| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
Total
2
Glycyrrhetinic acid
Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.
Cross Reference
Introduction
To understand associated biological information of Glycyrrhetinic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Glycyrrhetinic acid?
Glycyrrhetinic acid is suspected in Hypertensive disease, Kozlowski Celermajer Tink syndrome, Hypernatremia, Leishmaniasis, Visceral, Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Glycyrrhetinic acid
PubChem Associated disorders and diseases
What pathways are associated with Glycyrrhetinic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Glycyrrhetinic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Glycyrrhetinic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Glycyrrhetinic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Glycyrrhetinic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hung CF et al. | 18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. | 2017 | PLoS ONE | pmid:28813533 |
| Lv Y et al. | Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier. | 2017 | Int J Nanomedicine | pmid:28652738 |
| Zhang Y et al. | REDUCING TOXICITY AND INCREASING EFFICIENCY: ACONITINE WITH LIQUIRITIN AND GLYCYRRHETINIC ACID REGULATE CALCIUM REGULATORY PROTEINS IN RAT MYOCARDIAL CELL. | 2017 | Afr J Tradit Complement Altern Med | pmid:28638869 |
| Suswillo RF et al. | Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. | 2017 | Cell Biochem. Funct. | pmid:28083967 |
| Chen J et al. | Glycyrrhetinic acid alleviates radiation-induced lung injury in mice. | 2017 | J. Radiat. Res. | pmid:27672101 |
| Du H et al. | Insight into the role of dual-ligand modification in low molecular weight heparin based nanocarrier for targeted delivery of doxorubicin. | 2017 | Int J Pharm | pmid:28359815 |
| Ji B et al. | Development and validation of a sensitive and fast UPLC-MS/MS method for simultaneous determination of seven bioactive compounds in rat plasma after oral administration of Guizhi-gancao decoction. | 2017 | J Pharm Biomed Anal | pmid:28088663 |
| Wang J et al. | Pharmacokinetics study of Erhuang decoction extracts in rats by HPLC-MS/MS. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28570935 |
| Yan G et al. | Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25287740 |
| Oyama K et al. | Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus. | 2016 | PLoS ONE | pmid:27820854 |
| Wojciechowski K et al. | Complexation of phospholipids and cholesterol by triterpenic saponins in bulk and in monolayers. | 2016 | Biochim. Biophys. Acta | pmid:26654784 |
| Zhu Y et al. | Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. | 2016 | Cell Metab. | pmid:27626200 |
| Queiroga CS et al. | Paracrine effect of carbon monoxide - astrocytes promote neuroprotection through purinergic signaling in mice. | 2016 | J. Cell. Sci. | pmid:27383770 |
| Huang YC et al. | 18α-Glycyrrhetinic Acid Induces Apoptosis of HL-60 Human Leukemia Cells through Caspases- and Mitochondria-Dependent Signaling Pathways. | 2016 | Molecules | pmid:27376261 |
| Ikarashi Y and Mizoguchi K | Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. | 2016 | Pharmacol. Ther. | pmid:27373856 |
| Jeon YD et al. | Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo. | 2016 | Molecules | pmid:27110761 |
| Yu J et al. | Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal. | 2016 | Endocrinology | pmid:27035651 |
| Cao D et al. | The Protective Effects of 18β-Glycyrrhetinic Acid on Helicobacter pylori-Infected Gastric Mucosa in Mongolian Gerbils. | 2016 | Biomed Res Int | pmid:27006947 |
| Li SN et al. | Effect of Connexin43 on Mechanical Tension-stimulated Osteogenic Transcription Factors of Human Periodontal Ligament Fibroblasts. | 2016 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:26956851 |
| Cong Y et al. | One-step Conjugation of Glycyrrhetinic Acid to Cationic Polymers for High-performance Gene Delivery to Cultured Liver Cell. | 2016 | Sci Rep | pmid:26902258 |
| Papaevgeniou N et al. | 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures. | 2016 | Antioxid. Redox Signal. | pmid:26886723 |
| Li Y et al. | Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives. | 2016 | Molecules | pmid:26861280 |
| Yamada A et al. | Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation. | 2016 | J. Biol. Chem. | pmid:26565022 |
| Takeuchi R et al. | Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth. | 2016 | Br. J. Pharmacol. | pmid:26676684 |
| Chen F et al. | Glycyrrhetinic acid-decorated and reduction-sensitive micelles to enhance the bioavailability and anti-hepatocellular carcinoma efficacy of tanshinone IIA. | 2016 | Biomater Sci | pmid:26484363 |
| Yan T et al. | Effective co-delivery of doxorubicin and curcumin using a glycyrrhetinic acid-modified chitosan-cystamine-poly(ε-caprolactone) copolymer micelle for combination cancer chemotherapy. | 2016 | Colloids Surf B Biointerfaces | pmid:27281238 |
| Wang FZ et al. | Codelivery of Doxorubicin and shAkt1 by Poly(ethylenimine)-Glycyrrhetinic Acid Nanoparticles To Induce Autophagy-Mediated Liver Cancer Combination Therapy. | 2016 | Mol. Pharm. | pmid:26894988 |
| Saito Z et al. | Effectiveness of hepatoprotective drugs for anti-tuberculosis drug-induced hepatotoxicity: a retrospective analysis. | 2016 | BMC Infect. Dis. | pmid:27835982 |
| Huang QC et al. | Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? | 2016 | Oncotarget | pmid:26498361 |
| Gong H et al. | A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. | 2015 | J Ethnopharmacol | pmid:25557030 |
| Yang H et al. | The protection of glycyrrhetinic acid (GA) towards acetaminophen (APAP)-induced toxicity partially through fatty acids metabolic pathway. | 2015 | Afr Health Sci | pmid:26957996 |
| Chen Q et al. | Preparation and characterization of glycyrrhetinic acid-modified stearic acid-grafted chitosan micelles. | 2015 | Artif Cells Nanomed Biotechnol | pmid:24093764 |
| Li J et al. | Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid. | 2015 | Int J Nanomedicine | pmid:26346750 |
| Zhou J et al. | 18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination. | 2015 | Sci Rep | pmid:26329786 |
| Zhang H et al. | Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor. | 2015 | Acta Pharmacol. Sin. | pmid:26279158 |
| Kitagawa H et al. | Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study. | 2015 | PLoS ONE | pmid:26151135 |
| Wu HJ et al. | Glycyrrhetinic Acid protects the heart from ischemia/reperfusion injury by attenuating the susceptibility and incidence of fatal ventricular arrhythmia during the reperfusion period in the rat hearts. | 2015 | Cell. Physiol. Biochem. | pmid:26021262 |
| Chang J et al. | Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways. | 2015 | PLoS ONE | pmid:26011146 |
| Qu Y et al. | Effects of 18α-glycyrrhizin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis. | 2015 | Int J Clin Exp Pathol | pmid:25973013 |
| Chen J et al. | A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation. | 2015 | Drug Des Devel Ther | pmid:25945038 |
| Schrobback K et al. | The importance of connexin hemichannels during chondroprogenitor cell differentiation in hydrogel versus microtissue culture models. | 2015 | Tissue Eng Part A | pmid:25693425 |
| Gupta P et al. | Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation. | 2015 | Antimicrob. Agents Chemother. | pmid:25691644 |
| Sigurjónsdóttir Hà and Wallerstedt S | [Licorice--so much more than candy]. | 2015 | Lakartidningen | pmid:25689012 |
| Zhu J et al. | Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathway. | 2015 | Int. J. Oncol. | pmid:25573651 |
| Mirza MU et al. | Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson's disease: a pharmacoinformatics study. | 2015 | Drug Des Devel Ther | pmid:25565772 |
| Zhou B et al. | The influence of compatibility of processed radix Aconiti Kusnezoffii on the pharmacokinetic of four components in Glycyrrhiza uralensis Fisch. | 2015 | J Ethnopharmacol | pmid:25889555 |
| Link P et al. | Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-β toxicity in Caenorhabditis elegans. | 2015 | Planta Med. | pmid:25782036 |
| Qi WW et al. | Doxorubicin-loaded glycyrrhetinic acid modified recombinant human serum albumin nanoparticles for targeting liver tumor chemotherapy. | 2015 | Mol. Pharm. | pmid:25584860 |
| Bhatia C et al. | Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. | 2015 | Chem. Biol. Interact. | pmid:25526675 |
| Sakamoto S et al. | Effect of glycyrrhetinic acid on lipid raft model at the air/water interface. | 2015 | Biochim. Biophys. Acta | pmid:25445675 |