MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Zellweger Syndrome | D015211 | 39 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.
To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pristanic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Zellweger Syndrome | D015211 | 39 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Atshaves BP et al. | Sexually dimorphic metabolism of branched-chain lipids in C57BL/6J mice. | 2004 | J. Lipid Res. | pmid:14993239 |
Gloerich J et al. | A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARalpha-dependent and -independent pathways. | 2005 | J. Lipid Res. | pmid:15654129 |
Gloerich J et al. | Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation. | 2007 | J. Lipid Res. | pmid:17015885 |
Verhoeven NM et al. | Phytanic acid and pristanic acid are oxidized by sequential peroxisomal and mitochondrial reactions in cultured fibroblasts. | 1998 | J. Lipid Res. | pmid:9469587 |
Van Veldhoven PP | Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism. | 2010 | J. Lipid Res. | pmid:20558530 |
Al-Dirbashi OY et al. | Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders. | 2008 | J. Lipid Res. | pmid:18441019 |
Wanders RJ et al. | The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results. | 2010 | J. Inherit. Metab. Dis. | pmid:20490924 |
Sequeira JS et al. | Niemann-Pick disease type C and defective peroxisomal beta-oxidation of branched-chain substrates. | 1998 | J. Inherit. Metab. Dis. | pmid:9584266 |
Verhoeven NM et al. | The metabolism of phytanic acid and pristanic acid in man: a review. | 1998 | J. Inherit. Metab. Dis. | pmid:9819701 |
Verhoeven NM et al. | Studies on the oxidation of phytanic acid and pristanic acid in human fibroblasts by acylcarnitine analysis. | 1998 | J. Inherit. Metab. Dis. | pmid:9819705 |