Abietic acid is a lipid of Prenol Lipids (PR) class. Abietic acid is associated with abnormalities such as Hand eczema, Dermatitis, Vitelliform dystrophy, Wiskott-Aldrich Syndrome and Dehydration. The involved functions are known as Process, Oxidation, Anabolism, Transmembrane Transport and physiological aspects. Abietic acid often locates in Membrane, Protoplasm, Microsomes and Cellular Membrane. The associated genes with Abietic acid are SLC33A1 gene and ABCG2 gene. The related lipids are Pinene.
To understand associated biological information of Abietic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Abietic acid is suspected in Hand eczema, Dermatitis, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Abietic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
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| pmid:26795242 | ||||
| pmid:16904803 | ||||
| pmid:18666177 | ||||
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| Foussereau J et al. | [Allergologic studies of intolerance to rosin]. | 1980 | Derm Beruf Umwelt | pmid:7408638 |
| Fujita Y et al. | New hypocholesterolemic abietamide derivatives. I. Structure-activity relationship. | 1980 | Chem. Pharm. Bull. | pmid:7389019 |
| Burge PS et al. | Bronchial provocation studies in workers exposed to the fumes of electronic soldering fluxes. | 1980 | Clin. Allergy | pmid:7389068 |
| Fisher AA | Allergic contact dermatitis in a violinist. The role of abietic acid--a sensitizer in rosin (colophony)--as the causative agent. | 1981 | Cutis | pmid:7016461 |
| Fisher AA | Paper dermatitis. | 1983 | Cutis | pmid:6406159 |
| Liu TP et al. | Pharmacological study of antithrombotic action of abietic acid. | 1985 | J Tradit Chin Med | pmid:3851113 |
| Karlberg AT et al. | Is abietic acid the allergenic component of colophony? | 1985 | Contact Derm. | pmid:4085221 |
| Nakamura T | Contact dermatitis to Japanese black pine. | 1986 | Contact Derm. | pmid:3743045 |
| Karlberg AT et al. | Identification of 15-hydroperoxyabietic acid as a contact allergen in Portuguese colophony. | 1988 | J. Pharm. Pharmacol. | pmid:2896772 |
| Karlberg AT et al. | Hydrogenation reduces the allergenicity of colophony (rosin). | 1988 | Contact Derm. | pmid:3180766 |
| Karlberg AT | Contact allergy to colophony. Chemical identifications of allergens, sensitization experiments and clinical experiences. | 1988 | Acta Derm Venereol Suppl (Stockh) | pmid:3188806 |
| Karlberg AT | Pure abietic acid is not allergenic. | 1989 | Contact Derm. | pmid:2598660 |
| Ayars GH et al. | The toxicity of constituents of cedar and pine woods to pulmonary epithelium. | 1989 | J. Allergy Clin. Immunol. | pmid:2926083 |
| Hausen BM et al. | Contact allergy due to colophony (VII). Sensitizing studies with oxidation products of abietic and related acids. | 1990 | Contact Derm. | pmid:2096024 |
| Ehrin E and Karlberg AT | Detection of rosin (colophony) components in technical products using an HPLC technique. | 1990 | Contact Derm. | pmid:2096025 |
| Söderberg TA | Effects of zinc oxide, rosin and resin acids and their combinations on bacterial growth and inflammatory cells. | 1990 | Scand J Plast Reconstr Surg Hand Surg Suppl | pmid:2284587 |
| Söderberg TA et al. | Antibacterial effects of zinc oxide, rosin, and resin acids with special reference to their interactions. | 1991 | Scand J Plast Reconstr Surg Hand Surg | pmid:2052904 |
| Patel GB et al. | Inhibition of pure cultures of methanogens by benzene ring compounds. | 1991 | Appl. Environ. Microbiol. | pmid:1746956 |
| Orpiszewski J et al. | Multiple forms of O-methyltransferase involved in the microbial conversion of abietic acid into methyl abietate by Mycobacterium sp. | 1991 | FEMS Microbiol. Lett. | pmid:1936951 |
| Puranik PK and Dorle AK | Study of abietic acid glycerol derivatives as microencapsulating materials. | 1991 Apr-Jun | J Microencapsul | pmid:1765905 |
| Karlberg AT and Lidén C | Colophony (rosin) in newspapers may contribute to hand eczema. | 1992 | Br. J. Dermatol. | pmid:1536781 |
| Puranik PK et al. | Preparation and evaluation of abietic acid microcapsules by a solvent evaporation technique. | 1992 Oct-Dec | J Microencapsul | pmid:1403490 |
| Hausen BM et al. | Contact allergy due to colophony. (IX). Sensitization studies with further products isolated after oxidative degradation of resin acids and colophony. | 1993 | Contact Derm. | pmid:8112061 |
| Shao LP et al. | The allergenicity of glycerol esters and other esters of rosin (colophony). | 1993 | Contact Derm. | pmid:8508634 |
| Nicholson RA | The actions of abietic acid in mammalian synaptosomal preparations. | 1994 | Biochem. Soc. Trans. | pmid:7958288 |
| Matsuya Y and Matsuya S | Effect of abietic acid and poly(methyl methacrylate) on the dissolution process of zinc oxide-eugenol cement. | 1994 | Biomaterials | pmid:8031992 |
| Funk C and Croteau R | Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. | 1994 | Arch. Biochem. Biophys. | pmid:8311462 |
| LaFever RE et al. | Diterpenoid resin acid biosynthesis in conifers: enzymatic cyclization of geranylgeranyl pyrophosphate to abietadiene, the precursor of abietic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8053674 |
| Khan L and Saeed MA | 13beta,14beta-dihydroxy-13alpha-isopropylabietic acid, an elicitor of contact allergy. | 1994 | J Pharm Sci | pmid:9120831 |
| Bergh M et al. | Colophony in paper-based surgical clothing. | 1994 | Contact Derm. | pmid:7867341 |
| Koh D et al. | Colophony in bindi adhesive. | 1995 | Contact Derm. | pmid:7774206 |
| Karlberg AT et al. | Environmentally friendly paper may increase risk of hand eczema in rosin-sensitive persons. | 1995 | J. Am. Acad. Dermatol. | pmid:7657866 |
| Gäfvert E and Färm G | Rosin (colophony) and zinc oxide in adhesive bandages. An appropriate combination for rosin-sensitive patients? | 1995 | Contact Derm. | pmid:8706397 |
| el Sayed F et al. | Contact urticaria from abietic acid. | 1995 | Contact Derm. | pmid:7554886 |
| Johansson A et al. | Antimicrobial screening of zinc in the absence or presence of oleoresins and various resin acids. | 1995 | APMIS | pmid:7546644 |
| Karlberg AT and Magnusson K | Rosin components identified in diapers. | 1996 | Contact Derm. | pmid:8833460 |
| Sadhra S et al. | Identification of contact allergens in unmodified rosin using a combination of patch testing and analytical chemistry techniques. | 1996 | Br. J. Dermatol. | pmid:8733367 |
| Smith PA et al. | Sampling and analysis of airborne resin acids and solvent-soluble material derived from heated colophony (rosin) flux: a method to quantify exposure to sensitizing compounds liberated during electronics soldering. | 1996 | Toxicology | pmid:8711739 |
| Vogel BS et al. | Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis. | 1996 | J. Biol. Chem. | pmid:8798524 |
| Aranda FJ and VillalaÃn J | The interaction of abietic acid with phospholipid membranes. | 1997 | Biochim. Biophys. Acta | pmid:9271259 |
| VillalaÃn J | Location of the toxic molecule abietic acid in model membranes by MAS-NMR. | 1997 | Biochim. Biophys. Acta | pmid:9315624 |
| Smith PA et al. | Detection of resin acid compounds in airborne particulate generated from rosin used as a soldering flux. | 1997 | Am Ind Hyg Assoc J | pmid:9425647 |
| Pacheco M and Santos MA | Induction of EROD activity and genotoxic effects by polycyclic aromatic hydrocarbons and resin acids on the juvenile eel (Anguilla anguilla L.). | 1997 | Ecotoxicol. Environ. Saf. | pmid:9469877 |
| Lee BL et al. | High-performance liquid chromatographic determination of dehydroabietic and abietic acids in traditional Chinese medications. | 1997 | J Chromatogr A | pmid:9129324 |
| Smith PA et al. | Oxidized resin acids in aerosol derived from rosin core solder. | 1998 | Am Ind Hyg Assoc J | pmid:9866169 |
| Sousa Neto MD et al. | The influence of different grades of rosins and hydrogenated resins on the powder-liquid ratio of Grossman cements. | 1998 | Braz Dent J | pmid:9835799 |
| Gardner DR et al. | Ponderosa pine and broom snakeweed: poisonous plants that affect livestock. | 1999 | J Nat Toxins | pmid:10091125 |
| Fâhraeus-Van Ree GE and Payne JF | Enzyme cytochemical responses of mussels (Mytilus edulis) to resin acid constituents of pulp mill effluents. | 1999 | Bull Environ Contam Toxicol | pmid:10501718 |
| Demers PA et al. | Exposure to dust, resin acids, and monoterpenes in softwood lumber mills. | 2000 Jul-Aug | AIHAJ | pmid:10976682 |
| Ohtsu H et al. | Abietane diterpenoids from the cones of Larix kaempferi and their inhibitory effects on Epstein-Barr virus activation. | 2001 | Planta Med. | pmid:11270723 |
| Esteves MA et al. | Synthetic derivatives of abietic acid with radical scavenging activity. | 2001 | J. Nat. Prod. | pmid:11421739 |
| Fernández MA et al. | Anti-inflammatory activity of abietic acid, a diterpene isolated from Pimenta racemosa var. grissea. | 2001 | J. Pharm. Pharmacol. | pmid:11428663 |
| Morgan CA and Wyndham RC | Characterization of tdt genes for the degradation of tricyclic diterpenes by Pseudomonas diterpeniphila A19-6a. | 2002 | Can. J. Microbiol. | pmid:11888163 |
| Imaizumi Y et al. | Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. | 2002 | Mol. Pharmacol. | pmid:12237330 |
| Gravato C and Santos MA | Juvenile sea bass liver biotransformation induction and erythrocytic genotoxic responses to resin acids. | 2002 | Ecotoxicol. Environ. Saf. | pmid:12297086 |
| Prinz S et al. | Oxidation products of abietic acid and its methyl ester. | 2002 | J. Nat. Prod. | pmid:12444672 |
| Fransman W et al. | Respiratory symptoms and occupational exposures in New Zealand plywood mill workers. | 2003 | Ann Occup Hyg | pmid:12765869 |
| Gigante B et al. | Catechols from abietic acid synthesis and evaluation as bioactive compounds. | 2003 | Bioorg. Med. Chem. | pmid:12659748 |
| Arnó M et al. | Synthesis of C-17-functionalized spongiane diterpenes: diastereoselective synthesis of (-)-spongian-16-oxo-17-al, (-)-acetyldendrillol-1, and (-)-aplyroseol-14. | 2003 | J. Org. Chem. | pmid:12585861 |
| Quinn BP et al. | Selected resin acids in effluent and receiving waters derived from a bleached and unbleached kraft pulp and paper mill. | 2003 | Environ. Toxicol. Chem. | pmid:12503767 |
| Takahashi N et al. | Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism. | 2003 | FEBS Lett. | pmid:12935909 |
| Seal AN et al. | Identification and quantitation of compounds in a series of allelopathic and non-allelopathic rice root exudates. | 2004 | J. Chem. Ecol. | pmid:15537165 |
| Seal AN et al. | Evaluation of putative allelochemicals in rice root exudates for their role in the suppression of arrowhead root growth. | 2004 | J. Chem. Ecol. | pmid:15537166 |