Abietic acid is a lipid of Prenol Lipids (PR) class. Abietic acid is associated with abnormalities such as Hand eczema, Dermatitis, Vitelliform dystrophy, Wiskott-Aldrich Syndrome and Dehydration. The involved functions are known as Process, Oxidation, Anabolism, Transmembrane Transport and physiological aspects. Abietic acid often locates in Membrane, Protoplasm, Microsomes and Cellular Membrane. The associated genes with Abietic acid are SLC33A1 gene and ABCG2 gene. The related lipids are Pinene.
To understand associated biological information of Abietic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Abietic acid is suspected in Hand eczema, Dermatitis, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Abietic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ulcer | D014456 | 16 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Edema | D004487 | 152 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Saito K et al. | An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. | 2017 | Toxicol In Vitro | pmid:27965148 |
| Jagalski V et al. | Biophysical study of resin acid effects on phospholipid membrane structure and properties. | 2016 | Biochim. Biophys. Acta | pmid:27544924 |
| Costa MS et al. | The conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria. | 2016 | Sci Rep | pmid:26996104 |
| Geisler K et al. | Modularity of Conifer Diterpene Resin Acid Biosynthesis: P450 Enzymes of Different CYP720B Clades Use Alternative Substrates and Converge on the Same Products. | 2016 | Plant Physiol. | pmid:26936895 |
| Sadashiva MP et al. | A non-cytotoxic N-dehydroabietylamine derivative with potent antimalarial activity. | 2015 | Exp. Parasitol. | pmid:25982031 |
| Rafferty RJ et al. | Synthesis of complex and diverse compounds through ring distortion of abietic acid. | 2014 | Angew. Chem. Int. Ed. Engl. | pmid:24273016 |
| Kazakova OB et al. | [Synthesis, structure and farmacologycal activity of (7R,8S)-epoxy-(13R,17R)-trioxolaneabietic acid]. | 2013 Mar-Apr | Bioorg. Khim. | pmid:23964524 |
| Janocha S and Bernhardt R | Design and characterization of an efficient CYP105A1-based whole-cell biocatalyst for the conversion of resin acid diterpenoids in permeabilized Escherichia coli. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23793341 |
| Wang YF and Wei XY | [Determination of dehydroabietic acid and abietic acid in aqueous alkali extract of Liquidambaris Resina by HPLC]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596877 |
| Yao F et al. | Preparation and application of abietic acid-derived optically active helical polymers and their chiral hydrogels. | 2013 | Bioresour. Technol. | pmid:23232223 |
| Janocha S et al. | Resin acid conversion with CYP105A1: an enzyme with potential for the production of pharmaceutically relevant diterpenoids. | 2013 | Chembiochem | pmid:23371760 |
| Slade JH and Knopf DA | Heterogeneous OH oxidation of biomass burning organic aerosol surrogate compounds: assessment of volatilisation products and the role of OH concentration on the reactive uptake kinetics. | 2013 | Phys Chem Chem Phys | pmid:23487256 |
| Shpatov AV et al. | Lipophilic extracts from needles and defoliated twigs of Pinus pumila from two different populations. | 2013 | Chem. Biodivers. | pmid:23418167 |
| Lauriola MM et al. | Allergic contact dermatitis from depilatory wax. | 2012 May-Jun | Dermatitis | pmid:22653175 |
| Xiao C et al. | [Study on determination methods for abietic acid in fake Myrrha]. | 2012 | Zhong Yao Cai | pmid:23320354 |
| Frank P et al. | Ancient wood of the Acqualadrone rostrum: materials history through gas chromatography/mass spectrometry and sulfur X-ray absorption spectroscopy. | 2012 | Anal. Chem. | pmid:22545724 |
| He Y et al. | Isolation and structural elucidation of abietic acid as the main adulterant in an herbal drug for the treatment of psoriasis. | 2012 | J Pharm Biomed Anal | pmid:22482903 |
| Siebert MR et al. | The need for enzymatic steering in abietic acid biosynthesis: gas-phase chemical dynamics simulations of carbocation rearrangements on a bifurcating potential energy surface. | 2011 | J. Am. Chem. Soc. | pmid:21548620 |
| Frija LM et al. | Isolation, chemical, and biotransformation routes of labdane-type diterpenes. | 2011 | Chem. Rev. | pmid:21618966 |
| Lardos A et al. | Resins and Gums in Historical Iatrosophia Texts from Cyprus - A Botanical and Medico-pharmacological Approach. | 2011 | Front Pharmacol | pmid:21772820 |
| Suhng EA et al. | A Case of Allergic Contact Dermatitis Due to DuoDERM Extrathin®. | 2011 | Ann Dermatol | pmid:22346285 |
| Schmidt A et al. | Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). | 2011 | Plant Mol. Biol. | pmid:22002747 |
| Bleif S et al. | Identification of CYP106A2 as a regioselective allylic bacterial diterpene hydroxylase. | 2011 | Chembiochem | pmid:21271628 |
| Hwang KH et al. | Abietic acid has an anti-obesity effect in mice fed a high-fat diet. | 2011 | J Med Food | pmid:21812648 |
| Axelsson S et al. | Determination of resin acids during production of wood pellets--a comparison of HPLC/ESI-MS with the GC/FID MDHS 83/2 method. | 2011 | J Environ Monit | pmid:21874165 |
| Hirai S et al. | Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies. | 2010 | Mediators Inflamm. | pmid:20508825 |
| Abbott E et al. | Laser microdissection of conifer stem tissues: isolation and analysis of high quality RNA, terpene synthase enzyme activity and terpenoid metabolites from resin ducts and cambial zone tissue of white spruce (Picea glauca). | 2010 | BMC Plant Biol. | pmid:20540781 |
| Goto T et al. | Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism. | 2010 | PPAR Res | pmid:20613991 |
| Boskabady MH et al. | Work-related respiratory symptoms and pulmonary function tests in northeast iranian (the city of Mashhad) carpenters. | 2010 | Clinics (Sao Paulo) | pmid:21120301 |
| Kim NH et al. | Tetrahydroabietic Acid, a Reduced Abietic Acid, Inhibits the Production of Inflammatory Mediators in RAW264.7 Macrophages Activated with Lipopolysaccharide. | 2010 | J Clin Biochem Nutr | pmid:20216944 |
| Keeling CI et al. | Identification and functional characterization of monofunctional ent-copalyl diphosphate and ent-kaurene synthases in white spruce reveal different patterns for diterpene synthase evolution for primary and secondary metabolism in gymnosperms. | 2010 | Plant Physiol. | pmid:20044448 |
| Rao XP | N-Morpholino-Δ-dihydro-abietamide. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588936 |
| Wang K et al. | Methyl 7-oxo-12-propyl-amino-13-nitro-deisopropyl-dehydro-abietate. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21587581 |
| Gören AC et al. | Chemical composition of natural colophony from Pinus brutia and comparison with synthetic colophony. | 2010 | Nat Prod Commun | pmid:21213968 |
| González MA et al. | Synthesis and biological evaluation of dehydroabietic acid derivatives. | 2010 | Eur J Med Chem | pmid:19892441 |
| Yang XW et al. | Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. | 2010 | Bioorg. Med. Chem. | pmid:20022253 |
| Assalin MR et al. | Combined system of activated sludge and ozonation for the treatment of kraft E1 effluent. | 2009 | Int J Environ Res Public Health | pmid:19440438 |
| Zhang M et al. | 13-Ethoxy-carbonyl-16-(1-methyl-ethyl)-17,19-dinoratis-15-ene-4,14-dicarboxylic acid monohydrate: a new derivative of maleopimaric acid. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21583637 |
| Zhang M et al. | Maleopimaric acid acetic acid solvate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21582965 |
| González MA et al. | Synthesis and biological evaluation of abietic acid derivatives. | 2009 | Eur J Med Chem | pmid:19217699 |
| Ohmori K and Kawamura Y | Cell transformation activities of abietic acid and dehydroabietic acid: safety assessment of possible contaminants in paper and paperboard for food contact use. | 2009 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:19680931 |
| Jung MJ et al. | A new abietic acid-type diterpene glucoside from the needles of Pinus densiflora. | 2009 | Arch. Pharm. Res. | pmid:20162397 |
| Yoshida N et al. | Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport. | 2008 | Drug Metab. Dispos. | pmid:18436619 |
| Di Paolo RE et al. | Picosecond structural relaxation of abietic acid based amine end capped para-phenylenevinylene trimers in solution. | 2008 | Chemphyschem | pmid:18830995 |
| Bhatia SP et al. | Fragrance material review on abietyl acetate. | 2008 | Food Chem. Toxicol. | pmid:18845214 |
| Samoylenko V et al. | Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. | 2008 | Phytother Res | pmid:19067375 |
| Eriksson K et al. | Tape-stripping as a method for measuring dermal exposure to resin acids during wood pellet production. | 2008 | J Environ Monit | pmid:18392277 |
| Smith DJ et al. | Distinct roles for two CYP226 family cytochromes P450 in abietane diterpenoid catabolism by Burkholderia xenovorans LB400. | 2008 | J. Bacteriol. | pmid:18156276 |
| Wiyono B et al. | Reaction of abietic acid with maleic anhydride and fumaric acid and attempts to find the fundamental component of fortified rosin. | 2007 | Pak. J. Biol. Sci. | pmid:19086503 |
| Talevi A et al. | Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17234417 |