forskolin

Forskolin is a lipid of Prenol Lipids (PR) class. Forskolin is associated with abnormalities such as Cholestasis, Vocal cord dysfunction familial, Hypothyroidism, Renal tubular disorder and Disintegration (morphologic abnormality). The involved functions are known as Cell Proliferation, Anabolism, mRNA Expression, Agent and Signal. Forskolin often locates in Extracellular, Body tissue, Skin, Tissue membrane and Membrane. The associated genes with forskolin are P4HTM gene, SLC33A1 gene, NR1I2 gene, Genes, Reporter and CYP3A gene. The related lipids are Steroids, steroid sulfate, Fatty Acids, LYSO-PC and Lipopolysaccharides.

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Introduction

To understand associated biological information of forskolin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with forskolin?

forskolin is suspected in Cyst, Kozlowski Celermajer Tink syndrome, Vocal cord dysfunction familial, Alzheimer's Disease, Cholestasis, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with forskolin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with forskolin

Lipid pathways are not clear in current pathway databases. We organized associated pathways with forskolin through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with forskolin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with forskolin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with forskolin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with forskolin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with forskolin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with forskolin

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Authors Title Published Journal PubMed Link
Koutsogiannaki S et al. Oxidative stress parameters induced by exposure to either cadmium or 17β-estradiol on Mytilus galloprovincialis hemocytes. The role of signaling molecules. 2014 Aquat. Toxicol. pmid:24316436
Hirabayashi M et al. Derivation of embryonic stem cell lines from parthenogenetically developing rat blastocysts. 2014 Stem Cells Dev. pmid:24010570
Paldino E et al. Induction of dopaminergic neurons from human Wharton's jelly mesenchymal stem cell by forskolin. 2014 J. Cell. Physiol. pmid:23893793
Rojas-Charry L et al. Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. 2014 Neurotoxicology pmid:24792327
Ikari A et al. Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells. 2014 Biochim. Biophys. Acta pmid:24907662
Razmi A et al. Cyclic AMP pathway modifies memory through neural cell adhesion molecule alterations in the rat hippocampus. 2014 Acta Med Iran pmid:24901853
Cristóbal I et al. Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation. 2014 Biochim. Biophys. Acta pmid:24997451
Boinot C et al. Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing. 2014 J. Pharmacol. Exp. Ther. pmid:24970923
Mori M et al. Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation. 2014 Theriogenology pmid:24411494
Nwachukwu JC et al. Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. 2014 Elife pmid:24771768
Shirasu M et al. Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors. 2014 Neuron pmid:24361078
Mardones P et al. Cyclic AMP and alkaline pH downregulate carbonic anhydrase 2 in mouse fibroblasts. 2014 Biochim. Biophys. Acta pmid:24361611
Aflaki M et al. Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts. 2014 Circ. Res. pmid:24508724
DiRaddo JO et al. A real-time method for measuring cAMP production modulated by Gαi/o-coupled metabotropic glutamate receptors. 2014 J. Pharmacol. Exp. Ther. pmid:24659805
Marlar S et al. Elevated cAMP increases aquaporin-3 plasma membrane diffusion. 2014 Am. J. Physiol., Cell Physiol. pmid:24452376
Vardjan N et al. Dynamics of β-adrenergic/cAMP signaling and morphological changes in cultured astrocytes. 2014 Glia pmid:24464905
Luckie DB et al. Chemical rescue of ΔF508-CFTR in C127 epithelial cells reverses aberrant extracellular pH acidification to wild-type alkalization as monitored by microphysiometry. 2014 Biochem. Biophys. Res. Commun. pmid:25130467
Sahmi F et al. Factors regulating the bovine, caprine, rat and human ovarian aromatase promoters in a bovine granulosa cell model. 2014 Gen. Comp. Endocrinol. pmid:24556528
Cheng X et al. Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. 2014 Toxicol. Appl. Pharmacol. pmid:24747804
Li X et al. cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion. 2014 PLoS ONE pmid:24642777