| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
Total
2
Glycyrrhetinic acid
Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.
Cross Reference
Introduction
To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Glycyrrhetinic acid?
Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid
PubChem Associated disorders and diseases
What pathways are associated with Glycyrrhetinic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Glycyrrhetinic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Glycyrrhetinic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Killacky J et al. | The determination of beta-glycyrrhetinic acid in liquorice by high pressure liquid chromatography. | 1976 | Planta Med. | pmid:1005535 |
| Bao JF et al. | Effect of sodium glycyrrhetinate on chemical peritonitis in rats. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072951 |
| Bani-Yaghoub M et al. | The effects of gap junction blockage on neuronal differentiation of human NTera2/clone D1 cells. | 1999 | Exp. Neurol. | pmid:10192774 |
| DygaÄ AM et al. | [The blood-simulating properties of a recombinant colony-stimulating factor and glycyram during cytostatic myelosuppression]. | 1999 Jan-Feb | Eksp Klin Farmakol | pmid:10198763 |
| Nathanson MH et al. | Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. | 1999 | Gastroenterology | pmid:10220510 |
| Steinegger E and Marty S | [Glycyrrhizic acid determination in radix liquiritiae. Comparison of various methods]. | 1976 | Pharm Acta Helv | pmid:1023225 |
| Zakirov NU et al. | [The cardioprotective action of 18-dehydroglycyrrhetic acid in experimental myocardial damage]. | 1999 Mar-Apr | Eksp Klin Farmakol | pmid:10340122 |
| Maser E | The protective role of 11 beta-hydroxysteroid dehydrogenase/carbonyl reductase against tobacco-smoke related lung cancer. | 1999 | Adv. Exp. Med. Biol. | pmid:10352709 |
| Guo Y et al. | Inhibition of gap junction communication in alveolar epithelial cells by 18alpha-glycyrrhetinic acid. | 1999 | Am. J. Physiol. | pmid:10362727 |
| Cameron BD et al. | The absorption of [G-3H]-acetylglycyrrhetate after oral administration to rats. | 1976 | Arzneimittelforschung | pmid:1036700 |
| Lin G et al. | The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats. | 1999 | Toxicon | pmid:10400287 |
| Odaka A et al. | [Effect of beta-glycyrrhizinate on eye mucosa absorption of drugs]. | 1999 | Yakugaku Zasshi | pmid:10434802 |
| Hu WY et al. | The induction of liver microsomal cytochrome P450 by Glycyrrhiza uralensis and glycyrrhetinic acid in mice. | 1999 | Biomed. Environ. Sci. | pmid:10442216 |
| Feinstein MB and Schleimer RP | Regulation of the action of hydrocortisone in airway epithelial cells by 11beta-hydroxysteroid dehydrogenase. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10460758 |
| Griffith TM and Taylor HJ | Cyclic AMP mediates EDHF-type relaxations of rabbit jugular vein. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10486252 |
| Tanaka Y et al. | Glycyrrhetinic acid-sensitive mechanism does not make a major contribution to non-prostanoid, non-nitric oxide mediated endothelium-dependent relaxation of rat mesenteric artery in response to acetylcholine. | 1999 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:10509734 |
| Guillaume CP et al. | Determination of urinary 18 beta-glycyrrhetinic acid by gas chromatography and its clinical application in man. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10510787 |
| Bertuzzi F et al. | Mechanisms of coordination of Ca2+ signals in pancreatic islet cells. | 1999 | Diabetes | pmid:10512361 |
| Horigome H et al. | Glycyrrhetinic acid-induced apoptosis in thymocytes: impact of 11beta-hydroxysteroid dehydrogenase inhibition. | 1999 | Am. J. Physiol. | pmid:10516121 |
| Vance MM and Wiley LM | Gap junction intercellular communication mediates the competitive cell proliferation disadvantage of irradiated mouse preimplantation embryos in aggregation chimeras. | 1999 | Radiat. Res. | pmid:10521932 |
| Chaytor AT et al. | The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. | 1999 | J. Physiol. (Lond.) | pmid:10523421 |
| Fukuta H et al. | Inhibition of the endothelium-dependent relaxation by 18beta-glycyrrhetinic acid in the guinea-pig aorta. | 1999 | Jpn. J. Physiol. | pmid:10529487 |
| Heilmann P et al. | Administration of glycyrrhetinic acid: significant correlation between serum levels and the cortisol/cortisone-ratio in serum and urine. | 1999 | Exp. Clin. Endocrinol. Diabetes | pmid:10543414 |
| Harada S et al. | Casein kinase II (CK-II)-mediated stimulation of HIV-1 reverse transcriptase activity and characterization of selective inhibitors in vitro. | 1999 | Biol. Pharm. Bull. | pmid:10549869 |
| Princen F et al. | A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect. | 1999 | Clin. Cancer Res. | pmid:10589781 |
| Murai T et al. | Levcromakalim causes indirect endothelial hyperpolarization via a myo-endothelial pathway. | 1999 | Br. J. Pharmacol. | pmid:10602328 |
| Rossi T et al. | Correlation between high intake of glycyrrhizin and myolysis of the papillary muscles: an experimental in vivo study. | 1999 | Pharmacol. Toxicol. | pmid:10608484 |
| Fujimoto S et al. | K(+) channel blockers and cytochrome P450 inhibitors on acetylcholine-induced, endothelium-dependent relaxation in rabbit mesenteric artery. | 1999 | Eur. J. Pharmacol. | pmid:10611413 |
| Kerstens MN et al. | Gas chromatographic-mass spectrometric analysis of urinary glycyrrhetinic acid: an aid in diagnosing liquorice abuse. | 1999 | J. Intern. Med. | pmid:10620097 |
| Yu J et al. | Gap junction uncouplers attenuate arteriolar response to distal capillary stimuli. | 2000 | Microvasc. Res. | pmid:10625583 |
| Razina TG et al. | [Glyciram as an enhancer of the effectiveness of chemotherapy and surgery in the treatment of experimental neoplasms]. | 1999 | Vopr Onkol | pmid:10629717 |
| Farioli-Vecchioli S et al. | Inverse expression of peroxisomes and connexin-43 in the granulosa cells of the quail follicle. | 2000 | J. Histochem. Cytochem. | pmid:10639483 |
| Ploeger BA et al. | Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10652246 |
| Santicioli P and Maggi CA | Effect of 18beta-glycyrrhetinic acid on electromechanical coupling in the guinea-pig renal pelvis and ureter. | 2000 | Br. J. Pharmacol. | pmid:10694216 |
| Shim SB et al. | Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid from the rhizomes of Glycyrrhiza uralensis. | 2000 | Planta Med. | pmid:10705732 |
| Iino S | Relationship between infection with hepatitis C virus and hepatocellular carcinoma in Japan. | 1998 | Antivir. Ther. (Lond.) | pmid:10726064 |
| Yamamoto Y et al. | Mitigation of hepato-cellular injury caused by HAART with glycyrrhizin compound in patients co-infected with HIV and HCV. | 1999 | Jpn. J. Infect. Dis. | pmid:10738365 |
| Oviedo-Orta E et al. | Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations. | 2000 | Immunology | pmid:10792506 |
| Amer M and Metwalli M | Topical liquiritin improves melasma. | 2000 | Int. J. Dermatol. | pmid:10809983 |
| Robe PA et al. | Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: effects of dibutyryl adenosine 3',5'-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside. | 2000 | Biochem. Pharmacol. | pmid:10825469 |
| Cohen KD et al. | Remote arteriolar dilations in response to muscle contraction under capillaries. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10843889 |
| White R and Hiley CR | Hyperpolarisation of rat mesenteric endothelial cells by ATP-sensitive K(+) channel openers. | 2000 | Eur. J. Pharmacol. | pmid:10844125 |
| Squires PE et al. | Synchronization of Ca(2+)-signals within insulin-secreting pseudoislets: effects of gap-junctional uncouplers. | 2000 | Cell Calcium | pmid:10859595 |
| Hill CE et al. | Role of gap junctions in acetylcholine-induced vasodilation of proximal and distal arteries of the rat mesentery. | 2000 | J. Auton. Nerv. Syst. | pmid:10869710 |
| Reuss B et al. | Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2. | 2000 | Mol. Cell. Neurosci. | pmid:10882482 |
| D'Andrea P et al. | Intercellular Ca2+ waves in mechanically stimulated articular chondrocytes. | 2000 | Biorheology | pmid:10912180 |
| Johnstone HA et al. | Attenuation of hypothalamic-pituitary-adrenal axis stress responses in late pregnancy: changes in feedforward and feedback mechanisms. | 2000 | J. Neuroendocrinol. | pmid:10929094 |
| Winkler J and Marmé S | Titania as a sorbent in normal-phase liquid chromatography. | 2000 | J Chromatogr A | pmid:10949472 |
| Bannerman P et al. | Early migratory rat neural crest cells express functional gap junctions: evidence that neural crest cell survival requires gap junction function. | 2000 | J. Neurosci. Res. | pmid:10972957 |
| Loty S et al. | Association of enhanced expression of gap junctions with in vitro chondrogenic differentiation of rat nasal septal cartilage-released cells following their dedifferentiation and redifferentiation. | 2000 | Arch. Oral Biol. | pmid:10973558 |
| Levin M and Mercola M | Expression of connexin 30 in Xenopus embryos and its involvement in hatching gland function. | 2000 | Dev. Dyn. | pmid:10974676 |
| Frey FJ and Ferrari P | Pastis and hypertension--what is the molecular basis? | 2000 | Nephrol. Dial. Transplant. | pmid:11007814 |
| Zhang Z et al. | [Comparison of two extraction methods for maxingshigan decoction]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038900 |
| Murrant CL and Sarelius IH | Local and remote arteriolar dilations initiated by skeletal muscle contraction. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11045964 |
| Imaeda K et al. | Hyperpolarization-induced dilatation of submucosal arterioles in the guinea-pig ileum. | 2000 | Br. J. Pharmacol. | pmid:11082119 |
| Zakirov NU et al. | [Cardioprotective effect of glycyram in myocardial damage induced by isadrine]. | 2000 Sep-Oct | Eksp Klin Farmakol | pmid:11109520 |
| Razina TG et al. | [Medicinal plant preparations used as adjuvant therapeutics in experimental oncology]. | 2000 Sep-Oct | Eksp Klin Farmakol | pmid:11109531 |
| Vrolijk JM and Schalm SW | [Hepatitis C in Egypt, a iatrogenic epidemic]. | 2000 | Ned Tijdschr Geneeskd | pmid:11129975 |
| Ploeger B et al. | A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11141355 |
| Doughty JM et al. | Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium. | 2001 | Br. J. Pharmacol. | pmid:11156589 |
| Krazeisen A et al. | Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5. | 2001 | Mol. Cell. Endocrinol. | pmid:11165023 |
| Momose-Sato Y et al. | Spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain: optical evidence for intercellular communication in the developing central nervous system. | 2001 | Neuroscience | pmid:11166111 |
| Horigome H et al. | Glycyrrhetinic acid induced apoptosis in murine splenocytes. | 2001 | Biol. Pharm. Bull. | pmid:11201246 |
| Chaytor AT et al. | Comparison of glycyrrhetinic acid isoforms and carbenoxolone as inhibitors of EDHF-type relaxations mediated via gap junctions. | 2000 | Endothelium | pmid:11201524 |
| Hashitani H et al. | Origin and propagation of spontaneous excitation in smooth muscle of the guinea-pig urinary bladder. | 2001 | J. Physiol. (Lond.) | pmid:11208975 |
| Tanaka S et al. | Allergic contact dermatitis from enoxolone. | 2001 | Contact Derm. | pmid:11218003 |
| Coleman HA et al. | K+ currents underlying the action of endothelium-derived hyperpolarizing factor in guinea-pig, rat and human blood vessels. | 2001 | J. Physiol. (Lond.) | pmid:11230509 |
| Oviedo-Orta E et al. | Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication. | 2001 | FASEB J. | pmid:11259395 |
| Jiang F and Dusting GJ | Endothelium-dependent vasorelaxation independent of nitric oxide and K(+) release in isolated renal arteries of rats. | 2001 | Br. J. Pharmacol. | pmid:11264250 |
| Horigome H et al. | Magnolol from Magnolia officinalis inhibits 11beta-hydroxysteroid dehydrogenase without increases of corticosterone and thymocyte apoptosis in mice. | 2001 | Planta Med. | pmid:11270719 |
| Downs SM | A gap-junction-mediated signal, rather than an external paracrine factor, predominates during meiotic induction in isolated mouse oocytes. | 2001 | Zygote | pmid:11273034 |
| Schiller PC et al. | Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro. | 2001 | J. Biol. Chem. | pmid:11278824 |
| Radwan MA and Aboul-Enein HY | The effect of absorption enhancers on the initial degradation kinetics of insulin by alpha-chymotrypsin. | 2001 | Int J Pharm | pmid:11292547 |
| Schiller PC et al. | Gap-junctional communication is required for the maturation process of osteoblastic cells in culture. | 2001 | Bone | pmid:11336916 |
| Odermatt A et al. | The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2. | 2001 | J. Biol. Chem. | pmid:11350956 |
| Ruiz-Meana M et al. | Persistence of gap junction communication during myocardial ischemia. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356611 |
| Tanigawa K et al. | Characterization of bovine angiogenin-1 and lactogenin-like protein as glycyrrhizin-binding proteins and their in vitro phosphorylation by C-kinase. | 2001 | Biol. Pharm. Bull. | pmid:11379757 |
| Koyama K et al. | Expression of the 11beta-hydroxysteroid dehydrogenase type II enzyme in breast tumors and modulation of activity and cell growth in PMC42 cells. | 2001 Jan-Mar | J. Steroid Biochem. Mol. Biol. | pmid:11384873 |
| Zuo F et al. | Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography. | 2001 | Biol. Pharm. Bull. | pmid:11411561 |
| Miyakawa Y and Iino S | Toward prevention of hepatocellular carcinoma developing in chronic hepatitis C. | 2001 | J. Gastroenterol. Hepatol. | pmid:11446875 |
| van Rossum TG et al. | 'Pseudo-aldosteronism' induced by intravenous glycyrrhizin treatment of chronic hepatitis C patients. | 2001 | J. Gastroenterol. Hepatol. | pmid:11446888 |
| Verderio C et al. | Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes. | 2001 | J. Neurochem. | pmid:11483668 |
| Sigurjónsdóttir HA L et al. | Liquorice-induced rise in blood pressure: a linear dose-response relationship. | 2001 | J Hum Hypertens | pmid:11494093 |
| Ploeger B et al. | The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. | 2001 | Drug Metab. Rev. | pmid:11495500 |
| Romanello M and D'Andrea P | Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels. | 2001 | J. Bone Miner. Res. | pmid:11499869 |
| Sakamoto R et al. | Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro. | 2001 | Biol. Pharm. Bull. | pmid:11510483 |
| Böhmer C et al. | 18-beta-Glycyrrhetinic acid (BGA) as an electrical uncoupler for intracellular recordings in confluent monolayer cultures. | 2001 | Pflugers Arch. | pmid:11512024 |
| Tabernero A et al. | The enhancement of glucose uptake caused by the collapse of gap junction communication is due to an increase in astrocyte proliferation. | 2001 | J. Neurochem. | pmid:11520909 |
| Shimoyama Y et al. | Characterization of secretory type IIA phospholipase A2 (sPLA2-IIA) as a glycyrrhizin (GL)-binding protein and the GL-induced inhibition of the CK-II-mediated stimulation of sPLA2-IIA activity in vitro. | 2001 | Biol. Pharm. Bull. | pmid:11558558 |
| Shah US and Murray SA | Bimodal inhibition of connexin 43 gap junctions decreases ACTH-induced steroidogenesis and increases bovine adrenal cell population growth. | 2001 | J. Endocrinol. | pmid:11572804 |
| Daniel EE et al. | Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle? | 2001 | Neurogastroenterol. Motil. | pmid:11576389 |
| Ballesteros ML et al. | LAF1, a MYB transcription activator for phytochrome A signaling. | 2001 | Genes Dev. | pmid:11581165 |
| Murav'ev IA et al. | [Experimental study of anti-inflammatory and wound healing properties of 1% ointments of 18-dehydroglycyrrhetic acid sodium salt]. | 2001 Jul-Aug | Eksp Klin Farmakol | pmid:11589111 |
| Koyama K and Krozowski Z | Modulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity in Ishikawa cells is associated with changes in cellular proliferation. | 2001 | Mol. Cell. Endocrinol. | pmid:11604236 |
| White R et al. | Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. | 2001 | Br. J. Pharmacol. | pmid:11606334 |
| Singer JH et al. | Potentiation of L-type calcium channels reveals nonsynaptic mechanisms that correlate spontaneous activity in the developing mammalian retina. | 2001 | J. Neurosci. | pmid:11606640 |
| Scotland RS et al. | An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide. | 2001 | Hypertension | pmid:11641295 |
| Akao T | Effect of pH on metabolism of glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid monoglucuronide by collected human intestinal flora. | 2001 | Biol. Pharm. Bull. | pmid:11642312 |
| Okamura N et al. | Simultaneous determination of glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid mono-glucuronide in Shakuyaku-kanzo-to incubated with rat feces by semi-micro high-performance liquid chromatography. | 2001 | Biol. Pharm. Bull. | pmid:11642324 |