Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

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Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycyrrhetinic acid?

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What functions are associated with Glycyrrhetinic acid?


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What lipids are associated with Glycyrrhetinic acid?

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What genes are associated with Glycyrrhetinic acid?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
Lin J et al. Development of Salvianolic acid B-Tanshinone II A-Glycyrrhetinic acid compound liposomes: formulation optimization and its effects on proliferation of hepatic stellate cells. 2014 Int J Pharm pmid:24374609
Du QH et al. Glytan decreases portal pressure via mesentery vasoconstriction in portal hypertensive rats. 2014 World J. Gastroenterol. pmid:25469036
Adianti M et al. Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. 2014 Microbiol. Immunol. pmid:24397541
Wen J et al. Comparative pharmacokinetic study of four major components after oral administration of pure compounds, herbs and Si-Ni-San to rats. 2014 Xenobiotica pmid:24641106
Tian J et al. A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects. 2014 Drug Deliv pmid:24215357
Wang D et al. 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. 2014 J. Neurooncol. pmid:24162829
Liu J et al. High-throughput measurement of gap junctional intercellular communication. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:24778169
Song J et al. Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells. 2014 Bioorg. Med. Chem. Lett. pmid:24461294
Jia LL et al. Aggravation of clozapine-induced hepatotoxicity by glycyrrhetinic acid in rats. 2014 J. Pharmacol. Sci. pmid:24739264
Sakata O et al. Effects of oils and emulsifiers on the skin penetration of stearyl glycyrrhetinate in oil-in-water emulsions. 2014 Biol. Pharm. Bull. pmid:24583868