Abietic acid is a lipid of Prenol Lipids (PR) class. Abietic acid is associated with abnormalities such as Hand eczema, Dermatitis, Vitelliform dystrophy, Wiskott-Aldrich Syndrome and Dehydration. The involved functions are known as Process, Oxidation, Anabolism, Transmembrane Transport and physiological aspects. Abietic acid often locates in Membrane, Protoplasm, Microsomes and Cellular Membrane. The associated genes with Abietic acid are SLC33A1 gene and ABCG2 gene. The related lipids are Pinene.
To understand associated biological information of Abietic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Abietic acid is suspected in Hand eczema, Dermatitis, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Abietic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asthma | D001249 | 52 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| pmid:22594762 | ||||
| Lauriola MM et al. | Allergic contact dermatitis from depilatory wax. | 2012 May-Jun | Dermatitis | pmid:22653175 |
| Söderberg TA | Effects of zinc oxide, rosin and resin acids and their combinations on bacterial growth and inflammatory cells. | 1990 | Scand J Plast Reconstr Surg Hand Surg Suppl | pmid:2284587 |
| Yao F et al. | Preparation and application of abietic acid-derived optically active helical polymers and their chiral hydrogels. | 2013 | Bioresour. Technol. | pmid:23232223 |
| Xiao C et al. | [Study on determination methods for abietic acid in fake Myrrha]. | 2012 | Zhong Yao Cai | pmid:23320354 |
| Janocha S et al. | Resin acid conversion with CYP105A1: an enzyme with potential for the production of pharmaceutically relevant diterpenoids. | 2013 | Chembiochem | pmid:23371760 |
| Shpatov AV et al. | Lipophilic extracts from needles and defoliated twigs of Pinus pumila from two different populations. | 2013 | Chem. Biodivers. | pmid:23418167 |
| Slade JH and Knopf DA | Heterogeneous OH oxidation of biomass burning organic aerosol surrogate compounds: assessment of volatilisation products and the role of OH concentration on the reactive uptake kinetics. | 2013 | Phys Chem Chem Phys | pmid:23487256 |
| Wang YF and Wei XY | [Determination of dehydroabietic acid and abietic acid in aqueous alkali extract of Liquidambaris Resina by HPLC]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596877 |
| Janocha S and Bernhardt R | Design and characterization of an efficient CYP105A1-based whole-cell biocatalyst for the conversion of resin acid diterpenoids in permeabilized Escherichia coli. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23793341 |
| Kazakova OB et al. | [Synthesis, structure and farmacologycal activity of (7R,8S)-epoxy-(13R,17R)-trioxolaneabietic acid]. | 2013 Mar-Apr | Bioorg. Khim. | pmid:23964524 |
| Rafferty RJ et al. | Synthesis of complex and diverse compounds through ring distortion of abietic acid. | 2014 | Angew. Chem. Int. Ed. Engl. | pmid:24273016 |
| pmid:24735394 | ||||
| pmid:24906785 | ||||
| pmid:25104764 | ||||
| pmid:25200370 | ||||
| pmid:25456583 | ||||
| pmid:25462275 | ||||
| pmid:25496486 | ||||
| pmid:25686209 | ||||
| pmid:25939920 | ||||
| Sadashiva MP et al. | A non-cytotoxic N-dehydroabietylamine derivative with potent antimalarial activity. | 2015 | Exp. Parasitol. | pmid:25982031 |
| Karlberg AT | Pure abietic acid is not allergenic. | 1989 | Contact Derm. | pmid:2598660 |
| pmid:26164238 | ||||
| pmid:26621449 | ||||
| pmid:26795242 | ||||
| pmid:26864272 | ||||
| Geisler K et al. | Modularity of Conifer Diterpene Resin Acid Biosynthesis: P450 Enzymes of Different CYP720B Clades Use Alternative Substrates and Converge on the Same Products. | 2016 | Plant Physiol. | pmid:26936895 |
| Costa MS et al. | The conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria. | 2016 | Sci Rep | pmid:26996104 |
| pmid:27318791 | ||||
| Jagalski V et al. | Biophysical study of resin acid effects on phospholipid membrane structure and properties. | 2016 | Biochim. Biophys. Acta | pmid:27544924 |
| pmid:27793449 | ||||
| Saito K et al. | An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. | 2017 | Toxicol In Vitro | pmid:27965148 |
| pmid:28389357 | ||||
| pmid:28423677 | ||||
| Karlberg AT et al. | Identification of 15-hydroperoxyabietic acid as a contact allergen in Portuguese colophony. | 1988 | J. Pharm. Pharmacol. | pmid:2896772 |
| Ayars GH et al. | The toxicity of constituents of cedar and pine woods to pulmonary epithelium. | 1989 | J. Allergy Clin. Immunol. | pmid:2926083 |
| Karlberg AT et al. | Hydrogenation reduces the allergenicity of colophony (rosin). | 1988 | Contact Derm. | pmid:3180766 |
| Karlberg AT | Contact allergy to colophony. Chemical identifications of allergens, sensitization experiments and clinical experiences. | 1988 | Acta Derm Venereol Suppl (Stockh) | pmid:3188806 |
| Nakamura T | Contact dermatitis to Japanese black pine. | 1986 | Contact Derm. | pmid:3743045 |
| Liu TP et al. | Pharmacological study of antithrombotic action of abietic acid. | 1985 | J Tradit Chin Med | pmid:3851113 |
| Karlberg AT et al. | Is abietic acid the allergenic component of colophony? | 1985 | Contact Derm. | pmid:4085221 |
| Fisher AA | Paper dermatitis. | 1983 | Cutis | pmid:6406159 |
| Fisher AA | Allergic contact dermatitis in a violinist. The role of abietic acid--a sensitizer in rosin (colophony)--as the causative agent. | 1981 | Cutis | pmid:7016461 |
| Fujita Y et al. | New hypocholesterolemic abietamide derivatives. I. Structure-activity relationship. | 1980 | Chem. Pharm. Bull. | pmid:7389019 |
| Burge PS et al. | Bronchial provocation studies in workers exposed to the fumes of electronic soldering fluxes. | 1980 | Clin. Allergy | pmid:7389068 |
| Foussereau J et al. | [Allergologic studies of intolerance to rosin]. | 1980 | Derm Beruf Umwelt | pmid:7408638 |
| Johansson A et al. | Antimicrobial screening of zinc in the absence or presence of oleoresins and various resin acids. | 1995 | APMIS | pmid:7546644 |
| el Sayed F et al. | Contact urticaria from abietic acid. | 1995 | Contact Derm. | pmid:7554886 |
| Karlberg AT et al. | Environmentally friendly paper may increase risk of hand eczema in rosin-sensitive persons. | 1995 | J. Am. Acad. Dermatol. | pmid:7657866 |
| Koh D et al. | Colophony in bindi adhesive. | 1995 | Contact Derm. | pmid:7774206 |
| Bergh M et al. | Colophony in paper-based surgical clothing. | 1994 | Contact Derm. | pmid:7867341 |
| Nicholson RA | The actions of abietic acid in mammalian synaptosomal preparations. | 1994 | Biochem. Soc. Trans. | pmid:7958288 |
| Matsuya Y and Matsuya S | Effect of abietic acid and poly(methyl methacrylate) on the dissolution process of zinc oxide-eugenol cement. | 1994 | Biomaterials | pmid:8031992 |
| LaFever RE et al. | Diterpenoid resin acid biosynthesis in conifers: enzymatic cyclization of geranylgeranyl pyrophosphate to abietadiene, the precursor of abietic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8053674 |
| Hausen BM et al. | Contact allergy due to colophony. (IX). Sensitization studies with further products isolated after oxidative degradation of resin acids and colophony. | 1993 | Contact Derm. | pmid:8112061 |
| Funk C and Croteau R | Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. | 1994 | Arch. Biochem. Biophys. | pmid:8311462 |
| Shao LP et al. | The allergenicity of glycerol esters and other esters of rosin (colophony). | 1993 | Contact Derm. | pmid:8508634 |
| Gäfvert E and Färm G | Rosin (colophony) and zinc oxide in adhesive bandages. An appropriate combination for rosin-sensitive patients? | 1995 | Contact Derm. | pmid:8706397 |
| Smith PA et al. | Sampling and analysis of airborne resin acids and solvent-soluble material derived from heated colophony (rosin) flux: a method to quantify exposure to sensitizing compounds liberated during electronics soldering. | 1996 | Toxicology | pmid:8711739 |
| Sadhra S et al. | Identification of contact allergens in unmodified rosin using a combination of patch testing and analytical chemistry techniques. | 1996 | Br. J. Dermatol. | pmid:8733367 |
| Vogel BS et al. | Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis. | 1996 | J. Biol. Chem. | pmid:8798524 |
| Karlberg AT and Magnusson K | Rosin components identified in diapers. | 1996 | Contact Derm. | pmid:8833460 |
| Khan L and Saeed MA | 13beta,14beta-dihydroxy-13alpha-isopropylabietic acid, an elicitor of contact allergy. | 1994 | J Pharm Sci | pmid:9120831 |
| Lee BL et al. | High-performance liquid chromatographic determination of dehydroabietic and abietic acids in traditional Chinese medications. | 1997 | J Chromatogr A | pmid:9129324 |
| Aranda FJ and VillalaÃn J | The interaction of abietic acid with phospholipid membranes. | 1997 | Biochim. Biophys. Acta | pmid:9271259 |
| VillalaÃn J | Location of the toxic molecule abietic acid in model membranes by MAS-NMR. | 1997 | Biochim. Biophys. Acta | pmid:9315624 |
| Smith PA et al. | Detection of resin acid compounds in airborne particulate generated from rosin used as a soldering flux. | 1997 | Am Ind Hyg Assoc J | pmid:9425647 |
| Pacheco M and Santos MA | Induction of EROD activity and genotoxic effects by polycyclic aromatic hydrocarbons and resin acids on the juvenile eel (Anguilla anguilla L.). | 1997 | Ecotoxicol. Environ. Saf. | pmid:9469877 |
| Sousa Neto MD et al. | The influence of different grades of rosins and hydrogenated resins on the powder-liquid ratio of Grossman cements. | 1998 | Braz Dent J | pmid:9835799 |
| Smith PA et al. | Oxidized resin acids in aerosol derived from rosin core solder. | 1998 | Am Ind Hyg Assoc J | pmid:9866169 |