Abietic acid is a lipid of Prenol Lipids (PR) class. Abietic acid is associated with abnormalities such as Hand eczema, Dermatitis, Vitelliform dystrophy, Wiskott-Aldrich Syndrome and Dehydration. The involved functions are known as Process, Oxidation, Anabolism, Transmembrane Transport and physiological aspects. Abietic acid often locates in Membrane, Protoplasm, Microsomes and Cellular Membrane. The associated genes with Abietic acid are SLC33A1 gene and ABCG2 gene. The related lipids are Pinene.
To understand associated biological information of Abietic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Abietic acid is suspected in Hand eczema, Dermatitis, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Abietic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ulcer | D014456 | 16 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Edema | D004487 | 152 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:28423677 | ||||
| pmid:28389357 | ||||
| pmid:22594762 | ||||
| pmid:22426093 | ||||
| pmid:22274948 | ||||
| pmid:22020363 | ||||
| pmid:22008013 | ||||
| pmid:21146981 | ||||
| pmid:20583317 | ||||
| pmid:19101885 | ||||
| pmid:17577378 | ||||
| pmid:17352501 | ||||
| pmid:16643007 | ||||
| pmid:14654249 | ||||
| pmid:12481865 | ||||
| pmid:12000325 | ||||
| pmid:11260236 | ||||
| pmid:27793449 | ||||
| pmid:27318791 | ||||
| pmid:26864272 | ||||
| pmid:26621449 | ||||
| pmid:26164238 | ||||
| pmid:25939920 | ||||
| pmid:25686209 | ||||
| pmid:25496486 | ||||
| pmid:25462275 | ||||
| pmid:25456583 | ||||
| pmid:25200370 | ||||
| pmid:25104764 | ||||
| pmid:24906785 | ||||
| pmid:24735394 | ||||
| pmid:13228858 | ||||
| pmid:26795242 | ||||
| pmid:16904803 | ||||
| pmid:18666177 | ||||
| pmid:14753721 | ||||
| pmid: | ||||
| Rao XP | N-Morpholino-Δ-dihydro-abietamide. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588936 |
| Wang K et al. | Methyl 7-oxo-12-propyl-amino-13-nitro-deisopropyl-dehydro-abietate. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21587581 |
| Zhang M et al. | 13-Ethoxy-carbonyl-16-(1-methyl-ethyl)-17,19-dinoratis-15-ene-4,14-dicarboxylic acid monohydrate: a new derivative of maleopimaric acid. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21583637 |
| Zhang M et al. | Maleopimaric acid acetic acid solvate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21582965 |
| Karlberg AT | Contact allergy to colophony. Chemical identifications of allergens, sensitization experiments and clinical experiences. | 1988 | Acta Derm Venereol Suppl (Stockh) | pmid:3188806 |
| Demers PA et al. | Exposure to dust, resin acids, and monoterpenes in softwood lumber mills. | 2000 Jul-Aug | AIHAJ | pmid:10976682 |
| Smith PA et al. | Detection of resin acid compounds in airborne particulate generated from rosin used as a soldering flux. | 1997 | Am Ind Hyg Assoc J | pmid:9425647 |
| Smith PA et al. | Oxidized resin acids in aerosol derived from rosin core solder. | 1998 | Am Ind Hyg Assoc J | pmid:9866169 |
| Frank P et al. | Ancient wood of the Acqualadrone rostrum: materials history through gas chromatography/mass spectrometry and sulfur X-ray absorption spectroscopy. | 2012 | Anal. Chem. | pmid:22545724 |
| Rafferty RJ et al. | Synthesis of complex and diverse compounds through ring distortion of abietic acid. | 2014 | Angew. Chem. Int. Ed. Engl. | pmid:24273016 |
| Suhng EA et al. | A Case of Allergic Contact Dermatitis Due to DuoDERM Extrathin®. | 2011 | Ann Dermatol | pmid:22346285 |
| Fransman W et al. | Respiratory symptoms and occupational exposures in New Zealand plywood mill workers. | 2003 | Ann Occup Hyg | pmid:12765869 |
| Eriksson K et al. | Dermal exposure to terpenic resin acids in Swedish carpentry workshops and sawmills. | 2004 | Ann Occup Hyg | pmid:15059803 |
| Johansson A et al. | Antimicrobial screening of zinc in the absence or presence of oleoresins and various resin acids. | 1995 | APMIS | pmid:7546644 |
| Patel GB et al. | Inhibition of pure cultures of methanogens by benzene ring compounds. | 1991 | Appl. Environ. Microbiol. | pmid:1746956 |
| Janocha S and Bernhardt R | Design and characterization of an efficient CYP105A1-based whole-cell biocatalyst for the conversion of resin acid diterpenoids in permeabilized Escherichia coli. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23793341 |
| Funk C and Croteau R | Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. | 1994 | Arch. Biochem. Biophys. | pmid:8311462 |
| LaFever RE et al. | Diterpenoid resin acid biosynthesis in conifers: enzymatic cyclization of geranylgeranyl pyrophosphate to abietadiene, the precursor of abietic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8053674 |
| Jung MJ et al. | A new abietic acid-type diterpene glucoside from the needles of Pinus densiflora. | 2009 | Arch. Pharm. Res. | pmid:20162397 |
| Nicholson RA | The actions of abietic acid in mammalian synaptosomal preparations. | 1994 | Biochem. Soc. Trans. | pmid:7958288 |
| Aranda FJ and VillalaÃn J | The interaction of abietic acid with phospholipid membranes. | 1997 | Biochim. Biophys. Acta | pmid:9271259 |
| VillalaÃn J | Location of the toxic molecule abietic acid in model membranes by MAS-NMR. | 1997 | Biochim. Biophys. Acta | pmid:9315624 |
| Jagalski V et al. | Biophysical study of resin acid effects on phospholipid membrane structure and properties. | 2016 | Biochim. Biophys. Acta | pmid:27544924 |
| Matsuya Y and Matsuya S | Effect of abietic acid and poly(methyl methacrylate) on the dissolution process of zinc oxide-eugenol cement. | 1994 | Biomaterials | pmid:8031992 |
| Kazakova OB et al. | [Synthesis, structure and farmacologycal activity of (7R,8S)-epoxy-(13R,17R)-trioxolaneabietic acid]. | 2013 Mar-Apr | Bioorg. Khim. | pmid:23964524 |
| Gigante B et al. | Catechols from abietic acid synthesis and evaluation as bioactive compounds. | 2003 | Bioorg. Med. Chem. | pmid:12659748 |
| Yang XW et al. | Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. | 2010 | Bioorg. Med. Chem. | pmid:20022253 |
| Talevi A et al. | Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17234417 |
| Yao F et al. | Preparation and application of abietic acid-derived optically active helical polymers and their chiral hydrogels. | 2013 | Bioresour. Technol. | pmid:23232223 |
| Mitsukura K et al. | Regio- and stereo-selective hydroxylation of abietic acid derivatives by Mucor circinelloides and Mortierella isabellina. | 2005 | Biotechnol. Lett. | pmid:16215830 |
| Clement YN et al. | Medicinal herb use among asthmatic patients attending a specialty care facility in Trinidad. | 2005 | BMC Complement Altern Med | pmid:15713232 |
| Gambichler T et al. | Contact dermatitis and other skin conditions in instrumental musicians. | 2004 | BMC Dermatol. | pmid:15090069 |
| Abbott E et al. | Laser microdissection of conifer stem tissues: isolation and analysis of high quality RNA, terpene synthase enzyme activity and terpenoid metabolites from resin ducts and cambial zone tissue of white spruce (Picea glauca). | 2010 | BMC Plant Biol. | pmid:20540781 |
| Karlberg AT and Lidén C | Colophony (rosin) in newspapers may contribute to hand eczema. | 1992 | Br. J. Dermatol. | pmid:1536781 |
| Sadhra S et al. | Identification of contact allergens in unmodified rosin using a combination of patch testing and analytical chemistry techniques. | 1996 | Br. J. Dermatol. | pmid:8733367 |
| Sousa Neto MD et al. | The influence of different grades of rosins and hydrogenated resins on the powder-liquid ratio of Grossman cements. | 1998 | Braz Dent J | pmid:9835799 |
| Fâhraeus-Van Ree GE and Payne JF | Enzyme cytochemical responses of mussels (Mytilus edulis) to resin acid constituents of pulp mill effluents. | 1999 | Bull Environ Contam Toxicol | pmid:10501718 |
| Belmonte M et al. | Effect of aerobic sludge with increasing level of adaptation on abietic acid biodegradation. | 2006 | Bull Environ Contam Toxicol | pmid:17219306 |
| Morgan CA and Wyndham RC | Characterization of tdt genes for the degradation of tricyclic diterpenes by Pseudomonas diterpeniphila A19-6a. | 2002 | Can. J. Microbiol. | pmid:11888163 |
| Shpatov AV et al. | Lipophilic extracts from needles and defoliated twigs of Pinus pumila from two different populations. | 2013 | Chem. Biodivers. | pmid:23418167 |
| Fujita Y et al. | New hypocholesterolemic abietamide derivatives. I. Structure-activity relationship. | 1980 | Chem. Pharm. Bull. | pmid:7389019 |
| Frija LM et al. | Isolation, chemical, and biotransformation routes of labdane-type diterpenes. | 2011 | Chem. Rev. | pmid:21618966 |
| Janocha S et al. | Resin acid conversion with CYP105A1: an enzyme with potential for the production of pharmaceutically relevant diterpenoids. | 2013 | Chembiochem | pmid:23371760 |
| Bleif S et al. | Identification of CYP106A2 as a regioselective allylic bacterial diterpene hydroxylase. | 2011 | Chembiochem | pmid:21271628 |
| Di Paolo RE et al. | Picosecond structural relaxation of abietic acid based amine end capped para-phenylenevinylene trimers in solution. | 2008 | Chemphyschem | pmid:18830995 |
| Burge PS et al. | Bronchial provocation studies in workers exposed to the fumes of electronic soldering fluxes. | 1980 | Clin. Allergy | pmid:7389068 |
| Boskabady MH et al. | Work-related respiratory symptoms and pulmonary function tests in northeast iranian (the city of Mashhad) carpenters. | 2010 | Clinics (Sao Paulo) | pmid:21120301 |
| Hausen BM et al. | Contact allergy due to colophony (VII). Sensitizing studies with oxidation products of abietic and related acids. | 1990 | Contact Derm. | pmid:2096024 |
| Ehrin E and Karlberg AT | Detection of rosin (colophony) components in technical products using an HPLC technique. | 1990 | Contact Derm. | pmid:2096025 |
| Karlberg AT | Pure abietic acid is not allergenic. | 1989 | Contact Derm. | pmid:2598660 |
| Karlberg AT et al. | Hydrogenation reduces the allergenicity of colophony (rosin). | 1988 | Contact Derm. | pmid:3180766 |
| Nakamura T | Contact dermatitis to Japanese black pine. | 1986 | Contact Derm. | pmid:3743045 |
| Karlberg AT et al. | Is abietic acid the allergenic component of colophony? | 1985 | Contact Derm. | pmid:4085221 |
| Koh D et al. | Colophony in bindi adhesive. | 1995 | Contact Derm. | pmid:7774206 |
| Hausen BM et al. | Contact allergy due to colophony. (IX). Sensitization studies with further products isolated after oxidative degradation of resin acids and colophony. | 1993 | Contact Derm. | pmid:8112061 |
| Shao LP et al. | The allergenicity of glycerol esters and other esters of rosin (colophony). | 1993 | Contact Derm. | pmid:8508634 |
| Karlberg AT and Magnusson K | Rosin components identified in diapers. | 1996 | Contact Derm. | pmid:8833460 |
| Gäfvert E and Färm G | Rosin (colophony) and zinc oxide in adhesive bandages. An appropriate combination for rosin-sensitive patients? | 1995 | Contact Derm. | pmid:8706397 |
| el Sayed F et al. | Contact urticaria from abietic acid. | 1995 | Contact Derm. | pmid:7554886 |
| Bergh M et al. | Colophony in paper-based surgical clothing. | 1994 | Contact Derm. | pmid:7867341 |
| Fisher AA | Paper dermatitis. | 1983 | Cutis | pmid:6406159 |
| Fisher AA | Allergic contact dermatitis in a violinist. The role of abietic acid--a sensitizer in rosin (colophony)--as the causative agent. | 1981 | Cutis | pmid:7016461 |
| Foussereau J et al. | [Allergologic studies of intolerance to rosin]. | 1980 | Derm Beruf Umwelt | pmid:7408638 |