Abietic acid is a lipid of Prenol Lipids (PR) class. Abietic acid is associated with abnormalities such as Hand eczema, Dermatitis, Vitelliform dystrophy, Wiskott-Aldrich Syndrome and Dehydration. The involved functions are known as Process, Oxidation, Anabolism, Transmembrane Transport and physiological aspects. Abietic acid often locates in Membrane, Protoplasm, Microsomes and Cellular Membrane. The associated genes with Abietic acid are SLC33A1 gene and ABCG2 gene. The related lipids are Pinene.
To understand associated biological information of Abietic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Abietic acid is suspected in Hand eczema, Dermatitis, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Abietic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma | D001249 | 52 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smith PA et al. | Oxidized resin acids in aerosol derived from rosin core solder. | 1998 | Am Ind Hyg Assoc J | pmid:9866169 |
| Sousa Neto MD et al. | The influence of different grades of rosins and hydrogenated resins on the powder-liquid ratio of Grossman cements. | 1998 | Braz Dent J | pmid:9835799 |
| Pacheco M and Santos MA | Induction of EROD activity and genotoxic effects by polycyclic aromatic hydrocarbons and resin acids on the juvenile eel (Anguilla anguilla L.). | 1997 | Ecotoxicol. Environ. Saf. | pmid:9469877 |
| Smith PA et al. | Detection of resin acid compounds in airborne particulate generated from rosin used as a soldering flux. | 1997 | Am Ind Hyg Assoc J | pmid:9425647 |
| VillalaÃn J | Location of the toxic molecule abietic acid in model membranes by MAS-NMR. | 1997 | Biochim. Biophys. Acta | pmid:9315624 |
| Aranda FJ and VillalaÃn J | The interaction of abietic acid with phospholipid membranes. | 1997 | Biochim. Biophys. Acta | pmid:9271259 |
| Lee BL et al. | High-performance liquid chromatographic determination of dehydroabietic and abietic acids in traditional Chinese medications. | 1997 | J Chromatogr A | pmid:9129324 |
| Khan L and Saeed MA | 13beta,14beta-dihydroxy-13alpha-isopropylabietic acid, an elicitor of contact allergy. | 1994 | J Pharm Sci | pmid:9120831 |
| Karlberg AT and Magnusson K | Rosin components identified in diapers. | 1996 | Contact Derm. | pmid:8833460 |
| Vogel BS et al. | Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis. | 1996 | J. Biol. Chem. | pmid:8798524 |
| Sadhra S et al. | Identification of contact allergens in unmodified rosin using a combination of patch testing and analytical chemistry techniques. | 1996 | Br. J. Dermatol. | pmid:8733367 |
| Smith PA et al. | Sampling and analysis of airborne resin acids and solvent-soluble material derived from heated colophony (rosin) flux: a method to quantify exposure to sensitizing compounds liberated during electronics soldering. | 1996 | Toxicology | pmid:8711739 |
| Gäfvert E and Färm G | Rosin (colophony) and zinc oxide in adhesive bandages. An appropriate combination for rosin-sensitive patients? | 1995 | Contact Derm. | pmid:8706397 |
| Shao LP et al. | The allergenicity of glycerol esters and other esters of rosin (colophony). | 1993 | Contact Derm. | pmid:8508634 |
| Funk C and Croteau R | Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. | 1994 | Arch. Biochem. Biophys. | pmid:8311462 |
| Hausen BM et al. | Contact allergy due to colophony. (IX). Sensitization studies with further products isolated after oxidative degradation of resin acids and colophony. | 1993 | Contact Derm. | pmid:8112061 |
| LaFever RE et al. | Diterpenoid resin acid biosynthesis in conifers: enzymatic cyclization of geranylgeranyl pyrophosphate to abietadiene, the precursor of abietic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8053674 |
| Matsuya Y and Matsuya S | Effect of abietic acid and poly(methyl methacrylate) on the dissolution process of zinc oxide-eugenol cement. | 1994 | Biomaterials | pmid:8031992 |
| Nicholson RA | The actions of abietic acid in mammalian synaptosomal preparations. | 1994 | Biochem. Soc. Trans. | pmid:7958288 |
| Bergh M et al. | Colophony in paper-based surgical clothing. | 1994 | Contact Derm. | pmid:7867341 |
| Koh D et al. | Colophony in bindi adhesive. | 1995 | Contact Derm. | pmid:7774206 |
| Karlberg AT et al. | Environmentally friendly paper may increase risk of hand eczema in rosin-sensitive persons. | 1995 | J. Am. Acad. Dermatol. | pmid:7657866 |
| el Sayed F et al. | Contact urticaria from abietic acid. | 1995 | Contact Derm. | pmid:7554886 |
| Johansson A et al. | Antimicrobial screening of zinc in the absence or presence of oleoresins and various resin acids. | 1995 | APMIS | pmid:7546644 |
| Foussereau J et al. | [Allergologic studies of intolerance to rosin]. | 1980 | Derm Beruf Umwelt | pmid:7408638 |
| Burge PS et al. | Bronchial provocation studies in workers exposed to the fumes of electronic soldering fluxes. | 1980 | Clin. Allergy | pmid:7389068 |
| Fujita Y et al. | New hypocholesterolemic abietamide derivatives. I. Structure-activity relationship. | 1980 | Chem. Pharm. Bull. | pmid:7389019 |
| Fisher AA | Allergic contact dermatitis in a violinist. The role of abietic acid--a sensitizer in rosin (colophony)--as the causative agent. | 1981 | Cutis | pmid:7016461 |
| Fisher AA | Paper dermatitis. | 1983 | Cutis | pmid:6406159 |
| Karlberg AT et al. | Is abietic acid the allergenic component of colophony? | 1985 | Contact Derm. | pmid:4085221 |
| Liu TP et al. | Pharmacological study of antithrombotic action of abietic acid. | 1985 | J Tradit Chin Med | pmid:3851113 |
| Nakamura T | Contact dermatitis to Japanese black pine. | 1986 | Contact Derm. | pmid:3743045 |
| Karlberg AT | Contact allergy to colophony. Chemical identifications of allergens, sensitization experiments and clinical experiences. | 1988 | Acta Derm Venereol Suppl (Stockh) | pmid:3188806 |
| Karlberg AT et al. | Hydrogenation reduces the allergenicity of colophony (rosin). | 1988 | Contact Derm. | pmid:3180766 |
| Ayars GH et al. | The toxicity of constituents of cedar and pine woods to pulmonary epithelium. | 1989 | J. Allergy Clin. Immunol. | pmid:2926083 |
| Karlberg AT et al. | Identification of 15-hydroperoxyabietic acid as a contact allergen in Portuguese colophony. | 1988 | J. Pharm. Pharmacol. | pmid:2896772 |
| pmid:28423677 | ||||
| pmid:28389357 | ||||
| Saito K et al. | An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. | 2017 | Toxicol In Vitro | pmid:27965148 |
| pmid:27793449 | ||||
| Jagalski V et al. | Biophysical study of resin acid effects on phospholipid membrane structure and properties. | 2016 | Biochim. Biophys. Acta | pmid:27544924 |
| pmid:27318791 | ||||
| Costa MS et al. | The conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria. | 2016 | Sci Rep | pmid:26996104 |
| Geisler K et al. | Modularity of Conifer Diterpene Resin Acid Biosynthesis: P450 Enzymes of Different CYP720B Clades Use Alternative Substrates and Converge on the Same Products. | 2016 | Plant Physiol. | pmid:26936895 |
| pmid:26864272 | ||||
| pmid:26795242 | ||||
| pmid:26621449 | ||||
| pmid:26164238 | ||||
| Karlberg AT | Pure abietic acid is not allergenic. | 1989 | Contact Derm. | pmid:2598660 |
| Sadashiva MP et al. | A non-cytotoxic N-dehydroabietylamine derivative with potent antimalarial activity. | 2015 | Exp. Parasitol. | pmid:25982031 |