forskolin

Forskolin is a lipid of Prenol Lipids (PR) class. Forskolin is associated with abnormalities such as Cholestasis, Vocal cord dysfunction familial, Hypothyroidism, Renal tubular disorder and Disintegration (morphologic abnormality). The involved functions are known as Cell Proliferation, Anabolism, mRNA Expression, Agent and Signal. Forskolin often locates in Extracellular, Body tissue, Skin, Tissue membrane and Membrane. The associated genes with forskolin are P4HTM gene, SLC33A1 gene, NR1I2 gene, Genes, Reporter and CYP3A gene. The related lipids are Steroids, steroid sulfate, Fatty Acids, LYSO-PC and Lipopolysaccharides.

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Introduction

To understand associated biological information of forskolin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with forskolin?

forskolin is suspected in Cyst, Kozlowski Celermajer Tink syndrome, Vocal cord dysfunction familial, Alzheimer's Disease, Cholestasis, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with forskolin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with forskolin

Lipid pathways are not clear in current pathway databases. We organized associated pathways with forskolin through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with forskolin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with forskolin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with forskolin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with forskolin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with forskolin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with forskolin

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Authors Title Published Journal PubMed Link
Cao HH et al. [Polymethoxylated flavonoids activate cystic fibrosis transmembrane conductance regulator chloride channel]. 2015 Sheng Li Xue Bao pmid:25896054
Kawabata H et al. A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. 2015 Exp. Hematol. pmid:25633564
Kusama K et al. Regulatory Action of Calcium Ion on Cyclic AMP-Enhanced Expression of Implantation-Related Factors in Human Endometrial Cells. 2015 PLoS ONE pmid:26161798
Covington JD et al. Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males. 2015 J. Clin. Endocrinol. Metab. pmid:26171795
Yukiura H et al. LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells. 2015 J. Cell. Sci. pmid:26345369
Jóźwiak-Bębenista M et al. The cyclic AMP effects and neuroprotective activities of PACAP and VIP in cultured astrocytes and neurons exposed to oxygen-glucose deprivation. 2015 Pharmacol Rep pmid:25712659
Tao H et al. Cyclic AMP prevents decrease of phosphorylated ezrin/radixin/moesin and chloride intracellular channel 5 expressions in injured podocytes. 2015 Clin. Exp. Nephrol. pmid:25725994
Angel-Chavez LI et al. Forskolin suppresses delayed-rectifier K+ currents and enhances spike frequency-dependent adaptation of sympathetic neurons. 2015 PLoS ONE pmid:25962132
Fuccelli R et al. The hydroxytyrosol-dependent increase of TNF-α in LPS-activated human monocytes is mediated by PGE2 and adenylate cyclase activation. 2015 Toxicol In Vitro pmid:25866079
Mohan S et al. Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. 2015 Neurotoxicology pmid:25451967
Shrestha K et al. Regulation of ovulatory genes in bovine granulosa cells: lessons from siRNA silencing of PTGS2. 2015 Reproduction pmid:25323036
Pavan B et al. Quercetin and quercetin-3-O-glucoside interact with different components of the cAMP signaling cascade in human retinal pigment epithelial cells. 2015 Life Sci. pmid:25476834
Jansen SR et al. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. 2015 J. Cell. Mol. Med. pmid:25266063
Oztekin CV et al. Analysis of pomegranate juice components in rat corpora cavernosal relaxation. 2014 Mar-Apr Int. J. Impot. Res. pmid:23903908
Isensee J et al. Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. 2014 J. Cell. Sci. pmid:24190886
Pateraki I et al. Manoyl oxide (13R), the biosynthetic precursor of forskolin, is synthesized in specialized root cork cells in Coleus forskohlii. 2014 Plant Physiol. pmid:24481136
Cazabat L et al. Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters. 2014 Hum. Mol. Genet. pmid:24122441
Yasuo S et al. 2-Arachidonoyl glycerol sensitizes the pars distalis and enhances forskolin-stimulated prolactin secretion in Syrian hamsters. 2014 Chronobiol. Int. pmid:24200164
Hirabayashi M et al. Effect of leukemia inhibitory factor and forskolin on establishment of rat embryonic stem cell lines. 2014 J. Reprod. Dev. pmid:24317016
Sun H et al. Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl⁻ secretion: useful tools as regulators of Cl⁻ secretion. 2014 Biomed Res Int pmid:24818160