Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

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Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycyrrhetinic acid?

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What functions are associated with Glycyrrhetinic acid?


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What lipids are associated with Glycyrrhetinic acid?

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What genes are associated with Glycyrrhetinic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Coutinho AE et al. 11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice. 2012 Endocrinology pmid:22067318
Zhao X et al. Optimization on condition of glycyrrhetinic acid liposome by RSM and the research of its immunological activity. 2012 Int. J. Biol. Macromol. pmid:22584079
Matsumoto T et al. The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells. 2012 Eur. J. Pharmacol. pmid:22542662
Nielsen ML et al. [Liquorice-induced hypertension and hypokalaemia]. 2012 Ugeskr. Laeg. pmid:22487411
Shahidullah M et al. TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. 2012 Am. J. Physiol., Cell Physiol. pmid:22492652
Sun HY et al. Pharmacokinetic analysis of alpha and beta epimers of glycyrrhetinic acid in rat plasma: differences in singly and combined administrations. 2012 Yao Xue Xue Bao pmid:22493812
Cao S et al. [Effect of oral administration of glycyrrhetinic acid on six metal elements in rat serum]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22667150
Alderman SL and Vijayan MM 11β-Hydroxysteroid dehydrogenase type 2 in zebrafish brain: a functional role in hypothalamus-pituitary-interrenal axis regulation. 2012 J. Endocrinol. pmid:23042946
Yang JY et al. [Effects of glycyrrhetinic acid on sodium ion channel currents of rats' ventricular myocardial cells]. 2012 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:23019953
Shi Q et al. Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. 2012 PLoS ONE pmid:23028680