Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

Cross Reference

Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Glycyrrhetinic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Glycyrrhetinic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Glycyrrhetinic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Glycyrrhetinic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

Download all related citations
Per page 10 20 50 100 | Total 1459
Authors Title Published Journal PubMed Link
Guo BH et al. HPLC assay and pharmacokinetics and tissue distribution study of glycyrrhetinic acid liposomes modified with galactosylated lipid. 2012 J Liposome Res pmid:22313057
Ishida T et al. Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities. 2012 Evid Based Complement Alternat Med pmid:21785649
Nafisi S et al. Study on the interaction of glycyrrhizin and glycyrrhetinic acid with RNA. 2012 J. Photochem. Photobiol. B, Biol. pmid:22513095
Tabuchi M et al. The blood-brain barrier permeability of 18β-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan. 2012 Cell. Mol. Neurobiol. pmid:22488528
Wang LJ et al. Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents. 2012 Bioorg. Med. Chem. Lett. pmid:22520261
Couteau C et al. Influence of certain ingredients on the SPF determined in vivo. 2012 Arch. Dermatol. Res. pmid:22707250
Wang XH et al. In vitro evaluation of polymeric micelles based on hydrophobically-modified sulfated chitosan as a carrier of doxorubicin. 2012 J Mater Sci Mater Med pmid:22538726
Csuk R et al. Conversions at C-30 of glycyrrhetinic acid and their impact on antitumor activity. 2012 Arch. Pharm. (Weinheim) pmid:21997717
Niger C et al. ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. 2012 Am. J. Physiol., Cell Physiol. pmid:22277757
Kumar MS et al. LC-MS/MS as a tool for identification of bioactive compounds in marine sponge Spongosorites halichondriodes (Dendy 1905). 2012 Toxicon pmid:22910370
Cao S et al. [Effect of oral administration of glycyrrhetinic acid on six metal elements in rat serum]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22667150
Li L et al. Myoendothelial coupling is unidirectional in guinea pig spiral modiolar arteries. 2012 Microvasc. Res. pmid:22580342
Gao J et al. Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities. 2012 Bioorg. Med. Chem. Lett. pmid:22406153
Yang JC et al. 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. 2012 Mol. Cell. Biochem. pmid:22865487
Yokokawa A et al. The effect of water loading on the urinary ratio of cortisone to cortisol in healthy subjects and a new approach to the evaluation of the ratio as an index for in vivo human 11β-hydroxysteroid dehydrogenase 2 activity. 2012 Steroids pmid:22850318
Pirraco RP et al. Fibroblasts regulate osteoblasts through gap junctional communication. 2012 Cytotherapy pmid:22853696
Wen J et al. UPLC-MS/MS determination of paeoniflorin, naringin, naringenin and glycyrrhetinic acid in rat plasma and its application to a pharmacokinetic study after oral administration of Si-Ni-San decoction. 2012 J Pharm Biomed Anal pmid:22521636
Liu Y et al. Study on the noncovalent interactions of saikosaponins and cytochrome c by electrospray ionization mass spectrometry. 2012 Rapid Commun. Mass Spectrom. pmid:22368050
Sharma G et al. 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. 2012 J. Cell. Physiol. pmid:21732363
Guo BH et al. Preparation and characterization of galactose-modified liposomes by a nonaqueous enzymatic reaction. 2011 J Liposome Res pmid:21545336
Haddock RE et al. Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms. 2011 PLoS ONE pmid:21283658
Li XL et al. Antioxidant status and immune activity of glycyrrhizin in allergic rhinitis mice. 2011 Int J Mol Sci pmid:21541033
Witkamp RF Current and future drug targets in weight management. 2011 Pharm. Res. pmid:21181547
Wyrwoll CS et al. 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. 2011 Front Neuroendocrinol pmid:21144857
Csuk R et al. Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives. 2011 Eur J Med Chem pmid:21959232
Lin KW et al. 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. 2011 Bioorg. Med. Chem. pmid:21696969
Badr AE et al. A laboratory evaluation of the antibacterial and cytotoxic effect of Liquorice when used as root canal medicament. 2011 Int Endod J pmid:20812941
Popovich DG et al. Ginseng (Panax quinquefolius) and Licorice (Glycyrrhiza uralensis) Root Extract Combinations Increase Hepatocarcinoma Cell (Hep-G2) Viability. 2011 Evid Based Complement Alternat Med pmid:19617200
Takeuchi H et al. Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. 2011 PLoS ONE pmid:21712989
Piao H et al. Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys. 2011 Clin. Exp. Nephrol. pmid:21153751
Scott LM et al. Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs. 2011 Bioorg. Med. Chem. Lett. pmid:21193311
Kong X et al. Roles of phytochemicals in amino acid nutrition. 2011 Front Biosci (Schol Ed) pmid:21196382
Sasseville D et al. Allergic contact dermatitis caused by glycyrrhetinic acid and castor oil. 2011 Contact Derm. pmid:21272025
Kim SJ et al. Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats. 2011 Urology pmid:21820587
Wang CY et al. Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. 2011 J. Agric. Food Chem. pmid:21644799
Delacour H et al. [The old man and the syrup]. 2011 Pathol. Biol. pmid:19896293
Ma KT et al. [18β-glycyrrhetinic acid inhibits outward current of vascular smooth muscle cells of arterioles]. 2011 Sheng Li Xue Bao pmid:22193450
Ukil A et al. Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases. 2011 PLoS ONE pmid:22194991
Zhang C et al. Antitumor activity of drug loaded glycyrrhetinic acid modified alginate nanoparticles on mice bearing orthotopic liver tumor. 2011 J Control Release pmid:22195787
Tian Q et al. Understanding the role of the C3-hydroxyl group in glycyrrhetinic acid on liver targeting. 2011 J Control Release pmid:22195881
Kowsalya R et al. Chemopreventive potential of 18beta-glycyrrhetinic acid: an active constituent of liquorice, in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. 2011 Pak. J. Biol. Sci. pmid:22235502
Upur H et al. Inhibition of Cell Growth and Cellular Protein, DNA and RNA Synthesis in Human Hepatoma (HepG2) Cells by Ethanol Extract of Abnormal Savda Munziq of Traditional Uighur Medicine. 2011 Evid Based Complement Alternat Med pmid:18955370
Veratti E et al. 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. 2011 Anticancer Res. pmid:21737643
Chen Q et al. Identification and quantification of oleanolic acid and ursolic acid in Chinese herbs by liquid chromatography-ion trap mass spectrometry. 2011 Biomed. Chromatogr. pmid:21465498
Akasaka Y et al. Glycyrrhetinic acid prevents cutaneous scratching behavior in mice elicited by substance P or PAR-2 agonist. 2011 Eur. J. Pharmacol. pmid:21925497
Tao Y et al. [Expression of 11β-hydroxysteroid dehydrogenase type 2 in lymphoblastic cells and its relationship with glucocorticoid sensitivity]. 2011 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:21362233
Logashenko EB et al. Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives. 2011 Chembiochem pmid:21328513
Matsuzaki Y et al. [Alternative therapies for hepatitis C: UDCA and SNMC]. 2011 Nippon Rinsho pmid:22096928
Zhao X et al. Immunological adjuvant efficacy of glycyrrhetinic acid liposome against Newcastle disease vaccine. 2011 Vaccine pmid:22044741
Jeong HJ et al. C-kit binding properties of hesperidin (a major component of KMP6) as a potential anti-allergic agent. 2011 PLoS ONE pmid:21559359