Abietic acid is a lipid of Prenol Lipids (PR) class. Abietic acid is associated with abnormalities such as Hand eczema, Dermatitis, Vitelliform dystrophy, Wiskott-Aldrich Syndrome and Dehydration. The involved functions are known as Process, Oxidation, Anabolism, Transmembrane Transport and physiological aspects. Abietic acid often locates in Membrane, Protoplasm, Microsomes and Cellular Membrane. The associated genes with Abietic acid are SLC33A1 gene and ABCG2 gene. The related lipids are Pinene.
To understand associated biological information of Abietic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Abietic acid is suspected in Hand eczema, Dermatitis, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Abietic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Gain | D015430 | 101 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Asthma | D001249 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jung MJ et al. | A new abietic acid-type diterpene glucoside from the needles of Pinus densiflora. | 2009 | Arch. Pharm. Res. | pmid:20162397 |
| Keeling CI et al. | Identification and functional characterization of monofunctional ent-copalyl diphosphate and ent-kaurene synthases in white spruce reveal different patterns for diterpene synthase evolution for primary and secondary metabolism in gymnosperms. | 2010 | Plant Physiol. | pmid:20044448 |
| Yang XW et al. | Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. | 2010 | Bioorg. Med. Chem. | pmid:20022253 |
| González MA et al. | Synthesis and biological evaluation of dehydroabietic acid derivatives. | 2010 | Eur J Med Chem | pmid:19892441 |
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| Orpiszewski J et al. | Multiple forms of O-methyltransferase involved in the microbial conversion of abietic acid into methyl abietate by Mycobacterium sp. | 1991 | FEMS Microbiol. Lett. | pmid:1936951 |
| González MA et al. | Synthesis and biological evaluation of abietic acid derivatives. | 2009 | Eur J Med Chem | pmid:19217699 |
| pmid:19101885 | ||||
| Wiyono B et al. | Reaction of abietic acid with maleic anhydride and fumaric acid and attempts to find the fundamental component of fortified rosin. | 2007 | Pak. J. Biol. Sci. | pmid:19086503 |
| Samoylenko V et al. | Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. | 2008 | Phytother Res | pmid:19067375 |
| Bhatia SP et al. | Fragrance material review on abietyl acetate. | 2008 | Food Chem. Toxicol. | pmid:18845214 |
| Di Paolo RE et al. | Picosecond structural relaxation of abietic acid based amine end capped para-phenylenevinylene trimers in solution. | 2008 | Chemphyschem | pmid:18830995 |
| pmid:18666177 | ||||
| Yoshida N et al. | Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport. | 2008 | Drug Metab. Dispos. | pmid:18436619 |
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| Smith DJ et al. | A large gene cluster in Burkholderia xenovorans encoding abietane diterpenoid catabolism. | 2007 | J. Bacteriol. | pmid:17586638 |
| pmid:17577378 | ||||
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| pmid:17352501 | ||||
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| Belmonte M et al. | Effect of aerobic sludge with increasing level of adaptation on abietic acid biodegradation. | 2006 | Bull Environ Contam Toxicol | pmid:17219306 |
| Shaneyfelt ME et al. | Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay. | 2006 | Virol. J. | pmid:16948846 |
| pmid:16904803 | ||||
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| Ozaki A et al. | Migration of dehydroabietic and abietic acids from paper and paperboard food packaging into food-simulating solvents and Tenax TA. | 2006 | Food Addit Contam | pmid:16807212 |
| Anderson KB | The nature and fate of natural resins in the geosphere. XII. Investigation of C-ring aromatic diterpenoids in Raritan amber by pyrolysis-GC-matrix isolation FTIR-MS. | 2006 | Geochem. Trans. | pmid:16759406 |
| Keeling CI and Bohlmann J | Genes, enzymes and chemicals of terpenoid diversity in the constitutive and induced defence of conifers against insects and pathogens. | 2006 | New Phytol. | pmid:16684230 |
| pmid:16643007 | ||||
| Justino GC et al. | Antioxidant activity of a catechol derived from abietic acid. | 2006 | J. Agric. Food Chem. | pmid:16417289 |
| Belmonte M et al. | Improved aerobic biodegradation of abietic acid in ECF bleached kraft mill effluent due to biomass adaptation. | 2006 | J. Hazard. Mater. | pmid:16386835 |
| Ozaki A et al. | Safety assessment of paper and board food packaging: chemical analysis and genotoxicity of possible contaminants in packaging. | 2005 | Food Addit Contam | pmid:16227189 |
| Mitsukura K et al. | Regio- and stereo-selective hydroxylation of abietic acid derivatives by Mucor circinelloides and Mortierella isabellina. | 2005 | Biotechnol. Lett. | pmid:16215830 |
| Sakamoto K et al. | Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16195419 |
| Smith E et al. | Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus. | 2005 | Phytother Res | pmid:16114093 |
| Gravato C et al. | Oxidative stress and genotoxic responses to resin acids in Mediterranean mussels. | 2005 | Ecotoxicol. Environ. Saf. | pmid:15883093 |
| Kamaya Y et al. | Effects of dehydroabietic acid and abietic acid on survival, reproduction, and growth of the crustacean Daphnia magna. | 2005 | Ecotoxicol. Environ. Saf. | pmid:15814313 |
| Clement YN et al. | Medicinal herb use among asthmatic patients attending a specialty care facility in Trinidad. | 2005 | BMC Complement Altern Med | pmid:15713232 |
| Seal AN et al. | Evaluation of putative allelochemicals in rice root exudates for their role in the suppression of arrowhead root growth. | 2004 | J. Chem. Ecol. | pmid:15537166 |
| Seal AN et al. | Identification and quantitation of compounds in a series of allelopathic and non-allelopathic rice root exudates. | 2004 | J. Chem. Ecol. | pmid:15537165 |
| Nuopponen M et al. | A UV resonance Raman (UVRR) spectroscopic study on the extractable compounds of Scots pine (Pinus sylvestris) wood. Part I: lipophilic compounds. | 2004 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:15477130 |
| Karlberg AT and Lidén C | Colophony (rosin) in newspapers may contribute to hand eczema. | 1992 | Br. J. Dermatol. | pmid:1536781 |
| Maria VL et al. | Anguilla anguilla L. genotoxic and liver biotransformation responses to abietic acid exposure. | 2004 | Ecotoxicol. Environ. Saf. | pmid:15157574 |
| Gambichler T et al. | Contact dermatitis and other skin conditions in instrumental musicians. | 2004 | BMC Dermatol. | pmid:15090069 |
| Eriksson K et al. | Dermal exposure to terpenic resin acids in Swedish carpentry workshops and sawmills. | 2004 | Ann Occup Hyg | pmid:15059803 |
| pmid:14753721 | ||||
| pmid:14654249 | ||||
| Teles M et al. | Anguilla anguilla L. plasma cortisol, lactate and glucose responses to abietic acid, dehydroabietic acid and retene. | 2004 | Environ Int | pmid:14592577 |
| Puranik PK et al. | Preparation and evaluation of abietic acid microcapsules by a solvent evaporation technique. | 1992 Oct-Dec | J Microencapsul | pmid:1403490 |
| pmid:13228858 | ||||
| Takahashi N et al. | Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism. | 2003 | FEBS Lett. | pmid:12935909 |
| Fransman W et al. | Respiratory symptoms and occupational exposures in New Zealand plywood mill workers. | 2003 | Ann Occup Hyg | pmid:12765869 |
| Gigante B et al. | Catechols from abietic acid synthesis and evaluation as bioactive compounds. | 2003 | Bioorg. Med. Chem. | pmid:12659748 |
| Arnó M et al. | Synthesis of C-17-functionalized spongiane diterpenes: diastereoselective synthesis of (-)-spongian-16-oxo-17-al, (-)-acetyldendrillol-1, and (-)-aplyroseol-14. | 2003 | J. Org. Chem. | pmid:12585861 |
| Quinn BP et al. | Selected resin acids in effluent and receiving waters derived from a bleached and unbleached kraft pulp and paper mill. | 2003 | Environ. Toxicol. Chem. | pmid:12503767 |
| pmid:12481865 | ||||
| Prinz S et al. | Oxidation products of abietic acid and its methyl ester. | 2002 | J. Nat. Prod. | pmid:12444672 |
| Gravato C and Santos MA | Juvenile sea bass liver biotransformation induction and erythrocytic genotoxic responses to resin acids. | 2002 | Ecotoxicol. Environ. Saf. | pmid:12297086 |
| Imaizumi Y et al. | Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. | 2002 | Mol. Pharmacol. | pmid:12237330 |
| pmid:12000325 | ||||
| Morgan CA and Wyndham RC | Characterization of tdt genes for the degradation of tricyclic diterpenes by Pseudomonas diterpeniphila A19-6a. | 2002 | Can. J. Microbiol. | pmid:11888163 |
| Fernández MA et al. | Anti-inflammatory activity of abietic acid, a diterpene isolated from Pimenta racemosa var. grissea. | 2001 | J. Pharm. Pharmacol. | pmid:11428663 |
| Esteves MA et al. | Synthetic derivatives of abietic acid with radical scavenging activity. | 2001 | J. Nat. Prod. | pmid:11421739 |
| Ohtsu H et al. | Abietane diterpenoids from the cones of Larix kaempferi and their inhibitory effects on Epstein-Barr virus activation. | 2001 | Planta Med. | pmid:11270723 |
| pmid:11260236 | ||||
| Demers PA et al. | Exposure to dust, resin acids, and monoterpenes in softwood lumber mills. | 2000 Jul-Aug | AIHAJ | pmid:10976682 |
| Fâhraeus-Van Ree GE and Payne JF | Enzyme cytochemical responses of mussels (Mytilus edulis) to resin acid constituents of pulp mill effluents. | 1999 | Bull Environ Contam Toxicol | pmid:10501718 |
| Gardner DR et al. | Ponderosa pine and broom snakeweed: poisonous plants that affect livestock. | 1999 | J Nat Toxins | pmid:10091125 |
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