Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

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Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycyrrhetinic acid?

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What functions are associated with Glycyrrhetinic acid?


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What lipids are associated with Glycyrrhetinic acid?

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What genes are associated with Glycyrrhetinic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Miyakawa Y and Iino S Toward prevention of hepatocellular carcinoma developing in chronic hepatitis C. 2001 J. Gastroenterol. Hepatol. pmid:11446875
van Rossum TG et al. 'Pseudo-aldosteronism' induced by intravenous glycyrrhizin treatment of chronic hepatitis C patients. 2001 J. Gastroenterol. Hepatol. pmid:11446888
Verderio C et al. Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes. 2001 J. Neurochem. pmid:11483668
Sigurjónsdóttir HA L et al. Liquorice-induced rise in blood pressure: a linear dose-response relationship. 2001 J Hum Hypertens pmid:11494093
Ploeger B et al. The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. 2001 Drug Metab. Rev. pmid:11495500
Romanello M and D'Andrea P Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels. 2001 J. Bone Miner. Res. pmid:11499869
Sakamoto R et al. Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro. 2001 Biol. Pharm. Bull. pmid:11510483
Böhmer C et al. 18-beta-Glycyrrhetinic acid (BGA) as an electrical uncoupler for intracellular recordings in confluent monolayer cultures. 2001 Pflugers Arch. pmid:11512024
Tabernero A et al. The enhancement of glucose uptake caused by the collapse of gap junction communication is due to an increase in astrocyte proliferation. 2001 J. Neurochem. pmid:11520909
Shimoyama Y et al. Characterization of secretory type IIA phospholipase A2 (sPLA2-IIA) as a glycyrrhizin (GL)-binding protein and the GL-induced inhibition of the CK-II-mediated stimulation of sPLA2-IIA activity in vitro. 2001 Biol. Pharm. Bull. pmid:11558558