| Ferdinandusse S et al. | Stereochemistry of the peroxisomal branched-chain fatty acid alpha- and beta-oxidation systems in patients suffering from different peroxisomal disorders. | 2002 | J. Lipid Res. | pmid:11893780 |
| Schluter A et al. | Phytanic acid, but not pristanic acid, mediates the positive effects of phytol derivatives on brown adipocyte differentiation. | 2002 | FEBS Lett. | pmid:12062414 |
| Idel S et al. | Branched chain fatty acids induce nitric oxide-dependent apoptosis in vascular smooth muscle cells. | 2002 | J. Biol. Chem. | pmid:12368296 |
| Gootjes J et al. | Biochemical markers predicting survival in peroxisome biogenesis disorders. | 2002 | Neurology | pmid:12473763 |
| Setchell KD et al. | Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy. | 2003 | Gastroenterology | pmid:12512044 |
| pmid:12814641 | ||||
| ten Brink HJ et al. | In vivo study of phytanic acid alpha-oxidation in classic Refsum's disease and chondrodysplasia punctata. | 1992 | Pediatr. Res. | pmid:1282700 |
| Straube R et al. | Membrane differential filtration is safe and effective for the long-term treatment of Refsum syndrome--an update of treatment modalities and pathophysiological cognition. | 2003 | Transfus. Apher. Sci. | pmid:12877898 |
| Mobley JA et al. | Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro. | 2003 | Cancer Epidemiol. Biomarkers Prev. | pmid:12917210 |
| ten Brink HJ et al. | Pristanic acid and phytanic acid in plasma from patients with peroxisomal disorders: stable isotope dilution analysis with electron capture negative ion mass fragmentography. | 1992 | J. Lipid Res. | pmid:1372637 |
| Chow CW et al. | Autopsy findings in two siblings with infantile Refsum disease. | 1992 | Acta Neuropathol. | pmid:1373019 |
| ten Brink HJ et al. | Phytanic acid alpha-oxidation: accumulation of 2-hydroxyphytanic acid and absence of 2-oxophytanic acid in plasma from patients with peroxisomal disorders. | 1992 | J. Lipid Res. | pmid:1385561 |
| Wanders RJ et al. | Activation and oxidation of pristanic acid in rat liver: identification of a distinct, clofibrate non-inducible pristanoyl-CoA oxidase. | 1992 | Prog. Clin. Biol. Res. | pmid:1438370 |
| Wanders RJ et al. | Molecular analysis of disorders of peroxisomal beta-oxidation. | 1992 | Prog. Clin. Biol. Res. | pmid:1438395 |
| Johnson DW et al. | Measurement of plasma pristanic, phytanic and very long chain fatty acids by liquid chromatography-electrospray tandem mass spectrometry for the diagnosis of peroxisomal disorders. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14630371 |
| Singh I et al. | Phytanic acid alpha-oxidation in human cultured skin fibroblasts. | 1992 | Biochim. Biophys. Acta | pmid:1463774 |
| Singh H et al. | Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblasts. | 1992 | J. Lipid Res. | pmid:1464743 |
| Gootjes J et al. | Biochemical markers predicting survival in peroxisome biogenesis disorders. | 2003 | Adv. Exp. Med. Biol. | pmid:14713214 |
| Zomer AW et al. | Phytanic and pristanic acid are naturally occuring ligands. | 2003 | Adv. Exp. Med. Biol. | pmid:14713238 |
| Atshaves BP et al. | Sexually dimorphic metabolism of branched-chain lipids in C57BL/6J mice. | 2004 | J. Lipid Res. | pmid:14993239 |
| Westin MA et al. | Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. | 2004 | J. Biol. Chem. | pmid:15007068 |
| van den Brink DM et al. | Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid. | 2004 | Mol. Genet. Metab. | pmid:15110319 |
| Peduto A et al. | Hyperpipecolic acidaemia: a diagnostic tool for peroxisomal disorders. | 2004 | Mol. Genet. Metab. | pmid:15234336 |
| Clarke CE et al. | Tremor and deep white matter changes in alpha-methylacyl-CoA racemase deficiency. | 2004 | Neurology | pmid:15249642 |
| pmid:15574183 | ||||
| pmid:15644212 | ||||
| Gloerich J et al. | A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARalpha-dependent and -independent pathways. | 2005 | J. Lipid Res. | pmid:15654129 |
| Atshaves BP et al. | Effect of branched-chain fatty acid on lipid dynamics in mice lacking liver fatty acid binding protein gene. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15692150 |
| Wanders RJ et al. | Characteristics and subcellular localization of pristanoyl-CoA synthetase in rat liver. | 1992 | Biochim. Biophys. Acta | pmid:1596515 |
| Roe DS et al. | Differentiation of long-chain fatty acid oxidation disorders using alternative precursors and acylcarnitine profiling in fibroblasts. | 2006 | Mol. Genet. Metab. | pmid:16297647 |
| Huyghe S et al. | Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice. | 2006 | Endocrinology | pmid:16484321 |
| Ferdinandusse S et al. | Mutations in the gene encoding peroxisomal sterol carrier protein X (SCPx) cause leukencephalopathy with dystonia and motor neuropathy. | 2006 | Am. J. Hum. Genet. | pmid:16685654 |
| pmid:16773508 | ||||
| Gloerich J et al. | Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation. | 2007 | J. Lipid Res. | pmid:17015885 |
| Atshaves BP et al. | Effect of SCP-x gene ablation on branched-chain fatty acid metabolism. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17068117 |