| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ear Diseases | D004427 | 7 associated lipids |
| Edema | D004487 | 152 associated lipids |
Total
2
Glycyrrhetinic acid
Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.
Cross Reference
Introduction
To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Glycyrrhetinic acid?
Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid
PubChem Associated disorders and diseases
What pathways are associated with Glycyrrhetinic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Glycyrrhetinic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Glycyrrhetinic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Downs SM | A gap-junction-mediated signal, rather than an external paracrine factor, predominates during meiotic induction in isolated mouse oocytes. | 2001 | Zygote | pmid:11273034 |
| Zhang QS et al. | [Targeted glycyrrhetinic acid to receptors of hepatic stellate cells for the treatment of rat liver fibrosis: a pilot study]. | 2004 | Zhonghua Gan Zang Bing Za Zhi | pmid:15329226 |
| Zhang QS et al. | [Targeting glycyrrhetinic acid to hepatic stellate cells in treating rat liver fibrosis]. | 2005 | Zhonghua Gan Zang Bing Za Zhi | pmid:16174454 |
| Zhang Q et al. | [Effects of glycyrrhetinic acid and IFN-alpha on HSCs collagen metabolism in rat fibrotic liver of varying stages]. | 2002 | Zhonghua Gan Zang Bing Za Zhi | pmid:11856516 |
| Zhang Z et al. | [Effect of drug processing on shaoyao gancao decoction]. | 1991 | Zhongguo Zhong Yao Za Zhi | pmid:1910504 |
| Sun X et al. | [Extraction technology of effervescent granules for arresting cold pain optimized by orthogonal tests]. | 1996 | Zhongguo Zhong Yao Za Zhi | pmid:9206256 |
| Yang J et al. | [Determination of glycyrrhetinic acid in radix Glycyrrhizae by TLC densitometry]. | 1991 | Zhongguo Zhong Yao Za Zhi | pmid:1863336 |
| Mao SJ et al. | [Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15139140 |
| Wei SL et al. | [Studies on the shade-endurance capacity of Glycyrrhiza uralensis]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15714809 |
| Wang S et al. | [Dermatopharmacokinetic studies of liangfu cream in mice skin]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21137331 |
| Lu Y et al. | [Study on pharmacokinetics of glycyrrhetic acid in rats by RP-HPLC]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18831211 |
| Cui QH et al. | [Preparation of coated tablets of glycyrrhetic acid-HP-beta-cyclodextrin tablets for colon-specific release]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19157122 |
| Wang S et al. | [Effects of penetration enhancers on in vitro percutaneous absorption and amount retained in skin of paeonol, dictamnine, fraxinellone and glycyrrhetinic acid in Liangfu cream]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19894505 |
| Zhang L and Chang Y | [Effect of decoction of turtle shell for anti-fibrosis combined with stronger neo-minophagen C on indices of hepatic fibrosis in chronic hepatitis B]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22737864 |
| Li X et al. | [Effect of sodium 18 beta-glycyrrhetate on experimental arrhythmia]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1418542 |
| Sun X et al. | [Comparison of constituents extracted from prepared Licorice by semi-bionic extraction with those by water extraction]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205898 |
| Cao S et al. | [Effect of oral administration of glycyrrhetinic acid on six metal elements in rat serum]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22667150 |
| Gao Z et al. | [Research progress of anticancer mechanism of glycyrrhetinic acid]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22375411 |
| Sun X et al. | [Quality standards of effervescent granules for the treatment of cold pain]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:7626205 |
| Zhao S et al. | [Protective effect of Glycyrrhiza uralensis Fisch and its extracts on the chronic desensitization of beta-adrenoceptors in guinea pigs]. | 1991 | Zhongguo Zhong Yao Za Zhi | pmid:1664726 |
| Zhang Z et al. | [Comparison of two extraction methods for maxingshigan decoction]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038900 |
| Zhang JL et al. | [Effect of glycyrrhetinic acid on invasive capacity of leukemic cells and activity of gelatinase]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19123328 |
| Yang JY et al. | [Effects of glycyrrhetinic acid on sodium ion channel currents of rats' ventricular myocardial cells]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:23019953 |
| Wang HL et al. | [Effects of glycyrrihizic acid and prednisone on pathological and ultrastructural changes of kidney in rats with chronic aristolochic acid nephropathy]. | 2007 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17302064 |
| Zhong H et al. | [Roles of gap junctions in proliferation mediated by Hcy in the spontaneous hypertensive rat vascular smooth muscle cells]. | 2012 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:23156716 |
| Chen XY et al. | [The effect of 18beta-glycyrrhetinic acid on gap junction among cerebral arteriolar smooth muscle cells in Wistar rat and spontaneously hypertensive rat]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:23940961 |
| Li SN et al. | Effect of Connexin43 on Mechanical Tension-stimulated Osteogenic Transcription Factors of Human Periodontal Ligament Fibroblasts. | 2016 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:26956851 |
| Bao JF et al. | Effect of sodium glycyrrhetinate on chemical peritonitis in rats. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072951 |
| Zhang HQ et al. | [Anti-allergic action of glycyrrhizin]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2946161 |
| Wu YJ and Li XF | [Effects of sodium 18 beta-glycrrhetinic acid on the production of active oxygen species and the concentration of intracellular free Ca2+ in rat neutrophils]. | 1991 | Zhongguo Yao Li Xue Bao | pmid:1781295 |
| Ju HS et al. | [Scavenging effects of sodium ferulate and 18 beta-glycyrrhetic acid on oxygen free radicals]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:1966652 |
| Wu XM et al. | [Therapeutic effects of epimeric glycyrrhizic acids on hepatic injury in rats]. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1456065 |
| Tao Y et al. | [Expression of 11β-hydroxysteroid dehydrogenase type 2 in lymphoblastic cells and its relationship with glucocorticoid sensitivity]. | 2011 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:21362233 |
| Xu SM et al. | [Glycyrrhetinic acid induces apoptosis and alters survivin gene expression in human myeloma cell line U266]. | 2011 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:21729543 |
| Liu ZJ et al. | Effects of 11beta-hydroxysteroid dehydrogenase inhibitor on body weight and glucose tolerance in Sprague-Dawley rats fed with a high-fat diet. | 2007 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:17582250 |
| Wang D | [Effect of licorzine on extracorporeal fibroblast culture]. | 1990 | Zhong Xi Yi Jie He Za Zhi | pmid:2379301 |
| Ma KF et al. | [Protective effects of triterpenoids on primarily cultured rat hepatocytes injured by D-galactosamine and carbon tetrachloride]. | 2007 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:17571307 |
| Baas EU et al. | [Behavior of gastrin, renin, aldosterone and electrolytes after administration of deglycyrrhizinized liquorice and carbenoxolone in healthy subjects]. | 1976 | Z Gastroenterol | pmid:802922 |
| Zhang XY et al. | [Study on the determination of zinc in plasma after oral administration of licorzin by atomic absorption spectrophotometry and the pharmacokinetics of zinc in healthy volunteers]. | 1990 | Yao Xue Xue Bao | pmid:2239325 |
| Chen XG and Han R | [Effect of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo (a) pyrene]. | 1994 | Yao Xue Xue Bao | pmid:7871996 |
| Liu L et al. | In vitro metabolism of glycyrrhetic acid by human cytochrome P450. | 2011 | Yao Xue Xue Bao | pmid:21462897 |
| Shu YH et al. | [Isolation and structure determination of new triterpene sapogenins from Glycyrrhiza uralensis Fisch]. | 1987 | Yao Xue Xue Bao | pmid:3450150 |
| Abulizi M et al. | [Synthesis and in vitro antioxidant activity of homo- and heterocyclic diene derivatives of glycyrrhetol]. | 2008 | Yao Xue Xue Bao | pmid:18819475 |
| Sun HY et al. | Pharmacokinetic analysis of alpha and beta epimers of glycyrrhetinic acid in rat plasma: differences in singly and combined administrations. | 2012 | Yao Xue Xue Bao | pmid:22493812 |
| Xing PP et al. | Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo. | 2011 | Yao Xue Xue Bao | pmid:21800547 |
| Itoh M et al. | [Quantitative analysis of glycyrrhizin and glycyrrhetinic acid in plasma after administration of FM-100 by using gas chromatography-selected ion monitoring]. | 1985 | Yakugaku Zasshi | pmid:3831322 |
| Zhao X et al. | Sensitive liquid chromatographic assay for the simultaneous determination of ibuprofen and its prodrug, ibuprofen eugenol ester, in rat plasma. | 2005 | Yakugaku Zasshi | pmid:16141693 |
| Odaka A et al. | [Effect of beta-glycyrrhizinate on eye mucosa absorption of drugs]. | 1999 | Yakugaku Zasshi | pmid:10434802 |
| Yasuda K et al. | [Simultaneous determination of glycyrrhizin and glycyrrhetic acid in plasma by high speed liquid chromatography (author's transl)]. | 1978 | Yakugaku Zasshi | pmid:739396 |
| Gui M et al. | [Effect of glycyrrhetinic acid on the expression of inflammatory factors in fibroblast-like synovial cells from collagen induced arthritis rats]. | 2012 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:22980653 |
| Wen J et al. | Comparative pharmacokinetic study of four major components after oral administration of pure compounds, herbs and Si-Ni-San to rats. | 2014 | Xenobiotica | pmid:24641106 |
| Yang BS et al. | Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure. | 2007 | World J. Gastroenterol. | pmid:17230620 |
| Du QH et al. | Glytan decreases portal pressure via mesentery vasoconstriction in portal hypertensive rats. | 2014 | World J. Gastroenterol. | pmid:25469036 |
| Wang JY et al. | Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats. | 2001 | World J. Gastroenterol. | pmid:11819745 |
| Guo XL et al. | Glycyrrhizic acid attenuates CClâ‚„-induced hepatocyte apoptosis in rats via a p53-mediated pathway. | 2013 | World J. Gastroenterol. | pmid:23840116 |
| Rino Y et al. | Does herbal medicine reduce the risk of hepatocellular carcinoma? | 2015 | World J. Gastroenterol. | pmid:26457019 |
| Jones FA and Hunt T | Drugs for peptic ulcer. | 1979 | World J Surg | pmid:516781 |
| Puchner A et al. | Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis. | 2012 | Wien. Klin. Wochenschr. | pmid:22210441 |
| Chamberlain JJ and Abolnik IZ | Pulmonary edema following a licorice binge. | 1997 | West. J. Med. | pmid:9308417 |
| Liu C et al. | [Immunological study on the antitumor effects of fungus polysaccharides compounds]. | 2000 | Wei Sheng Yan Jiu | pmid:12725070 |
| Brailski Kh et al. | [Treatment of stomach ulcer with the Bulgarian preparation Farmaxolon]. | 1987 | Vutr Boles | pmid:3303693 |
| Brailski Kh and Dimitrov B | [Treatment of peptic ulcer with Biogastrone (carbenoxolone)]. | 1979 | Vutr Boles | pmid:516651 |
| Vasilenko AIu et al. | [Use of glycyram on cholelithiasis patients]. | 1986 | Vrach Delo | pmid:3705563 |
| Razina TG et al. | [Glyciram as an enhancer of the effectiveness of chemotherapy and surgery in the treatment of experimental neoplasms]. | 1999 | Vopr Onkol | pmid:10629717 |
| Starokozhko LE et al. | [Effect of cocktails of different gaseous composition containing preparations of licorice root on hemopoiesis and immunity of animals]. | 2003 Jan-Feb | Vopr Kurortol Fizioter Lech Fiz Kult | pmid:12698707 |
| Pan F et al. | Screening of gap junction antagonists on dye coupling in the rabbit retina. | 2007 Jul-Aug | Vis. Neurosci. | pmid:17711600 |
| Xia Y and Nawy S | The gap junction blockers carbenoxolone and 18beta-glycyrrhetinic acid antagonize cone-driven light responses in the mouse retina. | 2003 Jul-Aug | Vis. Neurosci. | pmid:14658771 |
| Knabb MT et al. | Herpes simplex virus-type 2 infectivity and agents that block gap junctional intercellular communication. | 2007 | Virus Res. | pmid:17157406 |
| Hardy ME et al. | 18β-glycyrrhetinic acid inhibits rotavirus replication in culture. | 2012 | Virol. J. | pmid:22616823 |
| Shaneyfelt ME et al. | Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay. | 2006 | Virol. J. | pmid:16948846 |
| Velasquez Almonacid LA et al. | Role of connexin-43 hemichannels in the pathogenesis of Yersinia enterocolitica. | 2009 | Vet. J. | pmid:18824377 |
| [Estimation of efficacy of Hexalyse used for the treatment of acute pharyngitis]. | 2011 | Vestn. Otorinolaringol. | pmid:22433705 | |
| Shakhnes IE | [Use of glycyram in the treatment of dermatoses]. | 1983 | Vestn Dermatol Venerol | pmid:6367265 |
| Chebotarev VV | [Effectiveness of topical application of a new corticoid-like preparation]. | 1981 | Vestn Dermatol Venerol | pmid:7257602 |
| Mel'nikova VS and Karagezian KM | [Dynamics of the histomorphological skin changes in guinea pigs with contact dermatitis under glycyrrhetic acid and prednisolone treatment]. | 1980 | Vestn Dermatol Venerol | pmid:7376714 |
| McNeish AJ et al. | Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat. | 2010 Sep-Oct | Vascul. Pharmacol. | pmid:20601125 |
| Zhao X et al. | Immunological adjuvant efficacy of glycyrrhetinic acid liposome against Newcastle disease vaccine. | 2011 | Vaccine | pmid:22044741 |
| Kim SJ et al. | Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats. | 2011 | Urology | pmid:21820587 |
| Pantazopoulos D et al. | Effect of drugs on crystal adhesion to injured urothelium. | 1990 | Urology | pmid:1697434 |
| Nielsen ML et al. | [Liquorice-induced hypertension and hypokalaemia]. | 2012 | Ugeskr. Laeg. | pmid:22487411 |
| Maser E | Significance of reductases in the detoxification of the tobacco-specific carcinogen NNK. | 2004 | Trends Pharmacol. Sci. | pmid:15120485 |
| Nabekura T | Overcoming multidrug resistance in human cancer cells by natural compounds. | 2010 | Toxins (Basel) | pmid:22069634 |
| Yadav VR et al. | Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. | 2010 | Toxins (Basel) | pmid:22069560 |
| Schrader KK | Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus). | 2010 | Toxins (Basel) | pmid:22069655 |
| Kumar MS et al. | LC-MS/MS as a tool for identification of bioactive compounds in marine sponge Spongosorites halichondriodes (Dendy 1905). | 2012 | Toxicon | pmid:22910370 |
| Lin G et al. | The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats. | 1999 | Toxicon | pmid:10400287 |
| Lee E et al. | Selective release of glutathione transferase subunits from primary cultured rat hepatocytes by carbon tetrachloride and deoxycholic acid. | 1991 | Toxicology | pmid:2048128 |
| Meng Q et al. | Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. | 2007 | Toxicol. Lett. | pmid:17166674 |
| Yu T et al. | Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: potential involvement of H-Ras downregulation. | 2010 | Toxicol. Lett. | pmid:19958823 |
| Ploeger BA et al. | Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10652246 |
| Li X et al. | Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24380838 |
| Shaikh ZA et al. | Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. | 1999 | Toxicol. Appl. Pharmacol. | pmid:9931285 |
| Ploeger B et al. | A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11141355 |
| Jayasooriya RG et al. | 18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway. | 2014 | Toxicol In Vitro | pmid:24613819 |
| Komoda Y | [Nuclear magnetic resonance spectra of 18-beta-glycyrrhetinic acid and its related compounds]. | 1984 | Tokyo Ika Shika Daigaku Iyo Kizai Kenkyusho Hokoku | pmid:6598495 |
| Takeda H et al. | Eosinophilic peritonitis responding to treatment with glycyrrhizin. | 1991 | Tokai J. Exp. Clin. Med. | pmid:1811351 |
| Numazaki K et al. | Effect of glycyrrhizin in children with liver dysfunction associated with cytomegalovirus infection. | 1994 | Tohoku J. Exp. Med. | pmid:8073426 |
| Mori K et al. | Effects of glycyrrhizin (SNMC: Stronger Neo-Minophagen C) in hemophilia patients with HIV-1 infection. | 1990 | Tohoku J. Exp. Med. | pmid:2129071 |
| Shamsa F et al. | The in vitro effects of glycyrrhizin and the derivatives of glycyrrhetinic acid on the activity of cAMP-dependent protein kinase and phosphorylation of cellular polypeptide by the kinase from Ehrlich ascites tumor cells. | 1991 | Tohoku J. Exp. Med. | pmid:1818438 |
| Mori K et al. | Effects of glycyrrhizin (SNMC: stronger Neo-Minophagen C) in hemophilia patients with HIV infection. | 1989 | Tohoku J. Exp. Med. | pmid:2781539 |