MeSH term | MeSH ID | Detail |
---|---|---|
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Brain Damage, Chronic | D001925 | 6 associated lipids |
Peroxisomal Disorders | D018901 | 5 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.
To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Pristanic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Brain Damage, Chronic | D001925 | 6 associated lipids |
Peroxisomal Disorders | D018901 | 5 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Van Veldhoven PP et al. | Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency. | 2001 | Eur. J. Clin. Invest. | pmid:11473573 |
pmid:11356171 | ||||
pmid:11356170 | ||||
Jansen GA et al. | Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11341778 |
Ferdinandusse S et al. | Plasma analysis of di- and trihydroxycholestanoic acid diastereoisomers in peroxisomal alpha-methylacyl-CoA racemase deficiency. | 2001 | J. Lipid Res. | pmid:11160375 |
Ferdinandusse S et al. | Subcellular localization and physiological role of alpha-methylacyl-CoA racemase. | 2000 | J. Lipid Res. | pmid:11060359 |
Zomer AW et al. | Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha. | 2000 | J. Lipid Res. | pmid:11060349 |
Wanders RJ et al. | Lipid metabolism in peroxisomes: enzymology, functions and dysfunctions of the fatty acid alpha- and beta-oxidation systems in humans. | 2000 | Biochem. Soc. Trans. | pmid:10816116 |
Ferdinandusse S et al. | Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10486279 |
Steinberg SJ et al. | Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10198260 |