Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

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Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycyrrhetinic acid?

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What functions are associated with Glycyrrhetinic acid?


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What lipids are associated with Glycyrrhetinic acid?

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What genes are associated with Glycyrrhetinic acid?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Hung CF et al. 18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. 2017 PLoS ONE pmid:28813533
Lv Y et al. Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier. 2017 Int J Nanomedicine pmid:28652738
Zhang Y et al. REDUCING TOXICITY AND INCREASING EFFICIENCY: ACONITINE WITH LIQUIRITIN AND GLYCYRRHETINIC ACID REGULATE CALCIUM REGULATORY PROTEINS IN RAT MYOCARDIAL CELL. 2017 Afr J Tradit Complement Altern Med pmid:28638869
Suswillo RF et al. Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. 2017 Cell Biochem. Funct. pmid:28083967
Chen J et al. Glycyrrhetinic acid alleviates radiation-induced lung injury in mice. 2017 J. Radiat. Res. pmid:27672101
Du H et al. Insight into the role of dual-ligand modification in low molecular weight heparin based nanocarrier for targeted delivery of doxorubicin. 2017 Int J Pharm pmid:28359815
Ji B et al. Development and validation of a sensitive and fast UPLC-MS/MS method for simultaneous determination of seven bioactive compounds in rat plasma after oral administration of Guizhi-gancao decoction. 2017 J Pharm Biomed Anal pmid:28088663
Wang J et al. Pharmacokinetics study of Erhuang decoction extracts in rats by HPLC-MS/MS. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:28570935
Yan G et al. Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin. 2016 Artif Cells Nanomed Biotechnol pmid:25287740
Zhu Y et al. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. 2016 Cell Metab. pmid:27626200
Queiroga CS et al. Paracrine effect of carbon monoxide - astrocytes promote neuroprotection through purinergic signaling in mice. 2016 J. Cell. Sci. pmid:27383770
Huang YC et al. 18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways. 2016 Molecules pmid:27376261
Ikarashi Y and Mizoguchi K Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. 2016 Pharmacol. Ther. pmid:27373856
Jeon YD et al. Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo. 2016 Molecules pmid:27110761
Yu J et al. Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal. 2016 Endocrinology pmid:27035651
Cao D et al. The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils. 2016 Biomed Res Int pmid:27006947
Li SN et al. Effect of Connexin43 on Mechanical Tension-stimulated Osteogenic Transcription Factors of Human Periodontal Ligament Fibroblasts. 2016 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:26956851
Cong Y et al. One-step Conjugation of Glycyrrhetinic Acid to Cationic Polymers for High-performance Gene Delivery to Cultured Liver Cell. 2016 Sci Rep pmid:26902258
Papaevgeniou N et al. 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. 2016 Antioxid. Redox Signal. pmid:26886723
Wang FZ et al. Codelivery of Doxorubicin and shAkt1 by Poly(ethylenimine)-Glycyrrhetinic Acid Nanoparticles To Induce Autophagy-Mediated Liver Cancer Combination Therapy. 2016 Mol. Pharm. pmid:26894988