MeSH term | MeSH ID | Detail |
---|---|---|
Brain Damage, Chronic | D001925 | 6 associated lipids |
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Peroxisomal Disorders | D018901 | 5 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.
To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pristanic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Brain Damage, Chronic | D001925 | 6 associated lipids |
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Peroxisomal Disorders | D018901 | 5 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Leipnitz G et al. | Pristanic acid promotes oxidative stress in brain cortex of young rats: a possible pathophysiological mechanism for brain damage in peroxisomal disorders. | 2011 | Brain Res. | pmid:21241675 |
Sevin C et al. | Autosomal recessive cerebellar ataxia caused by mutations in the PEX2 gene. | 2011 | Orphanet J Rare Dis | pmid:21392394 |
Busanello EN et al. | Neurochemical evidence that pristanic acid impairs energy production and inhibits synaptic Na(+), K(+)-ATPase activity in brain of young rats. | 2011 | Neurochem. Res. | pmid:21445584 |
Kemp S et al. | Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance. | 2011 | Br. J. Pharmacol. | pmid:21488864 |
Kruska N and Reiser G | Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. | 2011 | Neurobiol. Dis. | pmid:21570468 |
Kou J et al. | Peroxisomal alterations in Alzheimer's disease. | 2011 | Acta Neuropathol. | pmid:21594711 |
Werner LB et al. | Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study. | 2011 | Lipids Health Dis | pmid:21663648 |
Wanders RJ et al. | Phytanic acid metabolism in health and disease. | 2011 | Biochim. Biophys. Acta | pmid:21683154 |
Thompson SA et al. | Relapsing encephalopathy in a patient with α-methylacyl-CoA racemase deficiency. | 2009 | BMJ Case Rep | pmid:21686617 |
Rizzo WB | The role of fatty aldehyde dehydrogenase in epidermal structure and function. | 2011 | Dermatoendocrinol | pmid:21695018 |