Pristanic acid

Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.

Cross Reference

Introduction

To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pristanic acid?

Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pristanic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Refsum Disease D012035 19 associated lipids
Cholestasis D002779 23 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Peroxisomal Disorders D018901 5 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Retinitis Pigmentosa D012174 6 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Dystonia D004421 3 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pristanic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pristanic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pristanic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pristanic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pristanic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Pristanic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pristanic acid

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Authors Title Published Journal PubMed Link
Leipnitz G et al. Pristanic acid promotes oxidative stress in brain cortex of young rats: a possible pathophysiological mechanism for brain damage in peroxisomal disorders. 2011 Brain Res. pmid:21241675
Mobley JA et al. Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro. 2003 Cancer Epidemiol. Biomarkers Prev. pmid:12917210
Wright ME et al. Serum phytanic and pristanic acid levels and prostate cancer risk in Finnish smokers. 2014 Cancer Med pmid:25132681
Harris HM et al. Phytanic acid, pristanic acid, and very-long-chain fatty acid methyl esters measured simultaneously by capillary gas chromatography. 1989 Clin. Chem. pmid:2702761
ten Brink HJ et al. Diagnosis of peroxisomal disorders by analysis of phytanic and pristanic acids in stored blood spots collected at neonatal screening. 1993 Clin. Chem. pmid:8375069
Poulos A et al. Defective oxidation of pristanic acid by fibroblasts from patients with disorders in propionic acid metabolism. 1990 Clin. Genet. pmid:2311265
Rizzo WB The role of fatty aldehyde dehydrogenase in epidermal structure and function. 2011 Dermatoendocrinol pmid:21695018
Huyghe S et al. Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice. 2006 Endocrinology pmid:16484321
Dahlgren J et al. Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study. 2007 Environ Health pmid:17316448
Van Veldhoven PP et al. Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency. 2001 Eur. J. Clin. Invest. pmid:11473573