MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Zellweger Syndrome | D015211 | 39 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.
To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Pristanic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Retinitis Pigmentosa | D012174 | 6 associated lipids |
Zellweger Syndrome | D015211 | 39 associated lipids |
Dystonia | D004421 | 3 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Verhoeven NM et al. | Pristanic acid beta-oxidation in peroxisomal disorders: studies in cultured human fibroblasts. | 1998 | Biochim. Biophys. Acta | pmid:9555092 |
Vreken P et al. | Rapid stable isotope dilution analysis of very-long-chain fatty acids, pristanic acid and phytanic acid using gas chromatography-electron impact mass spectrometry. | 1998 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9746242 |
Wanders RJ et al. | Identification of the newly discovered 58 kDa peroxisomal thiolase SCPx as the main thiolase involved in both pristanic acid and trihydroxycholestanoic acid oxidation: implications for peroxisomal beta-oxidation disorders. | 1998 | J. Inherit. Metab. Dis. | pmid:9686381 |
Dieuaide-Noubhani M et al. | Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal beta-oxidation of pristanic acid. | 1997 | Biochem. J. | pmid:9230115 |
van Grunsven EG et al. | Complementation analysis of fibroblasts from peroxisomal fatty acid oxidation deficient patients shows high frequency of bifunctional enzyme deficiency plus intragenic complementation: unequivocal evidence for differential defects in the same enzyme protein. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9196058 |
Mota CR et al. | Rhizomelic chondrodysplasia punctata-like phenotype in a newborn male with normal peroxisomal function. | 1997 | J Pediatr Orthop B | pmid:9039662 |
van Grunsven EG and Wanders RJ | Genetic heterogeneity in patients with a disorder of peroxisomal beta-oxidation: a complementation study based on pristanic acid beta-oxidation suggesting different enzyme defects. | 1997 | J. Inherit. Metab. Dis. | pmid:9266375 |
Verhoeven NM et al. | Formation of 2,3-pristenic acid and 3-hydroxypristanic acid from pristanic acid in human liver. | 1997 | J. Inherit. Metab. Dis. | pmid:9266376 |
Verhoeven NM et al. | Phytanic acid alpha-oxidation: decarboxylation of 2-hydroxyphytanoyl-CoA to pristanic acid in human liver. | 1997 | J. Lipid Res. | pmid:9374128 |
Verhoeven NM et al. | Resolution of the phytanic acid alpha-oxidation pathway: identification of pristanal as product of the decarboxylation of 2-hydroxyphytanoyl-CoA. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266824 |