Pristanic acid

Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.

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Introduction

To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pristanic acid?

Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pristanic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Refsum Disease D012035 19 associated lipids
Cholestasis D002779 23 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Peroxisomal Disorders D018901 5 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Chondrodysplasia Punctata D002806 8 associated lipids
Per page 10 20 | Total 14

PubChem Associated disorders and diseases

What pathways are associated with Pristanic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pristanic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pristanic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pristanic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pristanic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Pristanic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pristanic acid

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Authors Title Published Journal PubMed Link
Wanders RJ et al. Clinical and biochemical characteristics of peroxisomal disorders: an update. 1994 Eur. J. Pediatr. pmid:7957386
ten Brink HJ et al. Heterogeneity in di/trihydroxycholestanoic acidaemia. 1994 Ann. Clin. Biochem. pmid:8060102
Singh H et al. Peroxisomal beta-oxidation of branched chain fatty acids in rat liver. Evidence that carnitine palmitoyltransferase I prevents transport of branched chain fatty acids into mitochondria. 1994 J. Biol. Chem. pmid:8144536
Pahan K et al. Phytanic acid alpha-oxidation in rat liver mitochondria. 1994 Biochim. Biophys. Acta pmid:7803482
ten Brink HJ et al. Diagnosis of peroxisomal disorders by analysis of phytanic and pristanic acids in stored blood spots collected at neonatal screening. 1993 Clin. Chem. pmid:8375069
Schmitt K et al. [Zellweger syndrome, neonatal adrenoleukodystrophy or infantile Refsum's disease in a case with generalized peroxisome defect?]. 1993 Wien. Klin. Wochenschr. pmid:7687405
Singh I et al. Refsum disease: a defect in the alpha-oxidation of phytanic acid in peroxisomes. 1993 J. Lipid Res. pmid:7504046
Wanders RJ et al. Characteristics and subcellular localization of pristanoyl-CoA synthetase in rat liver. 1992 Biochim. Biophys. Acta pmid:1596515
ten Brink HJ et al. Pristanic acid and phytanic acid in plasma from patients with peroxisomal disorders: stable isotope dilution analysis with electron capture negative ion mass fragmentography. 1992 J. Lipid Res. pmid:1372637
Chow CW et al. Autopsy findings in two siblings with infantile Refsum disease. 1992 Acta Neuropathol. pmid:1373019
ten Brink HJ et al. In vivo study of phytanic acid alpha-oxidation in classic Refsum's disease and chondrodysplasia punctata. 1992 Pediatr. Res. pmid:1282700
Singh I et al. Phytanic acid alpha-oxidation in human cultured skin fibroblasts. 1992 Biochim. Biophys. Acta pmid:1463774
Wanders RJ et al. Activation and oxidation of pristanic acid in rat liver: identification of a distinct, clofibrate non-inducible pristanoyl-CoA oxidase. 1992 Prog. Clin. Biol. Res. pmid:1438370
Wanders RJ et al. Molecular analysis of disorders of peroxisomal beta-oxidation. 1992 Prog. Clin. Biol. Res. pmid:1438395
Singh H et al. Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblasts. 1992 J. Lipid Res. pmid:1464743
ten Brink HJ et al. Phytanic acid alpha-oxidation: accumulation of 2-hydroxyphytanic acid and absence of 2-oxophytanic acid in plasma from patients with peroxisomal disorders. 1992 J. Lipid Res. pmid:1385561
ten Brink HJ et al. Pristanic acid does not accumulate in peroxisomal acyl-CoA oxidase deficiency: evidence for a distinct peroxisomal pristanyl-CoA oxidase. 1991 J. Inherit. Metab. Dis. pmid:1779614
Kase BF et al. Separation of phytanic and pristanic acid by high-pressure liquid chromatography: application of the method. 1991 Anal. Biochem. pmid:1888042
ten Brink HJ et al. Pristanic acid and phytanic acid in plasma from patients with a single peroxisomal enzyme deficiency. 1991 J. Inherit. Metab. Dis. pmid:1722861
Poulos A et al. Defective oxidation of pristanic acid by fibroblasts from patients with disorders in propionic acid metabolism. 1990 Clin. Genet. pmid:2311265
Harris HM et al. Phytanic acid, pristanic acid, and very-long-chain fatty acid methyl esters measured simultaneously by capillary gas chromatography. 1989 Clin. Chem. pmid:2702761
Poulos A et al. Accumulation of pristanic acid (2, 6, 10, 14 tetramethylpentadecanoic acid) in the plasma of patients with generalised peroxisomal dysfunction. 1988 Eur. J. Pediatr. pmid:2452737
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