MeSH term | MeSH ID | Detail |
---|---|---|
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Brain Damage, Chronic | D001925 | 6 associated lipids |
Peroxisomal Disorders | D018901 | 5 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.
To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pristanic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Brain Damage, Chronic | D001925 | 6 associated lipids |
Peroxisomal Disorders | D018901 | 5 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schrader M and Fahimi HD | The peroxisome: still a mysterious organelle. | 2008 | Histochem. Cell Biol. | pmid:18274771 |
Al-Dirbashi OY et al. | Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders. | 2008 | J. Lipid Res. | pmid:18441019 |
pmid:18536048 | ||||
Zheng BS et al. | Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings. | 2008 | J. Exp. Bot. | pmid:18687588 |
Kase BF et al. | Separation of phytanic and pristanic acid by high-pressure liquid chromatography: application of the method. | 1991 | Anal. Biochem. | pmid:1888042 |
pmid:19005174 | ||||
Krause C et al. | Rational diagnostic strategy for Zellweger syndrome spectrum patients. | 2009 | Eur. J. Hum. Genet. | pmid:19142205 |
Mackie JT et al. | Phytol-induced hepatotoxicity in mice. | 2009 | Toxicol Pathol | pmid:19188468 |
Rönicke S et al. | The influence of the branched-chain fatty acids pristanic acid and Refsum disease-associated phytanic acid on mitochondrial functions and calcium regulation of hippocampal neurons, astrocytes, and oligodendrocytes. | 2009 | Neurobiol. Dis. | pmid:19703563 |
Guo XR et al. | The sterol carrier protein 2/3-oxoacyl-CoA thiolase (SCPx) is involved in cholesterol uptake in the midgut of Spodoptera litura: gene cloning, expression, localization and functional analyses. | 2009 | BMC Mol. Biol. | pmid:19912624 |