Abietic acid is a lipid of Prenol Lipids (PR) class. Abietic acid is associated with abnormalities such as Hand eczema, Dermatitis, Vitelliform dystrophy, Wiskott-Aldrich Syndrome and Dehydration. The involved functions are known as Process, Oxidation, Anabolism, Transmembrane Transport and physiological aspects. Abietic acid often locates in Membrane, Protoplasm, Microsomes and Cellular Membrane. The associated genes with Abietic acid are SLC33A1 gene and ABCG2 gene. The related lipids are Pinene.
To understand associated biological information of Abietic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Abietic acid is suspected in Hand eczema, Dermatitis, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Abietic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ulcer | D014456 | 16 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Edema | D004487 | 152 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Sakamoto K et al. | Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16195419 |
| Karlberg AT et al. | Identification of 15-hydroperoxyabietic acid as a contact allergen in Portuguese colophony. | 1988 | J. Pharm. Pharmacol. | pmid:2896772 |
| Fernández MA et al. | Anti-inflammatory activity of abietic acid, a diterpene isolated from Pimenta racemosa var. grissea. | 2001 | J. Pharm. Pharmacol. | pmid:11428663 |
| Arnó M et al. | Synthesis of C-17-functionalized spongiane diterpenes: diastereoselective synthesis of (-)-spongian-16-oxo-17-al, (-)-acetyldendrillol-1, and (-)-aplyroseol-14. | 2003 | J. Org. Chem. | pmid:12585861 |
| Esteves MA et al. | Synthetic derivatives of abietic acid with radical scavenging activity. | 2001 | J. Nat. Prod. | pmid:11421739 |
| Prinz S et al. | Oxidation products of abietic acid and its methyl ester. | 2002 | J. Nat. Prod. | pmid:12444672 |
| Belmonte M et al. | Improved aerobic biodegradation of abietic acid in ECF bleached kraft mill effluent due to biomass adaptation. | 2006 | J. Hazard. Mater. | pmid:16386835 |
| Seal AN et al. | Identification and quantitation of compounds in a series of allelopathic and non-allelopathic rice root exudates. | 2004 | J. Chem. Ecol. | pmid:15537165 |
| Seal AN et al. | Evaluation of putative allelochemicals in rice root exudates for their role in the suppression of arrowhead root growth. | 2004 | J. Chem. Ecol. | pmid:15537166 |
| Vogel BS et al. | Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis. | 1996 | J. Biol. Chem. | pmid:8798524 |
| Smith DJ et al. | A large gene cluster in Burkholderia xenovorans encoding abietane diterpenoid catabolism. | 2007 | J. Bacteriol. | pmid:17586638 |
| Smith DJ et al. | Distinct roles for two CYP226 family cytochromes P450 in abietane diterpenoid catabolism by Burkholderia xenovorans LB400. | 2008 | J. Bacteriol. | pmid:18156276 |
| Siebert MR et al. | The need for enzymatic steering in abietic acid biosynthesis: gas-phase chemical dynamics simulations of carbocation rearrangements on a bifurcating potential energy surface. | 2011 | J. Am. Chem. Soc. | pmid:21548620 |
| Karlberg AT et al. | Environmentally friendly paper may increase risk of hand eczema in rosin-sensitive persons. | 1995 | J. Am. Acad. Dermatol. | pmid:7657866 |
| Ayars GH et al. | The toxicity of constituents of cedar and pine woods to pulmonary epithelium. | 1989 | J. Allergy Clin. Immunol. | pmid:2926083 |
| Justino GC et al. | Antioxidant activity of a catechol derived from abietic acid. | 2006 | J. Agric. Food Chem. | pmid:16417289 |
| Liu TP et al. | Pharmacological study of antithrombotic action of abietic acid. | 1985 | J Tradit Chin Med | pmid:3851113 |
| Khan L and Saeed MA | 13beta,14beta-dihydroxy-13alpha-isopropylabietic acid, an elicitor of contact allergy. | 1994 | J Pharm Sci | pmid:9120831 |
| He Y et al. | Isolation and structural elucidation of abietic acid as the main adulterant in an herbal drug for the treatment of psoriasis. | 2012 | J Pharm Biomed Anal | pmid:22482903 |
| Gardner DR et al. | Ponderosa pine and broom snakeweed: poisonous plants that affect livestock. | 1999 | J Nat Toxins | pmid:10091125 |
| Puranik PK and Dorle AK | Study of abietic acid glycerol derivatives as microencapsulating materials. | 1991 Apr-Jun | J Microencapsul | pmid:1765905 |
| Puranik PK et al. | Preparation and evaluation of abietic acid microcapsules by a solvent evaporation technique. | 1992 Oct-Dec | J Microencapsul | pmid:1403490 |
| Hwang KH et al. | Abietic acid has an anti-obesity effect in mice fed a high-fat diet. | 2011 | J Med Food | pmid:21812648 |
| Axelsson S et al. | Determination of resin acids during production of wood pellets--a comparison of HPLC/ESI-MS with the GC/FID MDHS 83/2 method. | 2011 | J Environ Monit | pmid:21874165 |
| Eriksson K et al. | Tape-stripping as a method for measuring dermal exposure to resin acids during wood pellet production. | 2008 | J Environ Monit | pmid:18392277 |
| Kim NH et al. | Tetrahydroabietic Acid, a Reduced Abietic Acid, Inhibits the Production of Inflammatory Mediators in RAW264.7 Macrophages Activated with Lipopolysaccharide. | 2010 | J Clin Biochem Nutr | pmid:20216944 |
| Lee BL et al. | High-performance liquid chromatographic determination of dehydroabietic and abietic acids in traditional Chinese medications. | 1997 | J Chromatogr A | pmid:9129324 |
| Mitani K et al. | Analysis of abietic acid and dehydroabietic acid in food samples by in-tube solid-phase microextraction coupled with liquid chromatography-mass spectrometry. | 2007 | J Chromatogr A | pmid:17306277 |