Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

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Introduction

To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Glycyrrhetinic acid?

Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid

PubChem Associated disorders and diseases

What pathways are associated with Glycyrrhetinic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Glycyrrhetinic acid?

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What functions are associated with Glycyrrhetinic acid?


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What lipids are associated with Glycyrrhetinic acid?

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What genes are associated with Glycyrrhetinic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Glycyrrhetinic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Glycyrrhetinic acid

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Authors Title Published Journal PubMed Link
pmid:
Killacky J et al. The determination of beta-glycyrrhetinic acid in liquorice by high pressure liquid chromatography. 1976 Planta Med. pmid:1005535
Bao JF et al. Effect of sodium glycyrrhetinate on chemical peritonitis in rats. 1997 Zhongguo Yao Li Xue Bao pmid:10072951
Bani-Yaghoub M et al. The effects of gap junction blockage on neuronal differentiation of human NTera2/clone D1 cells. 1999 Exp. Neurol. pmid:10192774
DygaÄ­ AM et al. [The blood-simulating properties of a recombinant colony-stimulating factor and glycyram during cytostatic myelosuppression]. 1999 Jan-Feb Eksp Klin Farmakol pmid:10198763
Nathanson MH et al. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. 1999 Gastroenterology pmid:10220510
Steinegger E and Marty S [Glycyrrhizic acid determination in radix liquiritiae. Comparison of various methods]. 1976 Pharm Acta Helv pmid:1023225
Zakirov NU et al. [The cardioprotective action of 18-dehydroglycyrrhetic acid in experimental myocardial damage]. 1999 Mar-Apr Eksp Klin Farmakol pmid:10340122
Maser E The protective role of 11 beta-hydroxysteroid dehydrogenase/carbonyl reductase against tobacco-smoke related lung cancer. 1999 Adv. Exp. Med. Biol. pmid:10352709
Guo Y et al. Inhibition of gap junction communication in alveolar epithelial cells by 18alpha-glycyrrhetinic acid. 1999 Am. J. Physiol. pmid:10362727
Cameron BD et al. The absorption of [G-3H]-acetylglycyrrhetate after oral administration to rats. 1976 Arzneimittelforschung pmid:1036700
Lin G et al. The effects of pretreatment with glycyrrhizin and glycyrrhetinic acid on the retrorsine-induced hepatotoxicity in rats. 1999 Toxicon pmid:10400287
Odaka A et al. [Effect of beta-glycyrrhizinate on eye mucosa absorption of drugs]. 1999 Yakugaku Zasshi pmid:10434802
Hu WY et al. The induction of liver microsomal cytochrome P450 by Glycyrrhiza uralensis and glycyrrhetinic acid in mice. 1999 Biomed. Environ. Sci. pmid:10442216
Feinstein MB and Schleimer RP Regulation of the action of hydrocortisone in airway epithelial cells by 11beta-hydroxysteroid dehydrogenase. 1999 Am. J. Respir. Cell Mol. Biol. pmid:10460758
Griffith TM and Taylor HJ Cyclic AMP mediates EDHF-type relaxations of rabbit jugular vein. 1999 Biochem. Biophys. Res. Commun. pmid:10486252
Tanaka Y et al. Glycyrrhetinic acid-sensitive mechanism does not make a major contribution to non-prostanoid, non-nitric oxide mediated endothelium-dependent relaxation of rat mesenteric artery in response to acetylcholine. 1999 Res. Commun. Mol. Pathol. Pharmacol. pmid:10509734
Guillaume CP et al. Determination of urinary 18 beta-glycyrrhetinic acid by gas chromatography and its clinical application in man. 1999 J. Chromatogr. B Biomed. Sci. Appl. pmid:10510787
Bertuzzi F et al. Mechanisms of coordination of Ca2+ signals in pancreatic islet cells. 1999 Diabetes pmid:10512361
Horigome H et al. Glycyrrhetinic acid-induced apoptosis in thymocytes: impact of 11beta-hydroxysteroid dehydrogenase inhibition. 1999 Am. J. Physiol. pmid:10516121