Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

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Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycyrrhetinic acid?

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What functions are associated with Glycyrrhetinic acid?


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What lipids are associated with Glycyrrhetinic acid?

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What genes are associated with Glycyrrhetinic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Kuang P et al. 18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice. 2013 Int. J. Cancer pmid:22991231
Dygai AM et al. Comparison of specific activity of granulocytopoiesis stimulators after treatment with cytostatics with different mechanisms of action. 2013 Bull. Exp. Biol. Med. pmid:24288726
Li N et al. Simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma by LC-MS-MS and application to a pharmacokinetic study of Oldenlandia diffusa extract in rats. 2012 Nov-Dec J Chromatogr Sci pmid:22718742
Li J et al. The anti-tumor performance of docetaxel liposomes surface-modified with glycyrrhetinic acid. 2012 J Drug Target pmid:22577855
Nafisi S et al. Interaction of glycyrrhizin and glycyrrhetinic acid with DNA. 2012 DNA Cell Biol. pmid:22074129
Mu Y et al. Visual input modulates audiomotor function via hypothalamic dopaminergic neurons through a cooperative mechanism. 2012 Neuron pmid:22920259
Gui M et al. [Effect of glycyrrhetinic acid on the expression of inflammatory factors in fibroblast-like synovial cells from collagen induced arthritis rats]. 2012 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:22980653
Behringer EJ et al. Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives. 2012 Br. J. Pharmacol. pmid:22168386
Zhang C et al. Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy. 2012 Biomaterials pmid:22169820
Li S et al. A novel transdermal fomulation of 18β-glycyrrhetic acid with lysine for improving bioavailability and efficacy. 2012 Skin Pharmacol Physiol pmid:22832704