Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

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Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycyrrhetinic acid?

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What functions are associated with Glycyrrhetinic acid?


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What lipids are associated with Glycyrrhetinic acid?

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What genes are associated with Glycyrrhetinic acid?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Moon A and Kim SH Effect of Glycyrrhiza glabra roots and glycyrrhizin on the glucuronidation in rats. 1997 Planta Med. pmid:9140223
Benediktsson R et al. Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. 1997 Clin. Endocrinol. (Oxf) pmid:9135697
Utsunomiya T et al. Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus. 1997 Antimicrob. Agents Chemother. pmid:9055991
Sauerwein HP [3 patients with Addison's disease]. 1977 Ned Tijdschr Geneeskd pmid:904701
Lo YH et al. Kidney 11 beta-HSD2 is inhibited by glycyrrhetinic acid-like factors in human urine. 1997 Hypertension pmid:9039149
Kroes BH et al. Inhibition of human complement by beta-glycyrrhetinic acid. 1997 Immunology pmid:9038721
Seelen MA et al. [Hypertension caused by licorice consumption]. 1996 Ned Tijdschr Geneeskd pmid:9026743
Zakirov UB and Abdullaev AKh [The hypolipidemic and antiatherosclerotic properties of the ammonium salt of glycyrrhetic acid and of 18-dehydroglycyrrhetic acid]. 1996 Sep-Oct Eksp Klin Farmakol pmid:9026213
Frame MK and de Feijter AW Propagation of mechanically induced intercellular calcium waves via gap junctions and ATP receptors in rat liver epithelial cells. 1997 Exp. Cell Res. pmid:9024779
Morishima N and Mori Y Synthesis of glycyrrhizin analogues containing fluorinated beta(1-->2)-linked disaccharides. 1996 Bioorg. Med. Chem. pmid:9007265