| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Peroxisomal Disorders | D018901 | 5 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Chondrodysplasia Punctata | D002806 | 8 associated lipids |
Pristanic acid
Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.
Cross Reference
Introduction
To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pristanic acid?
Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Pristanic acid
PubChem Associated disorders and diseases
What pathways are associated with Pristanic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- J. Lipid Res. (3)
- J. Neurol. Neurosurg. Psychiatr. (1)
- Cancer Epidemiol. Biomarkers Prev. (1)
- Others (1)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pristanic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Pristanic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Pristanic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Pristanic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Pristanic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Pristanic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Atshaves BP et al. | Sexually dimorphic metabolism of branched-chain lipids in C57BL/6J mice. | 2004 | J. Lipid Res. | pmid:14993239 |
| Gloerich J et al. | A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARalpha-dependent and -independent pathways. | 2005 | J. Lipid Res. | pmid:15654129 |
| Gloerich J et al. | Metabolism of phytol to phytanic acid in the mouse, and the role of PPARalpha in its regulation. | 2007 | J. Lipid Res. | pmid:17015885 |
| Singh I et al. | Refsum disease: a defect in the alpha-oxidation of phytanic acid in peroxisomes. | 1993 | J. Lipid Res. | pmid:7504046 |
| Verhoeven NM et al. | Phytanic acid and pristanic acid are oxidized by sequential peroxisomal and mitochondrial reactions in cultured fibroblasts. | 1998 | J. Lipid Res. | pmid:9469587 |
| ten Brink HJ et al. | Phytanic acid alpha-oxidation: accumulation of 2-hydroxyphytanic acid and absence of 2-oxophytanic acid in plasma from patients with peroxisomal disorders. | 1992 | J. Lipid Res. | pmid:1385561 |
| Zomer AW et al. | Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha. | 2000 | J. Lipid Res. | pmid:11060349 |
| Ferdinandusse S et al. | Subcellular localization and physiological role of alpha-methylacyl-CoA racemase. | 2000 | J. Lipid Res. | pmid:11060359 |
| Verhoeven NM et al. | Analysis of pristanic acid beta-oxidation intermediates in plasma from healthy controls and patients affected with peroxisomal disorders by stable isotope dilution gas chromatography mass spectrometry. | 1999 | J. Lipid Res. | pmid:9925655 |
| Van Veldhoven PP | Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism. | 2010 | J. Lipid Res. | pmid:20558530 |
| Al-Dirbashi OY et al. | Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders. | 2008 | J. Lipid Res. | pmid:18441019 |
| McLean BN et al. | A new defect of peroxisomal function involving pristanic acid: a case report. | 2002 | J. Neurol. Neurosurg. Psychiatr. | pmid:11861706 |
| Thompson SA et al. | Relapsing encephalopathy in a patient with alpha-methylacyl-CoA racemase deficiency. | 2008 | J. Neurol. Neurosurg. Psychiatr. | pmid:18032455 |
| Busanello EN et al. | Experimental evidence that pristanic acid disrupts mitochondrial homeostasis in brain of young rats. | 2012 | J. Neurosci. Res. | pmid:22183871 |
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| Werner LB et al. | Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study. | 2011 | Lipids Health Dis | pmid:21663648 |
| Terre'Blanche G et al. | Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid--a case report. | 2011 | Lipids Health Dis | pmid:21871076 |
| van den Brink DM et al. | Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid. | 2004 | Mol. Genet. Metab. | pmid:15110319 |
| Peduto A et al. | Hyperpipecolic acidaemia: a diagnostic tool for peroxisomal disorders. | 2004 | Mol. Genet. Metab. | pmid:15234336 |
| Roe DS et al. | Differentiation of long-chain fatty acid oxidation disorders using alternative precursors and acylcarnitine profiling in fibroblasts. | 2006 | Mol. Genet. Metab. | pmid:16297647 |
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| Busanello EN et al. | Neurochemical evidence that pristanic acid impairs energy production and inhibits synaptic Na(+), K(+)-ATPase activity in brain of young rats. | 2011 | Neurochem. Res. | pmid:21445584 |
| Gootjes J et al. | Biochemical markers predicting survival in peroxisome biogenesis disorders. | 2002 | Neurology | pmid:12473763 |
| Clarke CE et al. | Tremor and deep white matter changes in alpha-methylacyl-CoA racemase deficiency. | 2004 | Neurology | pmid:15249642 |
| Kapina V et al. | Relapsing rhabdomyolysis due to peroxisomal alpha-methylacyl-coa racemase deficiency. | 2010 | Neurology | pmid:20921516 |
| Pyper SR et al. | PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. | 2010 | Nucl Recept Signal | pmid:20414453 |
| Klein CJ et al. | Plasma fatty acids in premature infants with hyperbilirubinemia: before-and-after nutrition support with fish oil emulsion. | 2013 | Nutr Clin Pract | pmid:23319354 |
| McMillan HJ et al. | Specific combination of compound heterozygous mutations in 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency. | 2012 | Orphanet J Rare Dis | pmid:23181892 |
| Sevin C et al. | Autosomal recessive cerebellar ataxia caused by mutations in the PEX2 gene. | 2011 | Orphanet J Rare Dis | pmid:21392394 |
| ten Brink HJ et al. | In vivo study of phytanic acid alpha-oxidation in classic Refsum's disease and chondrodysplasia punctata. | 1992 | Pediatr. Res. | pmid:1282700 |
| Astarita G et al. | Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. | 2010 | PLoS ONE | pmid:20838618 |
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| Wanders RJ et al. | Activation and oxidation of pristanic acid in rat liver: identification of a distinct, clofibrate non-inducible pristanoyl-CoA oxidase. | 1992 | Prog. Clin. Biol. Res. | pmid:1438370 |
| Wanders RJ et al. | Molecular analysis of disorders of peroxisomal beta-oxidation. | 1992 | Prog. Clin. Biol. Res. | pmid:1438395 |
| Verhoeven NM and Jakobs C | Human metabolism of phytanic acid and pristanic acid. | 2001 | Prog. Lipid Res. | pmid:11591435 |
| Kase BF and Björkhem I | Studies on the degradation of [U-3H]-phytanic acid and [U-3H]-pristanic acid in cultured fibroblasts from children with peroxisomal disorders. | 1996 | Scand. J. Clin. Lab. Invest. | pmid:8761525 |
| Mackie JT et al. | Phytol-induced hepatotoxicity in mice. | 2009 | Toxicol Pathol | pmid:19188468 |
| Straube R et al. | Membrane differential filtration is safe and effective for the long-term treatment of Refsum syndrome--an update of treatment modalities and pathophysiological cognition. | 2003 | Transfus. Apher. Sci. | pmid:12877898 |
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