| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Peroxisomal Disorders | D018901 | 5 associated lipids |
| Brain Damage, Chronic | D001925 | 6 associated lipids |
| Chondrodysplasia Punctata | D002806 | 8 associated lipids |
Pristanic acid
Pristanic acid is a lipid of Prenol Lipids (PR) class. Pristanic acid is associated with abnormalities such as Refsum Disease, Peroxisomal Disorders, Hereditary Diseases, Peripheral Neuropathy and Sensory neuropathy. The involved functions are known as physiological aspects, Regulation, Pathogenesis, Oxidation and Peroxisome Proliferator-activated Receptor Activity [MoA]. Pristanic acid often locates in peroxisome, Body tissue, Mitochondria, Membrane of peroxisome and Organelles. The associated genes with Pristanic acid are PSG5 gene, LGALS4 gene, PEX2 gene, ACSL4 gene and ACSL1 Gene. The related lipids are pristanic acid, Fatty Acids, branched chain fatty acid, Plasmalogens and 3-hydroxypristanic acid.
Cross Reference
Introduction
To understand associated biological information of Pristanic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Pristanic acid?
Pristanic acid is suspected in Peroxisomal Disorders, Refsum Disease, Protein Deficiency, Retinitis Pigmentosa, Enzyme Deficiency, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Pristanic acid
PubChem Associated disorders and diseases
What pathways are associated with Pristanic acid
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pristanic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
- J. Lipid Res. (3)
- J. Neurol. Neurosurg. Psychiatr. (1)
- Cancer Epidemiol. Biomarkers Prev. (1)
- Others (1)
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Pristanic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Pristanic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Pristanic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Pristanic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Pristanic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Pristanic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chow CW et al. | Autopsy findings in two siblings with infantile Refsum disease. | 1992 | Acta Neuropathol. | pmid:1373019 |
| Gootjes J et al. | Biochemical markers predicting survival in peroxisome biogenesis disorders. | 2003 | Adv. Exp. Med. Biol. | pmid:14713214 |
| Zomer AW et al. | Phytanic and pristanic acid are naturally occuring ligands. | 2003 | Adv. Exp. Med. Biol. | pmid:14713238 |
| van Grunsven EG et al. | Peroxisomal bifunctional protein deficiency revisited: resolution of its true enzymatic and molecular basis. | 1999 | Am. J. Hum. Genet. | pmid:9915948 |
| Ferdinandusse S et al. | Mutations in the gene encoding peroxisomal sterol carrier protein X (SCPx) cause leukencephalopathy with dystonia and motor neuropathy. | 2006 | Am. J. Hum. Genet. | pmid:16685654 |
| Atshaves BP et al. | Effect of SCP-x gene ablation on branched-chain fatty acid metabolism. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17068117 |
| Atshaves BP et al. | Effect of branched-chain fatty acid on lipid dynamics in mice lacking liver fatty acid binding protein gene. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15692150 |
| Kase BF et al. | Separation of phytanic and pristanic acid by high-pressure liquid chromatography: application of the method. | 1991 | Anal. Biochem. | pmid:1888042 |
| ten Brink HJ et al. | Heterogeneity in di/trihydroxycholestanoic acidaemia. | 1994 | Ann. Clin. Biochem. | pmid:8060102 |
| Paton BC et al. | Biochemical findings in a series of Australian patients with isolated defects in peroxisomal beta-oxidation. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993614 |
| Steinberg SJ et al. | Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10198260 |
| Jakobs BS and Wanders RJ | Fatty acid beta-oxidation in peroxisomes and mitochondria: the first, unequivocal evidence for the involvement of carnitine in shuttling propionyl-CoA from peroxisomes to mitochondria. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7654220 |
| van Grunsven EG et al. | Complementation analysis of fibroblasts from peroxisomal fatty acid oxidation deficient patients shows high frequency of bifunctional enzyme deficiency plus intragenic complementation: unequivocal evidence for differential defects in the same enzyme protein. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9196058 |
| Ferdinandusse S et al. | Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10486279 |
| Ofman R et al. | Demonstration of dimethylnonanoyl-CoA thioesterase activity in rat liver peroxisomes followed by purification and molecular cloning of the thioesterase involved. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11785945 |
| Verhoeven NM et al. | Resolution of the phytanic acid alpha-oxidation pathway: identification of pristanal as product of the decarboxylation of 2-hydroxyphytanoyl-CoA. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266824 |
| Jansen GA et al. | Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11341778 |
| Dieuaide-Noubhani M et al. | Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal beta-oxidation of pristanic acid. | 1997 | Biochem. J. | pmid:9230115 |
| Wanders RJ et al. | Lipid metabolism in peroxisomes: enzymology, functions and dysfunctions of the fatty acid alpha- and beta-oxidation systems in humans. | 2000 | Biochem. Soc. Trans. | pmid:10816116 |
| Singh I et al. | Phytanic acid alpha-oxidation in human cultured skin fibroblasts. | 1992 | Biochim. Biophys. Acta | pmid:1463774 |